Sex and gender differences in myocardial hypertrophy and heart failure

Vera Regitz-Zagrosek; Ute Seeland

doi:10.1007/s10354-011-0892-8

Wiener Medizinische Wochenschrift

March 2011, Volume 161, Issue 5–6, pp 109–116

Sex and gender differences in myocardial hypertrophy and heart failure

Authors
Authors and affiliations

Vera Regitz-ZagrosekEmail author
Ute Seeland

Main topic

Received:: 12 October 2010
Accepted:: 22 February 2011

Summary

Cardiovascular disease is the most common cause of death in men and women worldwide. Men develop most, but not all, cardiovascular diseases at an earlier age while the number of affected women significantly increases with higher age. Heart failure (HF) is a common cause of cardiovascular death and carries a poor prognosis in both genders. Risk factors and myocardial adaptations in HF in men and women are different. Female hearts develop a more favorable physiological form of myocardial remodeling than male hearts. This may be related to sex hormones, estrogens and testosterone. A clinical study for gender differences in human aortic stenosis supports the hypotheses. HF management differs between both sexes, with underdiagnosis and undertreatment and less use of invasive therapies in women. Nevertheless, women frequently have better outcomes than men. Gender research will contribute directly to patient-oriented benefit by suggesting clinical protocols.

Keywords

Aortic stenosis Dilated cardiomyopathy Estradiol Extracellular matrix Heart failure

Abbreviations:

AR: androgen receptor
AS: aortic stenosis
AVR: aortic valve replacement
DCM: dilated cardiomyopathy
E2: estradiol
ECM: extracellular matrix
ER: estrogen receptor
HF: heart failure
LVH: left ventricular hypertrophy
MH: myocardial hypertrophy
MMP: matrix metalloproteinases

Geschlechterunterschiede in Myokardhypertrophie und Herzinsuffizienz

Zusammenfassung

Kardiovaskuläre Erkrankungen sind die häufigste Todesursache bei Männern und Frauen. Männer entwickeln kardiovaskuläre Erkrankungen häufiger in einem jüngeren, Frauen in einem späten Alter. Herzinsuffizienz (HF) führt zu einer signifikanten Verschlechterung der Lebenserwartung und ist für beide Geschlechter ungünstig. Risikofaktoren und myokardiale Anpassungsreaktionen bei HF unterscheiden sich bei Männern und Frauen. Frauen entwickeln mehr physiologische Hypertrophie, während Männer eher exzentrische Hypertrophie und Dilatation entwickeln. Das mag mit Sexualhormonen, Östrogenen und Androgenen zusammen hängen. Eine klinische Studie zu Geschlechterunterschieden bei menschlicher Aortenstenose unterstützt unsere Hypothese. Die Behandlung der Herzinsuffizienz unterscheidet sich bei beiden Geschlechtern, Frauen werden weniger intensiv behandelt. Allerdings haben sie dennoch meistens einen günstigeren Verlauf. Genderspezifische Medizin wird direkt zu einer Verbesserung des Managements bei Frauen und Männern beitragen.

Schlüsselwörter

Aortenstenose Dilatative Kardiomyopathie Estradiol Extrazelluläre Matrix Herzinsuffizienz

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Authors and Affiliations

Vera Regitz-Zagrosek
- 1
- 3
Email author
Ute Seeland
- 2

1.Institute of Gender in Medicine (GiM) and Center for Cardiovascular Research (CCR)Charité University MedicineBerlinGermany
2.Center for Gender in Medicine (GiM)Charité University MedicineBerlinGermany
3.German Heart Institute (DHZB)BerlinGermany

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Sex and gender differences in myocardial hypertrophy and heart failure

Summary

Keywords

Abbreviations:

Geschlechterunterschiede in Myokardhypertrophie und Herzinsuffizienz

Zusammenfassung

Schlüsselwörter

Preview

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