Wiener Medizinische Wochenschrift

, Volume 162, Issue 23–24, pp 519–524

Food allergy prevalence: new possibilities for therapy and prevention

main topic
  • 442 Downloads

Summary

Food allergy is an important clinical problem of increasing prevalence worldwide. Immunoglobulin E (IgE)-mediated allergic responses are the most widely recognized form of food allergy. The prevalence of food allergy is influenced by country, age, culture, and dietary habits. Strategies for the prevention of food allergy have been extensively studied. There is currently no standard treatment for food allergy and allergen-specific immunotherapy has been hindered by severe side effects in the past. A mutated recombinant major apple allergen is clinically hypoallergenic, which paves the way toward safer immunotherapy for the treatment of food-allergic patients.

Traditional Chinese medicine (TCM) is one of the oldest medical practices in the world. A Chinese Food Allergy Herbal Formula-2 (FAHF-2) has been used as a therapy for food allergy patients. FAHF-2 was shown to be remarkably effective against food anaphylaxis in an animal model and in human clinical trial with the potential to be a long-lasting therapy.

Keywords

Food allergy Prevalence Complementary and alternative medicine Traditional Chinese medicine 

Prävalenz von Nahrungsmittelallergien – Neue Möglichkeiten für Therapie und Prävention

Zusammenfassung

Nahrungsmittelallergien sind ein wichtiges klinisches Problem mit weltweit zunehmender Verbreitung. IgE-vermittelte allergische Reaktionen sind die am meisten anerkannte Form der Nahrungsmittelallergie. Die Häufigkeit von Nahrungsmittelallergien wird von Land, Alter, Kultur und Ernährungsgewohnheiten beeinflusst. Strategien zur Prävention von Nahrungsmittelallergien wurden ausgiebig untersucht. Derzeit gibt es keine anerkannte Standardbehandlung für Nahrungsmittelallergien, und Allergen-spezifische Immuntherapien wurden in der Vergangenheit oft von schweren Nebenwirkungen begleitet. Ein mutiertes rekombinantes Apfel-Hauptallergen erwies sich klinisch als hypoallergen und öffnet damit die Tür zu einer sichereren Immuntherapie für die Behandlung von Nahrungsmittelallergien.

Die Traditionelle Chinesische Medizin (TCM) ist eine der ältesten medizinischen Praktiken in der Welt. Eine chinesische Kräuterrezeptur (Food Allergy Herbal Formula-2, FAHF-2) wurde zur Therapie von Patienten mit Nahrungsmittelallergie getestet. FAHF-2 erwies sich sowohl im Tiermodell als auch in einer humanen klinischen Studie als bemerkenswert effektiv gegen Nahrungsmittelallergie und hat das Potenzial als dauerhafte Therapie eingesetzt werden zu können.

Schlüsselwörter

Nahrungsmittelallergie Prävalenz Komplementäre und alternative Medizin Traditionelle Chinesische Medizin 

