Japanese Journal of Ophthalmology

, Volume 51, Issue 4, pp 270–277 | Cite as

Role of Photodynamic Therapy in Polypoidal Choroidal Vasculopathy

  • Eriko Akaza
  • Mitsuko Yuzawa
  • Yoko Matsumoto
  • Shiho Kashiwakura
  • Kyoko Fujita
  • Ryusaburo Mori
CLINICAL INVESTIGATION

Abstract

Purpose

To determine the efficacy of photodynamic therapy (PDT) with verteporfin for polypoidal choroidal vasculopathy (PCV).

Methods

PDT was performed in 35 patients (35 eyes) with PCV. We evaluated the number of treatments and compared visual acuity (VA), ophthalmological findings, and changes in polypoidal lesions and branching vascular networks by measuring lesion diameters using Heidelberg retina angiography before PDT, and then every 3 months for 1 year after PDT.

Results

The mean annual number of treatment sessions was 2.2. VA was improved or maintained in 80% of the patients. Retinal pigment epithelium detachment, retinal detachment, hemorrhage, and/or exudates disappeared in 69%, and leakage resolved in 74% of the patients. Polypoidal lesions disappeared completely on indocyanine green angiography in 83% of the patients. All branching vascular networks persisted. Polypoidal lesions had recurred at the termini of the remaining branching vascular networks at 9 months after the first PDT in two eyes and at 12 months in one eye.

Conclusions

PDT with verteporfin for PCV appears to improve or maintain VA for the first posttreatment year. Approximately 70% of PCV cases showed improved ophthalmoscopic findings. However, as polypoidal lesions recur after PDT in some cases, further study is needed to confirm the long-term efficacy of PDT for PCV. Jpn J Ophthalmol 2007;51:270–277 @ Japanese Ophthalmological Society 2007

Key words

photodynamic therapy polypoidal choroidal vasculopathy recurrence of polypoidal lesion remaining branching vascular networks verteporfin 

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Copyright information

© Japanese Ophthalmological Society 2007

Authors and Affiliations

  • Eriko Akaza
    • 1
  • Mitsuko Yuzawa
    • 1
  • Yoko Matsumoto
    • 1
  • Shiho Kashiwakura
    • 1
  • Kyoko Fujita
    • 1
  • Ryusaburo Mori
    • 1
  1. 1.Department of OphthalmologySurugadai Hospital of Nihon UniversityTokyoJapan
  2. 2.Department of OphthalmologySurugadai Hospital of Nihon UniversityTokyoJapan

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