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Japanese Journal of Ophthalmology

, Volume 48, Issue 5, pp 448–453 | Cite as

Implantation of a Keratoprosthesis of Novel Design in Rabbits

  • Koji Sugioka
  • Masahiko FukudaEmail author
  • Tsuyoshi Hibino
  • Motonari Watanabe
  • Ichiro Ando
  • Yoshikazu Shimomura
Laboratory Investigation

Abstract

Purpose

To evaluate a keratoprosthesis, implanted by penetrating keratoplasty, in rabbits.

Methods

We implanted our keratoprosthesis (optics and flange portions of polymethylmethacrylate and a polyurethane skirt with micropores) into 14 eyes of 14 rabbits. In four eyes, we evaluated histologically the junction between the keratoprosthesis and host cornea. Long-term keratoprosthesis survival was evaluated in ten eyes by slit-lamp biomicroscopy.

Results

The histological study showed good approximation of the keratoprosthesis to the host cornea in the junction area, with overlying superficial corneal stroma on the skirt, keratocyte and collagen fiber ingrowth into the micropores, and partial migration of epithelial cells onto the skirt. However, in the long-term survival study, eight out of ten eyes developed acute suture-related inflammation, considered to be from bacterial infection, requiring enucleation 30 ± 18 weeks after implantation. The remaining two eyes have survived for 70 and 76 weeks.

Conclusions

Our keratoprosthesis was well tolerated in the short term. However, further modifications are necessary to avoid corneal infection.

Key Words

biointegration corneal prosthesis keratoprosthesis polymethylmethacrylate ocular implant rabbit keratoplasty model 

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Copyright information

© Japanese Ophthalmological Society 2004

Authors and Affiliations

  • Koji Sugioka
    • 1
  • Masahiko Fukuda
    • 1
    Email author
  • Tsuyoshi Hibino
    • 1
  • Motonari Watanabe
    • 2
  • Ichiro Ando
    • 2
  • Yoshikazu Shimomura
    • 1
  1. 1.Department of OphthalmologyKinki University School of MedicineOsakaJapan
  2. 2.Menicon Company, Ltd.AichiJapan

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