Human Herpesvirus-8 in Kaposi's Sarcoma of the Conjunctiva in a Patient with AIDS
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To demonstrate human herpesvirus-8 (HHV-8) in Kaposi's sarcoma (KS) of the conjunctiva in a patient with acquired immunodeficiency syndrome (AIDS).
Clinical observation, pathologic findings of conjunctival specimens, immunohistochemical staining for HHV-8-specific antigen, polymerase chain reaction (PCR) analysis of HHV-8 DNA, and detection of specific antibody in patient's serum at appropriate times.
In the conjunctival specimen, swollen endothelial-like cells were found with slit-like vessels. CD 31-positive cells were noted on the inner surface of the slit-like vessels, and HHV-8 latency-associated nuclear antigen was detected. The presence of HHV-8 DNA was demonstrated by PCR. Anti-HHV-8 antibody was found in the patient's serum.
This is the first case report in the ophthalmology literature that provides histological, DNA, and serological evidence that HHV-8 is involved in the pathogenesis of conjunctival KS. Jpn J Ophthalmol 2006;50:7–11 © Japanese Ophthalmological Society 2006
Key wordsAIDS conjunctiva human herpesvirus-8 Kaposi's sarcoma latency-associated nuclear antigen
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- 2.Havercos, HW, Drotman, DP 1985Prevalence of Kaposi's sarcoma among patients with AIDSN Engl J Med3121518Google Scholar
- 3.Jabs, DA, Quinn, TC 1996
Acquired immunodeficiency syndromePepose, JSHolland, GNWilhelmus, KR eds. Ocular Infection and ImmunityMosbySt. Louis289310Google Scholar