Cognitive Processing

, Volume 7, Issue 2, pp 89–94

The supplementary motor area in motor and perceptual time processing: fMRI studies

Research Report


The neural bases of timing mechanisms in the second-to-minute range are currently investigated using multidisciplinary approaches. This paper documents the involvement of the supplementary motor area (SMA) in the encoding of target durations by reporting convergent fMRI data from motor and perceptual timing tasks. Event-related fMRI was used in two temporal procedures, involving (1) the production of an accurate interval as compared to an accurate force, and (2) a dual-task of time and colour discrimination with parametric manipulation of the level of attention attributed to each parameter. The first study revealed greater activation of the SMA proper in skilful control of time compared to force. The second showed that increasing attentional allocation to time increased activity in a cortico-striatal network including the pre-SMA (in contrast with the occipital cortex for increasing attention to colour). Further, the SMA proper was sensitive to the attentional modulation cued prior to the time processing period. Taken together, these data and related literature suggest that the SMA plays a key role in time processing as part of the striato-cortical pathway previously identified by animal studies, human neuropsychology and neuroimaging.


Motor and perceptual timing Supplementary motor area (SMA) Event-related fIRM 


  1. Ackermann H, Gräber S, Hertrich I, Daum I (1999) Cerebellar contributions to the perception of temporal cues within the speech and nonspeech domain. Brain Lang 67:228–241PubMedCrossRefGoogle Scholar
  2. Basso G, Nichelli P, Wharton CM, Peterson M, Grafman J (2003) Distributed neural systems for temporal production: a functional MRI study. Brain Res Bull 59(5):405–411PubMedCrossRefGoogle Scholar
  3. Brown SW (1997) Attentional resources in timing: interference effects in concurrent temporal and nontemporal working memory tasks. Percept Psychoph 59:1118–1140Google Scholar
  4. Brunia CHM, de Jong BM, van den Berg-Lenssen MMC, Paans AMJ (2000) Visual feedback about time estimation is related to a right hemisphere activation measured by PET. Exp Brain Res 130:328–337PubMedCrossRefGoogle Scholar
  5. Casini L, Macar F (1997) Effects of attention manipulation on perceived duration and intensity in the visual modality. Mem Cogn 2:912–818Google Scholar
  6. Cesara A, Hagberg GE, Bianciardi M, Sabatini U (2005) Visually cued motor synchronization: modulation of fMRI activation patterns by baseline condition. Neurosci Lett 373:323–337Google Scholar
  7. Coull J (2004) fMRI studies of temporal attention: allocating attention within, or towards, time. Cogn Brain Res 21:216–226CrossRefGoogle Scholar
  8. Coull JT, Vidal F, Nazarian B, Macar F (2004) Functional anatomy of the attentional modulation of time estimation. Science 303(5663):1506–1508PubMedCrossRefGoogle Scholar
  9. Dettmers C, Fink GR, Lemon RN, Stephan KM, Passingham RE, Silbersweig D, Holmes A, Ridding MC, Brooks DJ, Frackowiak RSJ (1995) Relation between cerebral activity and force in the motor areas of the human brain. J Neurophysiol 74:802–815PubMedGoogle Scholar
  10. Elsinger CL, Rao SM, Zimbelman JL, Reynolds NC, Blindauer KA, Hoffmann RG (2003) Neural basis for impaired time reproduction in Parkinson’s disease: an fMRI study. J Int Neuropsy Soc 9:1088–1098Google Scholar
  11. Friston KJ, Holmes AP, Worsley KJ, Poline JB, Frith CD, Frackowiak RSJ (1995) Statistical parametric maps in functional imaging: a general linear approach. Hum Brain Map 2:189CrossRefGoogle Scholar
