Wiener Medizinische Wochenschrift

, Volume 159, Issue 1–2, pp 17–23 | Cite as

Vareniclin – medikamentöse Therapie der Tabakabhängigkeit

  • Patricia Tschabitscher
  • Irmgard Homaier
  • Alfred Lichtenschopf
  • Ernest Groman
Themenschwerpunkt

Zusammenfassung

Jedes Jahr gibt es in Europa 1,2 Millionen Todesfälle, die auf Zigarettenkonsum zurückzuführen sind. Effektive Raucherentwöhnung ist daher von besonderer Bedeutung. Vareniclin ist das erste Medikament, das speziell zur Raucherentwöhnung neu entwickelt wurde. Die Wirksamkeit von Vareniclin bei der Raucherentwöhnung beruht auf seiner Wirkung als partieller Agonist/Antagonist am α4β2-Nikotinrezeptor. Dieser duale Wirkmechanismus bewirkt einerseits eine Verminderung des Rauchverlangens sowie eine Linderung der Entzugssymptome und hemmt andererseits die direkte Wirkung des Rauchens. Dieser Artikel diskutiert die derzeitigen Studiendaten zur Sicherheit und Effektivität von Vareniclin und dessen Bedeutung in der Raucherentwöhnung.

Schlüsselwörter

Vareniclin Raucherentwöhnung Nikotinabgängigkeit 

Varenicline – pharmacological therapy of tobacco dependence

Summary

Every year about 1.2 million deaths attributable to smoking occur in Europe. Effective smoking cessation, therefore, is essential. Varenicline is the first medication specifically developed for smoking cessation. The efficacy of varenicline in smoking cessation is due to its role as a partial agonist/antagonist at the α4β2 nicotine receptors. This dual action causes a reduction in cigarette craving as well as withdrawal symptoms; moreover, it decreases the pleasurable and reinforcing effects of smoking. This article discusses the current clinical data regarding efficacy and safety of varenicline and its role in smoking cessation.

Key words

Varenicline Smoking cessation Nicotine dependence 

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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Patricia Tschabitscher
    • 1
  • Irmgard Homaier
    • 2
  • Alfred Lichtenschopf
    • 3
  • Ernest Groman
    • 4
  1. 1.Pfizer Corporation AustriaWienAustria
  2. 2.Pulmogisches Zentrum WienBaumgartner HöheWienAustria
  3. 3.Sonderkrankenanstalten SKA-RZ WeyerWeyerAustria
  4. 4.Institut für Sozialmedizin, Zentrum für Public HealthMedizinische Universität Wien und Nikotin InstitutWienAustria

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