Journal of Pest Science

, Volume 86, Issue 2, pp 353–360

Synthesis of N-substituted dimethylmaleimides and their antifungal activities against Sclerotinia sclerotiorum

  • Zhenzhong Shen
  • Yongxian Fan
  • Fuge Li
  • Xiaolong Chen
  • Yinchu Shen
Original paper

DOI: 10.1007/s10340-012-0466-6

Cite this article as:
Shen, Z., Fan, Y., Li, F. et al. J Pest Sci (2013) 86: 353. doi:10.1007/s10340-012-0466-6

Abstract

Compounds with maleimide, both natural and synthesized, have good biological activities, especially the antifungal activity. In order to investigate the antifungal activity of dimethylmaleimides, 17 N-substituted dimethylmaleimides were prepared from the reactions of 2,3-dimethyl maleic anhydride and amines using a facile synthetic method in this paper. These compounds were evaluated for antifungal activities against Sclerotinia sclerotiorum by the mycelium growth rate method. They exhibited minimum inhibitory concentrations (MICs) ranging from 0.01–50.0 μg/mL, with N-(2-benzimidazole)-3,4-dimethylmaleimide being the most active one with an MIC of 0.01 μg/mL. The structure and activity relationship on these compounds indicated that the hydrophobicity of the N-substituents is associated with their antifungal activity. Compared to current antifungals, most of N-substituted dimethylmaleimides have a perfect activity for S. sclerotiorum control and low toxicity.

Keywords

Dimethylmaleimides Sclerotinia sclerotiorum Antifungal activity Fungicide 

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Zhenzhong Shen
    • 1
  • Yongxian Fan
    • 1
  • Fuge Li
    • 1
  • Xiaolong Chen
    • 1
  • Yinchu Shen
    • 1
  1. 1.Institute of Fermentation Engineering, College of Biological and Environmental EngineeringZhejiang University of TechnologyHangzhouPeople’s Republic of China

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