  12. Friston KJ, Fletcher PC, Josephs O, Holmes AP, Rugg MD, Turner R (1998) Event-related fMRI: characterizing differential responses. NeuroImage 7:30PubMedCrossRefGoogle Scholar
  13. Gibbon J, Malapani C, Dale CL, Gallistel CR (1997) Toward a neurobiology of temporal cognition: advances and challenges. Curr Opin Neurobiol 7:170–184PubMedCrossRefGoogle Scholar
  14. Hadjikhani N, Liu AK, Dale AM, Cavanagh P, Tootell RBH (1998) Retinotopy and color sensitivity in human visual cortical area V8. Nat Neurosci 1:235–241PubMedCrossRefGoogle Scholar
  15. Halsband U, Ito N, Tanji J, Freund HJ (1993) The role of premotor cortex and the supplementary motor area in the temporal control of movement in man. Brain 116:243–246PubMedCrossRefGoogle Scholar
  16. Harrington DL, Haaland KY (1999) Neural underpinnings of temporal processing: a review of focal lesion, pharmacological, and functional imaging research. Rev Neurosci 10:91–116PubMedGoogle Scholar
  17. Harrington DL, Boyd LA, Mayer AR, Sheltraw DM, Lee RR, Huang M, Rao SM (2004) Neural representation of interval encoding and decision making. Cogn Brain Res 21:193–205CrossRefGoogle Scholar
  18. Hinton SC, Meck WH (2004) Fronto-striatal circuitry activated by human peak-interval timing in the supra-seconds range. Cogn Brain Res 21:171–182CrossRefGoogle Scholar
  19. Hinton SC, Harrington DL, Binder JR, Durgerian S, Rao SM (2004) Neural systems supporting timing and chronometric counting: an fMRI study. Cogn Brain Res 21:183–192CrossRefGoogle Scholar
  20. Ivry RB, Spencer RMC (2004) The neural representation of time. Curr Opin Neurobiol 14:225–232PubMedCrossRefGoogle Scholar
  21. Jäncke L, Shah NJ, Peters M (2000) Cortical activations in primary and secondary motor areas for complex bimanual movements in professional pianists. Cogn Brain Res 10:177–183CrossRefGoogle Scholar
  22. Jantzen KJ, Steinberg FL, Kelso JAS (2002) Practice-dependent modulation of neural activity during human sensorimotor coordination: a functional magnetic resonance imaging study. Neurosci Lett 332:205–209PubMedCrossRefGoogle Scholar
  23. Josephs O, Turner R, Friston KJ (1997) Event-related fMRI. Hum Brain Mapping 5:243CrossRefGoogle Scholar
  24. Kawashima R, Okuda J, Umetsu A, Sugiura M, Inoue K, Suzuki K, Tabuchi M, Tsukiura T, Narayan SL, Nagasaka T, Yanagawa I, Fujii T, Takahashi S, Fukuda H, Yamadori A (2000) Human cerebellum plays an important role in memory-timed finger movement: an fMRI study. J Neurophysiol 83:1079–1087PubMedGoogle Scholar
  25. Kudo K, Miyazaki M, Kimura T, Yamanaka K, Kadota H, Hirashima M, Nakajima Y, Nakazawa K, Ohtsuki T (2004) Selective activation and deactivation of the human brain structures between speeded and precisely timed tapping responses to identical visual stimulus: an fMRI study. NeuroImage 22:1291–1301PubMedCrossRefGoogle Scholar
  26. Kuhtz-Buschbeck JP, Ehrsson HH, Forssberg H (2001) Human brain activity in the control of fine static precision grip forces: an fMRI study. Eur J Neurosci 14:382–390PubMedCrossRefGoogle Scholar
  27. Lang W, Obrig H, Lindinger G, Cheyne D, Deecke L (1990) Supplementary motor area activation while tapping bimanually different rhythms in musicians. Exp Brain Res 79:504–514PubMedCrossRefGoogle Scholar
  28. Lewis PA, Miall RC (2003a) Distinct systems for automatic and cognitively controlled time measurement: evidence from neuroimaging. Curr Opin Neurobiol 13:1–6CrossRefGoogle Scholar
  29. Lewis PA, Miall RC (2003b) Brain activation patterns during measurement of sub-and supra-second intervals. Neuropsychologia 41:1583–1592CrossRefGoogle Scholar
