Topical Atropine in Retarding Myopic Progression and Axial Length Growth in Children with Moderate to Severe Myopia: A Pilot Study
- 542 Downloads
To study the safety and efficacy of topical 1% atropine eye ointment in retarding myopic progression in children with moderate to severe myopia.
This was an interventional control study. Children (aged 5–10 years) with myopia of −3.00 diopters (D) or more were treated with 1% atropine ointment once daily for 1 year. Baseline and regular assessments of refractive errors by cycloplegic autorefraction and of axial length were done by ultrasound biometry, and the results were compared with data of control subjects.
Twenty-three children (mean age: 7.4 ± 1.6 years) with moderate to severe myopia, being treated in the Hong Kong Eye Hospital of the Chinese University of Hong Kong, were recruited into the atropine group, and 23 children from the same eye clinic were matched with the study subjects with respect to age, sex, and initial spherical equivalent refraction, as controls. The initial refractive errors were −5.18 ± 2.05 D and −5.12 ± 2.33 D in the atropine and the control groups, respectively (P = 0.934). Myopic progression was significantly less (P = 0.005) in the atropine group (+0.06 ± 0.79 D) than in the control group (−1.19 ± 2.48 D). Axial length increase was also significantly smaller in the atropine group (0.09 ± 0.19 mm) than in the control group (0.70 ± 0.63 mm) (P = 0.004). One child (4.3%) developed an allergic reaction. No other major adverse effects related to the treatment were noted.
Topical 1% atropine ointment is a safe and effective treatment for retarding myopic progression in moderate to severe myopia. Further large-scale randomised controlled study with longer follow-up seems warranted. Jpn J Ophthalmol 2007;51:27–33 © Japanese Ophthalmological Society 2007
Key wordsatropine myopia myopic progression
Unable to display preview. Download preview PDF.
- 14.Chew, SJ, Saw, SM, Rajan, U 1998Rigid gas-permeable contact lenses in the control of myopia progressionTokoro, T eds. Myopia updates: proceedings of the 6th international conference on myopiaSpringer-VerlagTokyoGoogle Scholar
- 22.Kao, SC, Lu, HY, Liu, JH 1988Atropine effect on school myopia. A preliminary reportActa Ophthalmol185132133Google Scholar
- 38.Taylor, BJ, Smith, PJ, Brook, CG 1985Inhibition of physiological growth hormone secretion by atropineClin Endocrinol22497501Google Scholar
- 39.Casanueva, FF, Villanueva, L, Diaz, Y, Devesa, J, Fernandez-Cruz, A, Schally, AV 1986Atropine selectively blocks GHRH-induced GH secretion without altering LH, FSH, TSH, PRL and ACTH/cortisol secretion elicited by their specific hypothalamic releasing factorsClin Endocrinol25319323Google Scholar
- 43.Jensen, H 1991Myopia progression in young school children. A prospective study of myopia progression and the effect of a trial with bifocal lenses and beta blocker eye dropsActa Ophthalmol200179Google Scholar