Japanese Journal of Ophthalmology

, Volume 51, Issue 1, pp 10–13 | Cite as

Efficacy of α-Lipoic Acid Against Diabetic Cataract in Rat

  • Masami Kojima
  • Li Sun
  • Ikuho Hata
  • Yasuo Sakamoto
  • Hiroshi Sasaki
  • Kazuyuki Sasaki



α-Lipoic acid (LA) is well known as a powerful antioxidant. The efficacy of dihydrolipoate-LA for oral administration against streptozotocin (STZ)-induced diabetic cataract in rat was investigated.


Rats were divided into three groups, control, diabetes mellitus (DM), and DM treated with LA (DM+LA). Diabetes was induced by intravenous injection of 50 mg/kg STZ. DM+LA rats were fed 30 mg/rat per day LA in their diet. Lens changes were assessed using Scheimpflug images (EAS-1000) and by measuring light-scattering intensity.


Increase in lens light scattering was less (P < 0.05) in DM+LA rats than in DM rats 5 weeks after induction of diabetes. DM rats had the highest and control rats the lowest blood glucose levels at every measurement point up to 111 days (P < 0.05).


LA treatment delayed development and progression of cataract in rats with streptozotocin-induced diabetes. Jpn J Ophthalmol 2007;51:10–13 © Japanese Ophthalmological Society 2007

Key words

antioxidant diabetic cataract α-lipoic acid lipoic acid rat 


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Copyright information

© Japanese Ophthalmological Society 2007

Authors and Affiliations

  • Masami Kojima
    • 1
    • 2
  • Li Sun
    • 2
  • Ikuho Hata
    • 2
  • Yasuo Sakamoto
    • 1
    • 2
  • Hiroshi Sasaki
    • 1
    • 2
  • Kazuyuki Sasaki
    • 2
  1. 1.Department of OphthalmologyKanazawa Medical UniversityIshikawaJapan
  2. 2.Division of Vision Research for Environmental Health, Medical Research InstituteKanazawa Medical UniversityIshikawaJapan

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