Wiener Medizinische Wochenschrift

, Volume 160, Issue 11–12, pp 276–280

Komplikationen durch Diuretikatherapie bei geriatrischen Patienten

  • Ronald Otto
  • Regina E. Roller
  • Bernhard Iglseder
  • Peter Dovjak
  • Monika Lechleitner
  • Ulrike Sommeregger
  • Ursula Benvenuti-Falger
  • Birgit Böhmdorfer
  • Markus Gosch
Themenschwerpunkt
  • 159 Downloads

Zusammenfassung

Diuretika sind für die Anwendung bei geriatrischen Patienten in Hinblick auf ihre Wirksamkeit evaluiert. Die Wirkstoffe dieser Gruppen werden jedoch oft ohne Rücksichtnahme auf den Zustand und funktionelle Einschränkungen des Patienten verordnet. In vielen Fällen verstärken sich bekannte unerwünschte Nebenwirkungen durch Zusammenwirken mehrerer Wirkstoffe. Polypragmasie ist ein bedeutender Risikofaktor für Adverse-drug-reactions (ADR). Diese ADRs treten bei alten Patienten besonders häufig im Zusammenhang mit dem Einsatz von Diuretika auf. Ursächlich scheint neben dem Umbau des Körpers im Alter auch eine unkontrollierte Therapieführung zu sein. Die vorliegende Arbeit versucht unter Verwendung von Literatur aus PubMed die potentielle Gefahr einer Therapie mit diuretischen Wirkstoffen bei geriatrischen Patienten und die daraus resultierende klinische Relevanz darzustellen.

Schlüsselwörter

Diuretika Ältere Unerwünschte Arzneimittelwirkung Polypharmazie 

Diuretics-related complications in elderly patients

Summary

Diuretics are well studied and evaluated for their beneficial use in geriatric patients. However those drugs are often used without taking care of subjects condition or functional impairment. Known side effects of those substances may be increased by combinations of multiple drugs. Polypharmacy is a strong risk factor for the incidence of adverse drug reactions (ADR). ADRs are frequently found in combination with the use of diuretics. The remodelling of human body in aging process and uncontrolled therapeutic strategies seem to be causal for that finding. This article tries to work out the potential risk of the usage of those drugs in geriatric patients and its clinical relevance by using literature published in PubMed.

Keywords

Diuretics Elderly Adverse drug events Polypharmacy 

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Ronald Otto
    • 1
  • Regina E. Roller
    • 1
  • Bernhard Iglseder
    • 2
  • Peter Dovjak
    • 3
  • Monika Lechleitner
    • 4
  • Ulrike Sommeregger
    • 5
  • Ursula Benvenuti-Falger
    • 4
  • Birgit Böhmdorfer
    • 6
  • Markus Gosch
    • 4
  1. 1.Universitätsklinik für Innere MedizinMedizinische Universität GrazGrazAustria
  2. 2.Universitätsklinik für GeriatrieParacelsus Medizinische PrivatuniversitätSalzburgAustria
  3. 3.Abteilung für Akutgeriatrie/RemobilisationLandeskrankenhaus GmundenGmundenAustria
  4. 4.Abteilung für Innere Medizin und AkutgeriatrieLandeskrankenhaus HochzirlZirlAustria
  5. 5.Abteilung für AkutgeriatrieKrankenhaus Hietzing mit Neurologischem Zentrum RosenhügelWienAustria
  6. 6.AnstaltsapothekeKrankenhaus Hietzing mit Neurologischem Zentrum RosenhügelWienAustria

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