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Cognitive Processing

, 10:55 | Cite as

Multimodal encoding in a simplified model of intracellular calcium signaling

  • Maurizio De Pittà
  • Vladislav Volman
  • Herbert Levine
  • Eshel Ben-JacobEmail author
Research Report

Abstract

Many cells use calcium signaling to carry information from the extracellular side of the plasma membrane to targets in their interior. Since virtually all cells employ a network of biochemical reactions for Ca2+ signaling, much effort has been devoted to understand the functional role of Ca2+ responses and to decipher how their complex dynamics is regulated by the biochemical network of Ca2+-related signal transduction pathways. Experimental observations show that Ca2+ signals in response to external stimuli encode information via frequency modulation (FM) or alternatively via amplitude modulation (AM). Although minimal models can capture separately both types of dynamics, they fail to exhibit different and more advanced encoding modes. By arguments of bifurcation theory, we propose instead that under some biophysical conditions more complex modes of information encoding can also be manifested by minimal models. We consider the minimal model of Li and Rinzel and show that information encoding can occur by AM of Ca2+ oscillations, by FM or by both modes (AFM). Our work is motivated by calcium signaling in astrocytes, the predominant type of cortical glial cells that is nowadays recognized to play a crucial role in the regulation of neuronal activity and information processing of the brain. We explain that our results can be crucial for a better understanding of synaptic information transfer. Furthermore, our results might also be important for better insight on other examples of physiological processes regulated by Ca2+ signaling.

Keywords

Calcium Information encoding Astrocyte Bifurcation Li-Rinzel 

Notes

Acknowledgments

The authors thank V. Parpura, G. Carmignoto, B. Ermentrout, B. Sautois and N. Raichman for insightful conversations on Ca2+ dynamics and its capability of encoding information. V. Volman acknowledges the support of U.S. National Science Foundation I2CAM International Materials Institute Award, grant DMR-0645461. This research has been supported by the Tauber Fund at Tel Aviv University, by the Maguy-Glass Chair in Physics of Complex Systems, and by he NSF-sponsored Center for Theoretical Biological Physics (grant nos. PHY-0216576 and PHY-0225630).

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Copyright information

© Marta Olivetti Belardinelli and Springer-Verlag 2008

Authors and Affiliations

  • Maurizio De Pittà
    • 1
  • Vladislav Volman
    • 2
    • 3
  • Herbert Levine
    • 2
  • Eshel Ben-Jacob
    • 1
    • 2
    Email author
  1. 1.School of Physics and AstronomyTel Aviv UniversityRamat AvivIsrael
  2. 2.Center for Theoretical Biological PhysicsLa JollaUSA
  3. 3.Computational Neurobiology LabThe Salk InstituteLa JollaUSA

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