References

  1. 1.
    Katz Y. Food allergy epidemic: can we reverse the trend? Isr Med Assoc J. 2012;14(1):5–6, 3.PubMedGoogle Scholar
  2. 2.
    Han Y, Kim J, Ahn K. Food allergy. Korean J Pediatr. 2012;55(5):153–8.PubMedCrossRefGoogle Scholar
  3. 3.
    Dreborg S. Food allergy in pollen-sensitive patients. Ann Allergy. 1988;61:41–6.PubMedGoogle Scholar
  4. 4.
    Wood RA. The natural history of food allergy. Pediatrics. 2003;111(6 Pt 3):1631–7.PubMedGoogle Scholar
  5. 5.
    Hourihane JO, Roberts SA, Warner JO. Resolution of peanut allergy: casecontrol study. BMJ. 1998;316:1271–5.PubMedCrossRefGoogle Scholar
  6. 6.
    MacDougall CF, Cast AJ, Colver AF. How dangerous is food allergy in childhood? The incidence of severe and fatal allergic reactions across the UK and Ireland. Arch Dis Child. 2002;86:236–9.PubMedCrossRefGoogle Scholar
  7. 7.
    Connors L, Waserman S. Food allergy—the nuts and bolts. Parkhurst Exchange. 2010;18. http://www.parkhurstexchange.com/clinicalreviews/apr10/food-allergy. Accessed 14 Oct. 2010.Google Scholar
  8. 8.
    The Food Allergy & Anaphylaxis Network. http://www.foodallergy.org. 2010. Accessed 14 Sept. 2010.Google Scholar
  9. 9.
    Sampson HA. Food allergy. Part 1: immunopathogenesis and clinical disorders. J Allergy Clin Immunol. 1999;103(5 Pt 1):717–28.PubMedCrossRefGoogle Scholar
  10. 10.
    Waserman S, Watson W. Food allergy. Allergy Asthma Clin Immunol. 2011;7(Suppl 1):S7.PubMedCrossRefGoogle Scholar
  11. 11.
    Sampson HA. Update on food allergy. J Allergy Clin Immunol. 2004;113:805–19.PubMedCrossRefGoogle Scholar
  12. 12.
    Sicherer SH, Sampson HA. Food allergy. J Allergy Clin Immunol. 2006;117(2, Suppl Mini-Primer):S470–5.PubMedCrossRefGoogle Scholar
  13. 13.
    Sicherer SH, Sampson HA. Food allergy. J Allergy Clin Immunol. 2010;125(2, Suppl 2):S116–25.PubMedCrossRefGoogle Scholar
  14. 14.
    Sicherer SH. Food allergy. Lancet. 2002;360:701–10.PubMedCrossRefGoogle Scholar
  15. 15.
    Sicherer SH, Muñoz-Furlong A, Murphy R, Wood RA, Sampson HA. Symposium: pediatric food allergy. Pediatrics. 2003;111:1591–4.Google Scholar
  16. 16.
    Eigenmann PA, Sicherer SH, Borkowski TA, Cohen BA, Sampson HA. Prevalence of IgE-mediated food allergy among children with atopic dermatitis. Pediatrics. 1998;101(3):e8.PubMedCrossRefGoogle Scholar
  17. 17.
    Sampson HA. Food allergy. J Allergy Clin Immunol. 2003;111(Suppl 2):S540–7.PubMedCrossRefGoogle Scholar
  18. 18.
    Beyer K, Morrow E, Li XM, Bardina L, Bannon GA, Burks AW, et al. Effects of cooking methods on peanut allergenicity. J Allergy Clin Immunol. 2001;107:1077–81.PubMedCrossRefGoogle Scholar
  19. 19.
    Fernández-Rivas M, Bolhaar S, González-Mancebo E, Asero R, van Leeuwen A, Bohle B, Ma Y, Ebner C, Rigby N, Sancho AI, Miles S, Zuidmeer L, Knulst A, Breiteneder H, Mills C, Hoffmann-Sommergruber K, van Ree R. Apple allergy across Europe: how allergen sensitization profiles determine the clinical expression of allergies to plant foods. J Allergy Clin Immunol. 2006 ;118(2):481–8.PubMedCrossRefGoogle Scholar
  20. 20.
    Connors L, Waserman S. Food allergy—the nuts and bolts. Parkhurst Exchange. 2010;18. http://www.parkhurstexchange.com/clinicalreviews/apr10/food-allergy. Accessed 14 Oct. 2010.Google Scholar
  21. 21.
    Sampson HA, Munoz-Furlong A, Scurlock AM, Lee LA, Burks AW. Food allergy in children. Immunol Allergy Clin N Am. 2005;25:369–88.CrossRefGoogle Scholar
  22. 22.
    Scurlock AM, Lee LA, Burks AW. Food allergy in children. Immunol Allergy Clin N Am. 2005;25:369–88.CrossRefGoogle Scholar
  23. 23.
    Canadian Society of Allergy and Clinical Immunology. Anaphylaxis in schools and other settings. 2nd ed. CSACI; 2009.Google Scholar
  24. 24.
    Bolhaar ST, Zuidmeer L, Ma Y, Ferreira F, Bruijnzeel-Koomen CA, Hoffmann-Sommergruber K, van Ree R, Knulst AC. A mutant of the major apple allergen, Mal d 1, demonstrating hypo-allergenicity in the target organ by double-blind placebo-controlled food challenge. Clin Exp Allergy. 2005;35(12):1638–44.PubMedCrossRefGoogle Scholar
  25. 25.
    Ma Y, Gadermaier G, Bohle B, Bolhaar S, Knulst A, Markovic-Housley Z, Breiteneder H, Briza P, Hoffmann-Sommergruber K, Ferreira F. Mutational analysis of amino acid positions crucial for IgE-binding epitopes of the major apple (Malus domestica) allergen, Mal d 1. Int Arch Allergy Immunol. 2006;139(1):53–62.PubMedCrossRefGoogle Scholar
  26. 26.
    Burks A. Peanut allergy. Lancet. 2008;371:1538–46.PubMedCrossRefGoogle Scholar
  27. 27.
