Japanese Journal of Ophthalmology

, Volume 50, Issue 5, pp 474–478 | Cite as

An Asian Patient with Intraocular Lymphoma Treated by Intravitreal Methotrexate

  • Jia-Kang Wang
  • Chung-May Yang
  • Chang-Ping LinEmail author
  • Yin-Dong Shan
  • Andy Y. Lo
  • Hwei-Fang Tien



To demonstrate the efficacy of intravitreal methotrexate for treating intraocular lymphoma.


A 55-year-old immunocompetent Asian man was diagnosed with intraocular lymphoma.


The patient was initially managed by intravenous administration of high-dose methotrexate. Because vitreous cells persisted after systemic chemotherapy, methotrexate was given intravitreally thereafter. There was only self-limited corneal epitheliopathy without major complications following intraocular injections. Ocular remission was sustained during a 21-month follow-up.


Intravitreal methotrexate is an effective, repeatable, and safe treatment for intraocular lymphoma. Jpn J Ophthalmol 2006;50:474–478 © Japanese Ophthalmological Society 2006

Key words

chemotherapy intraocular lymphoma intravitreal injection methotrexate primary central nervous system lymphoma 


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Copyright information

© Japanese Ophthalmological Society 2006

Authors and Affiliations

  • Jia-Kang Wang
    • 1
  • Chung-May Yang
    • 2
  • Chang-Ping Lin
    • 2
    Email author
  • Yin-Dong Shan
    • 2
  • Andy Y. Lo
    • 1
  • Hwei-Fang Tien
    • 3
  1. 1.Department of OphthalmologyFar Eastern Memorial HospitalTaipeiTaiwan
  2. 2.Department of OphthalmologyNational Taiwan University HospitalTaipeiTaiwan
  3. 3.Department of Internal MedicineNational Taiwan University HospitalTaipeiTaiwan

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