Advertisement

Japanese Journal of Ophthalmology

, Volume 48, Issue 6, pp 570–572 | Cite as

Excimer Laser Photokeratectomy Reactivates Latent Herpes Simplex Virus

  • Tatsunori DeaiEmail author
  • Masahiko Fukuda
  • Yumiko Tomoda
  • Shiro Higaki
  • Kozaburo Hayashi
  • Yoshikazu Shimomura
CLINICAL INVESTIGATION

Abstract

Background

It has been reported that excimer laser irradiation might elicit herpes simplex virus (HSV) genome activation. We describe a clinical case in which HSV DNA sequences were detected quantitatively after phototherapeutic keratectomy (PTK).

Case

A 90-year-old woman underwent excimer laser photokeratectomy for bilateral band-shaped keratopathy. Tear film was collected from both eyes using a Schirmer’s strip before and 3 and 7 days after phototherapeutic keratectomy.

Observations

HSV-DNA was quantified by a real-time polymerase chain reaction assay. HSV-DNA was detected only on the third day postoperatively in both eyes. The amount of viral DNA was 2.0 × 105 (OD) and 1.3 × 105 (OS) copies/sample, respectively.

Conclusions

Excimer laser photokeratectomy stimulated viral shedding in the tear film. Ophthalmologists should be aware that laser irradiation can reactivate latent HSV. Jpn J Ophthalmol 2004;48:570–572 © Japanese Ophthalmological Society 2004

Key words

excimer laser herpes simplex virus real-time polymerase chain reaction assay viral shedding 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Japanese Ophthalmological Society 2004

Authors and Affiliations

  • Tatsunori Deai
    • 1
    Email author
  • Masahiko Fukuda
    • 1
  • Yumiko Tomoda
    • 1
  • Shiro Higaki
    • 1
  • Kozaburo Hayashi
    • 2
  • Yoshikazu Shimomura
    • 1
  1. 1.Department of OphthalmologyKinki University School of MedicineOsaka-SayamaJapan
  2. 2.National Eye InstituteBethesdaUSA

Personalised recommendations