    Katz Y, Rajuan N, Goldberg MR, et al. Early exposure to cow’s milk protein is protective against IgE-mediated cow’s milk protein allergy. J Allergy Clin Immunol. 2010;126:77–82, 5.PubMedCrossRefGoogle Scholar
  28. 28.
    Du Toit G, Katz Y, Sasieni P, et al. Early consumption of peanuts in infancy is associated with a low prevalence of peanut allergy. J Allergy Clin Immunol. 2008;122:978–85, 25.Google Scholar
  29. 29.
    Koppelmann SJ, Bruijnzeel-koomen CAFM, Hessing M, de Jongh HHJ. Heat-induced conformational changes of Ara H 1, a major peanut allergen, do not affect its allergenic properties. J Biol Chem. 1999;274:4770–7.CrossRefGoogle Scholar
  30. 30.
    Ballmer-Weber BK. Pollenassoziierte Nahrungsmittelallergien. Ernährung. 2008;2:10–15. doi:10.1007/s12082-007-0119-y.CrossRefGoogle Scholar
  31. 31.
    Nowak-Wegrzyn A, Assa’ad AH, Bahna SL, Bock SA, Sicherer SH, Teuber SS. Adverse reactions to Food Committee of American Academy of Allergy, Asthma & Immunology: work group report: oral food challenge testing. J Allergy Clin Immunol. 2009;123:S365–83.PubMedCrossRefGoogle Scholar
  32. 32.
    Ballmer-Weber BK, Hoffmann A, Wüthrich B. Influence of food processing on the allergenicity of celery: DBPCFC with celery spice and cooked celery in patients with celery allergy. Allergy. 2002;57:228–35.PubMedCrossRefGoogle Scholar
  33. 33.
    Hansen KS, Ballmer-Weber BK, Luttkopf D. Roasted hazelnuts—allergenic activity evaluated by double-blind, placebo-controlled food challenge. Allergy. 2003;58:132–8.PubMedCrossRefGoogle Scholar
  34. 34.
    Vargas PA, Sicherer SH, Christie L, Keaveny M, Noone S, Watkins D. Developing a food allergy curriculum for parents. Pediatr Allergy Immunol. 2011;22:575–82.PubMedCrossRefGoogle Scholar
  35. 35.
    Li XM. Treatment of asthma and food allergy with herbal interventions from traditional Chinese medicine. Mt Sinai J Med. 2011;78:697–716.PubMedCrossRefGoogle Scholar
  36. 36.
    Li XM. Traditional Chinese herbal remedies for asthma and food allergy. J Allergy Clin Immunol. 2007 ;120(1):25–31. doi:10.1016/j.jaci.2007.04.030.PubMedCrossRefGoogle Scholar
  37. 37.
    Li XM, Zhang TF, Sampson H, Zou ZM, Beyer K, Wen MC, Schofield B. The potential use of Chinese herbal medicines in treating allergic asthma. Ann Allergy Asthma Immunol. 2004;93:S35–44.PubMedCrossRefGoogle Scholar
  38. 38.
    Li XM, Huang CK, Zhang TF, Teper AA, Srivastava K, Schofield BH, Sampson HA. The Chinese herbal medicine formula MSSM-002 suppresses allergic airway hyperreactivity and modulates TH1/TH2 responses in a murine model of allergic asthma. J Allergy Clin Immunol. 2000;106:660–8.PubMedCrossRefGoogle Scholar
  39. 39.
    Chan K, Shaw D, Simmonds MS, Leon CJ, Xu Q, Lu A, Sutherland I, Ignatova S, Zhu YP, Verpoorte R, Williamson EM, Duez P. Good practice in reviewing and publishing studies on herbal medicine, with special emphasis on traditional Chinese medicine and Chinese materia medica. J Ethnopharmacol. 2012;140:469–75.PubMedCrossRefGoogle Scholar
  40. 40.
    Tejedor Garcia N, et al. MEDLINE-based assessment of animal studies on Chinese herbal medicine. J Ethnopharmacol. 2012;140(3):545–9.PubMedCrossRefGoogle Scholar
  41. 41.
    Uzuner H, Fan TP, Dias A, Guo DA, El-Nezami HS. Establishing an EU-China consortium on traditional Chinese medicine research. Chin Med. 2010;5:42.PubMedCrossRefGoogle Scholar
  42. 42.
    Novak N, Haberstok J, Kraft S, Siekmann L, Allam JP, Bieber T. Standardized extracts from Chinese herbs induce IL-10 production in human monocyte-derived dendritic cells and alter their differentiation in vitro. J Allergy Clin Immunol. 2001 ;108(4):588–93.PubMedCrossRefGoogle Scholar
  43. 43.
    Wang J, Li XM. Chinese herbal therapy for the treatment of food allergy. Curr Allergy Asthma Rep. 2012 ;12(4):332–8.PubMedCrossRefGoogle Scholar
  44. 44.
    Li XM. Complementary and alternative medicine in pediatric allergic disorders. Curr Opin Allergy Clin Immunol. 2009;9(2):161–7.PubMedCrossRefGoogle Scholar
  45. 45.
    Jindal V, Ge A, Mansky PJ. Safety and efficacy of acupuncture in children: a review of the evidence. J Pediatr Hematol Oncol. 2008;30:431–42.PubMedCrossRefGoogle Scholar
  46. 46.
    Hon KL, Leung TF, Ng PC, et al. Efficacy and tolerability of a Chinese herbal medicine concoction for treatment of atopic dermatitis: a randomized, doubleblind, placebo-controlled study. Br J Dermatol. 2007;157:357–63.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Wien 2012

Authors and Affiliations

  1. 1.Department of Pathophysiology and Allergy ResearchVienna General Hospital, Medical University ViennaViennaAustria

Personalised recommendations