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Calcium handling and atrial fibrillation

Kalzium-Handling und Vorhofflimmern

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Summary

Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia in the clinical setting. It is associated with substantial cardiovascular morbidity and mortality. Recent research has indicated that abnormal Ca2+ handling plays a critical role in the induction and maintenance of AF, contributing to ectopic activity, AF-maintaining reentry circuits and related prothrombotic atrial hypocontractility. The AF-specific Ca2+-handling abnormalities may constitute viable therapeutic approaches to treat AF. Here, we review the causes, consequences, and therapeutic implications of altered atrial Ca2+ handling for AF pathophysiology.

Zusammenfassung

Vorhofflimmern („atrial fibrillation“, AF) ist die häufigste Herzrhythmusstörung in der klinischen Praxis und ist assoziiert mit einer deutlich erhöhten kardiovaskulären Morbidität und Mortalität. Neuere Studien haben gezeigt, dass Störungen der intrazellulären Kalzium-Homöostase („Kalzium-Handling“) eine entscheidende Rolle bei der Entstehung und Aufrechterhaltung von AF spielen. Gestörtes Kalzium-Handling kann zu ektoper Aktivität, zur Ausbildung von kreisenden Erregungen („Reentry“) und zur atrialen Hypokontraktilität beitragen. Die Aufklärung vorhofspezifischer Veränderungen des Kalzium-Handlings bei AF könnte zur Entwicklung neuer therapeutischer Optionen für die Behandlung des AF führen. Diese Übersichtsarbeit fasst Ursachen und Folgen des veränderten Kalzium-Handlings bei AF zusammen und zeigt darauf beruhende neue therapeutische Ansatzpunkte auf.

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Conflict of interest

The authors declare that there is no actual or potential conflict of interest in relation to this article.

Author information

Correspondence to Univ.-Prof. Dr. med. Dobromir Dobrev MD.

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Heijman, J., Voigt, N., Nattel, S. et al. Calcium handling and atrial fibrillation. Wien Med Wochenschr 162, 287–291 (2012) doi:10.1007/s10354-012-0109-9

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Keywords

  • Atrial fibrillation
  • Atrial remodeling
  • Calcium handling
  • Ectopic activity

Schlüsselwörter

  • Vorhofflimmern
  • Atriales Remodeling
  • Kalzium-Handling
  • Ektope Aktivität