Japanese Journal of Ophthalmology

, Volume 50, Issue 4, pp 312–317 | Cite as

Correlation Between Higher Blood Flow Velocity in the Central Retinal Vein than in the Central Retinal Artery and Severity of Nonproliferative Diabetic Retinopathy

  • Sayuri Fujioka
  • Kaoruko Karashima
  • Norikiyo Nishikawa
  • Yoshihiro Saito



To assess the correlation between a higher blood flow velocity in the central retinal vein (CRV) than in the central retinal artery (CRA) and the severity of nonproliferative diabetic retinopathy (non-PDR).


We evaluated both eyes of 20 non-PDR patients with higher peak systolic velocity (PSV) in the CRV than in the CRA unilaterally as determined by color Doppler imaging (CDI). The eyes with higher PSV in the CRV were placed in group D2-H, and the fellow eyes were placed in group D2-L. The stage of non-PDR was determined by the guidelines of the Early Treatment Diabetic Retinopathy Study. Normal subjects and non-PDR patients without higher PSV in the CRV were evaluated as CDI controls.


Advanced non-PDR (P = 0.001) and cystoid macular edema (P = 0.02) were statistically more frequent in group D2-H. The velocities in the ophthalmic artery and the short posterior ciliary artery were not statistically different among all groups. The velocities in the CRA were similar in all non-PDR groups and significantly lower than in the normal subjects (P < 0.05). The velocities in the CRV were significantly higher only in group D2-H (P < 0.001).


Higher PSV in the CRV than in the CRA was significantly correlated with the severity of non-PDR, especially in the presence of cystoid macular edema. Jpn J Ophthalmol 2006;50:312–317 © Japanese Ophthalmological Society 2006

Key words

color Doppler imaging cystoid macular edema Early Treatment Diabetic Retinopathy Study higher blood flow velocity nonproliferative diabetic retinopathy 


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  1. 1.
    Guven, D, Ozdemir, H, Hasanreisoglu, B 1996Hemodynamic alterations in diabetic retinopathyOphthalmology10312451249PubMedGoogle Scholar
  2. 2.
    Goebel, W, Lieb, WE, Ho, A,  et al. 1995Color Doppler imaging: a new technique to assess orbital blood flow in patients with diabetic retinopathyInvest Ophthalmol Vis Sci36864870PubMedGoogle Scholar
  3. 3.
    Fujioka, S, Karashima, K, Nishikawa, N, Saito, Y 2004Optic disk manifestation in diabetic eyes with low serum albumin: late fluorescein staining and high blood flow velocities in the optic diskJpn J Ophthalmol485964PubMedCrossRefGoogle Scholar
  4. 4.
    Miller, NR 1982

    Anatomy and physiology of the optic nerve

    Miller, NRNewman, NJBiousse, VKerrison, JBWalsh, FBHoyt, WF eds. Walsh and Hoyt's clinical neuro-ophthalmology4th edWilliams & WilkinsBaltimore4159
    Google Scholar
  5. 5.
    Early Treatment Diabetic Retinopathy Study Research Group1991Grading diabetic retinopathy from stereoscopic color fundus photographs: an extension of the modified Airlie House classification, ETDRS report number 10Ophthalmology98786806Google Scholar
  6. 6.
    Early Treatment Diabetic Retinopathy Study Research Group1991Fundus photographic risk factors for progression of diabetic retinopathy. ETDRS report number 12Ophthalmology98823833Google Scholar
  7. 7.
    Lieb, WE, Cohen, SM, Merton, DA,  et al. 1991Color Doppler imaging of the eye and orbitArch Ophthalmol109527531PubMedGoogle Scholar
  8. 8.
    Williamson, TH, Harris, A 1996Color Doppler ultrasound imaging of the eye and orbitSurv Ophthalmol40255267PubMedCrossRefGoogle Scholar
  9. 9.
    Frank, RN 1994

    Etiologic mechanisms in diabetic retinopathy

    Schachat, APMurphy, RB eds. Retina2nd edMosbySt. Louis12431276
    Google Scholar
  10. 10.
    Tsujikawa, A, Otani, A, Takanashi, T, Ogura, Y 1995Long term prognosis of extracapsular cataract extraction and intraocular lens implantation in diabetic patientsJpn J Ophthalmol41319323CrossRefGoogle Scholar
  11. 11.
    Mendivil, A 1997Ocular blood flow velocities in patients with proliferative diabetic retinopathy after panretinal photocoagulationSurv Ophthalmol428995Google Scholar
  12. 12.
    Mendivil, A, Cuartero, V, Mendivil, MP 1995Ocular blood flow velocities in patients with proliferative diabetic retinopathy and healthy volunteers: a prospective studyBr J Ophthalmol79413416PubMedGoogle Scholar
  13. 13.
    Fujioka, S 2003Use of orbital color Doppler imaging for detecting internal carotid artery stenosis in patients with amaurosis fugaxJpn J Ophthalmol47276280PubMedCrossRefGoogle Scholar
  14. 14.
    Fujioka, S, Karashima, K, Nishikawa, N 2002Ocular findings and color Doppler images in diabetic patients with reverse ophthalmic artery and internal carotid artery stenosis/occlusionNihon Ganka Kiyo (Folia Ophthalmol Jpn)53860864Google Scholar
  15. 15.
    Dimitrova, G, Kato, S, Yamashita, Y,  et al. 2003Relation between retrobulbar circulation and progression of diabetic retinopathyBr J Ophthalmol87622625PubMedCrossRefGoogle Scholar

Copyright information

© Japanese Ophthalmological Society 2006

Authors and Affiliations

  • Sayuri Fujioka
    • 1
  • Kaoruko Karashima
    • 1
  • Norikiyo Nishikawa
    • 2
  • Yoshihiro Saito
    • 3
  1. 1.Department of OphthalmologyOsaka Medical Center for Cancer and Cardiovascular DiseasesOsakaJapan
  2. 2.Department of OphthalmologyOsaka Police HospitalOsakaJapan
  3. 3.Department of OphthalmologyOsaka National HospitalOsakaJapan

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