  30. Lewis PA, Wing AM, Pope PA, Praamstra P, Miall RC (2004) Brain activity correlates differentially with increasing temporal complexity of rhythms during initialisation, synchronization, and continuation phases of paced finger tapping. Neuropsychologia 42:1301–1312PubMedCrossRefGoogle Scholar
  31. Macar F, Vidal F (2004) Event-related potentials as indices of time processing: a review. J Psychophysiol 18(2–3):89–104CrossRefGoogle Scholar
  32. Macar F, Grondin S, Casini L (1994) Controlled attention sharing influences time estimation. Mem Cogn 22(6):673–686Google Scholar
  33. Macar F, Lejeune H, Bonnet M, Ferrara A, Pouthas V, Vidal F, Maquet P (2002) Activation of the supplementary motor area and of attentional networks during temporal processing. Exp Brain Res 142:539–550CrossRefGoogle Scholar
  34. Macar F, Anton J-L, Bonnet M, Vidal F (2004) Timing functions of the supplementary motor area: an event-related fMRI study. Cogn Brain Res 21(2):206–215CrossRefGoogle Scholar
  35. Mathiak K, Hertrich I, Grodd W, Ackermann H (2004) Discrimination of temporal information at the cerebellum: functional magnetic resonance imaging of nonverbal auditory memory. NeuroImage 21:154–162PubMedCrossRefGoogle Scholar
  36. Mayville JM, Jantzen KJ, Fuchs A, Steinberg FL, Kelso JAS (2002) Cortical and subcortical networks underlying syncopated and synchronized coordination revealed using fMRI. Hum Brain Mapping 17(4):214–229CrossRefGoogle Scholar
  37. Meck WM (1996) Neuropharmacology of timing and time perception. Cogn Brain Res 3:227–242CrossRefGoogle Scholar
  38. Picard N, Strick PL (1996) Motor areas of the medial wall: a review of their location and functional activation. Cerebr Cortex 6:342–353CrossRefGoogle Scholar
  39. Rao SM, Harrington DL, Haaland KY, Bobholz JA, Cox RW, Binder JR (1997) Distributed neural systems underlying the timing of movements. J Neurosci 17:5528–5535PubMedGoogle Scholar
  40. Rao SM, Mayer AR, Harrington DL (2001) The evolution of brain activation during temporal processing. Nat Neurosci 4:317–323PubMedCrossRefGoogle Scholar
  41. Rubia K, Overmeyer S, Taylor E, Brammer M, Williams S, Simmons A, Andrew C, Bullmore E (1998) Prefrontal involvement in “temporal bridging” and timing movement. Neuropsychologia 36:1283–1293PubMedCrossRefGoogle Scholar
  42. Sergent J, Zuck E, Terriah S, MacDonald B (1992) Distributed neural network underlying musical sight-reading and keyboard performance. Science 257:106–109PubMedCrossRefGoogle Scholar
  43. Smith A, Taylor E, Lidzba K, Rubia K (2003) A right hemispheric frontocerebellar network for time discrimination of several hundreds of milliseconds. NeuroImage 20:344–350PubMedCrossRefGoogle Scholar
  44. Tanji J (1994) The supplementary motor area in the cerebral cortex. Neurosci Res 19:251–268PubMedCrossRefGoogle Scholar
  45. Thomas EAC, Weaver WB (1975) Cognitive processing and time perception. Percept Psychoph 17:363–367Google Scholar
  46. Zakay D (1989) Subjective time and attentional resource allocation. An integrated model of time estimation. In: Levin I, Zakay D (eds) Time and human cognition: a life span perspective. North Holland, Amsterdam, pp 365–397Google Scholar
  47. Zeki S, Watson JD, Lueck CJ, Friston KJ, Kennard C, Frackowiak RS (1991) A direct demonstration of functional specialization in human visual cortex. J Neurosci 11:641–649PubMedGoogle Scholar

Copyright information

© Marta Olivetti Belardinelli and Springer-Verlag 2006

Authors and Affiliations

  • Françoise Macar
    • 1
  • Jennifer Coull
    • 1
  • Franck Vidal
    • 2
  1. 1.Françoise Macar - LNCCNRS-Université de Provence, Centre St-Charles, Case C.Marseille cedex 3France
  2. 2.IMNSSAToulonFrance

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