The History of the Core–Shell Particles and Applications in Active Pharmaceutical Ingredients Via Liquid Chromatography

  • Mehmet Gumustas
  • Przemyslaw Zalewski
  • Sibel A. Ozkan
  • Bengi Uslu
Part of the following topical collections:
  1. 50th Anniversary Commemorative Issue


High performance liquid chromatography (HPLC) and ultrahigh performance liquid chromatography (UHPLC or UPLC) have been the most widely used tools for research and routine quality control of active pharmaceutical ingredients (API). The most important challenge in these techniques is fast and efficient separation. Both techniques are preferred due to their selectivity, high accuracy and remarkable precision. On the other hand, they have some limitations: In some cases, traditional HPLC uses high amounts of organic solvents with longer analysis time, and furthermore UHPLC has high back pressure and frictional heating. To overcome these limitations, scientists have developed new type of column particles. In general, two different silica types of column packing material based on their backbone have been used for HPLC and UHPLC. Stationary phases that have fully porous silica particles comply with the essential criteria of analysis, but these show all the limitations of HPLC. However, in recent years, core–shell silica particles (a combination of solid core and porous shell) have been increasingly used for highly efficient separation with reduced run times. Thus, core–shell technology provides the same efficient separations as the sub 2 µm particles that are used in UHPLC, while eliminating the disadvantages (potentially lower backpressure). The key factors for core–shell particles are size and thickness of porous shell layer, the latter of which can be explained using the Van Deemter equation. The columns packed with core–shell particles have been employed in a wide range of applications for analysis and quality control of pharmaceutical active substances. This review will underline the advantages of core–shell silica particles in the analysis of pharmaceutically active ingredients based on liquid chromatography from the perspective of column properties, system suitability test parameter results and validation steps.


HPLC UHPLC UPLC Core–shell Pharmaceutical Validation 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


  1. 1.
    Snyder LR, Dolan JW (2017) Chap. 1—milestones in the development of liquid chromatography. In: Liquid chromatography (Second Edition), Fanali S, Haddad PR, Poole CF, Riekkola M-L (eds) Elsevier, Oxford, pp. 1–15Google Scholar
  2. 2.
    Horvath CG, Preiss BA, Lipsky SR (1967) Anal Chem 39:1422–1428. CrossRefPubMedGoogle Scholar
  3. 3.
    Horvath C, Lipsky SR (1969) J Chromatogr Sci 7:109–116. CrossRefGoogle Scholar
  4. 4.
    Kirkland JJ (1969) Anal Chem 41:218–220. CrossRefGoogle Scholar
  5. 5.
    Kirkland JJ, Truszkowski FA, Dilks CH Jr, Engel GS (2000) J Chromatogr A 890:3–13CrossRefGoogle Scholar
  6. 6.
    Gritti F, Cavazzini A, Marchetti N, Guiochon G (2007) J Chromatogr A 1157:289–303. CrossRefPubMedGoogle Scholar
  7. 7.
    Fekete S, Fekete J, Ganzler K (2009) J Pharm Biomed Anal 49:64–71. CrossRefPubMedGoogle Scholar
  8. 8.
    Gritti F, Guiochon G (2011) J Chromatogr A 1218:3476–3488. CrossRefPubMedGoogle Scholar
  9. 9.
    Gritti F, Guiochon G (2011) Chem Eng Sci 66:3773–3781. CrossRefGoogle Scholar
  10. 10.
    Gritti F, Guiochon G (2011) J Chromatogr A 1218:907–921. CrossRefPubMedGoogle Scholar
  11. 11.
    Omamogho JO, Hanrahan JP, Tobin J, Glennon JD (2011) J Chromatogr A 1218:1942–1953. CrossRefPubMedGoogle Scholar
  12. 12.
    Kirkland JJ, Truszkowski FA, Dilks CH, Engel GS (2000) J Chromatogr A 890:3–13. CrossRefPubMedGoogle Scholar
  13. 13.
    Kirkland JJ (1992) Anal Chem 64:1239–1245. CrossRefGoogle Scholar
  14. 14.
    Honda F, Honda H, Koishi M (1992) J Chromatogr A 609:49–59. CrossRefGoogle Scholar
  15. 15.
    Gritti F, Farkas T, Heng J, Guiochon G (2011) J Chromatogr A 1218:8209–8221. CrossRefPubMedGoogle Scholar
  16. 16.
    Destefano JJ, Langlois TJ, Kirkland JJ (2008) J Chromatogr Sci 46:254–260CrossRefGoogle Scholar
  17. 17.
    Deng T-S, Marlow F (2012) Chem Mater 24:536–542. CrossRefGoogle Scholar
  18. 18.
    Büchel G, Unger Klaus K, Matsumoto A, Tsutsumi K (1999) Adv Mater 10:1036–1038.;2-Z CrossRefGoogle Scholar
  19. 19.
    Deng Y, Qi D, Deng C, Zhang X, Zhao D (2008) J Am Chem Soc 130:28–29. CrossRefPubMedGoogle Scholar
  20. 20.
    Han L, Wei H, Tu B, Zhao D (2011) Chem Commun 47:8536–8538. CrossRefGoogle Scholar
  21. 21.
    Kim JH, Jeon TY, Choi TM, Shim TS, Kim S-H, Yang S-M (2014) Langmuir 30:1473–1488. CrossRefPubMedGoogle Scholar
  22. 22.
    Nie Z, Park JI, Li W, Bon SAF, Kumacheva E (2008) J Am Chem Soc 130:16508–16509. CrossRefPubMedGoogle Scholar
  23. 23.
    Lan W, Li S, Xu J, Luo G (2011) Langmuir 27:13242–13247. CrossRefPubMedGoogle Scholar
  24. 24.
    Kaczmarski K, Guiochon G (2007) Anal Chem 79:4648–4656. CrossRefPubMedGoogle Scholar
  25. 25.
    Marchetti N, Guiochon G (2007) J Chromatogr A 1176:206–216. CrossRefPubMedGoogle Scholar
  26. 26.
    Ali I, Al-kindy SMZ, Suliman FO, Alam SD (2011) Anal Methods 3:2836–2841. CrossRefGoogle Scholar
  27. 27.
    Alpert AJ (1990) J Chromatogr A 499:177–196. CrossRefGoogle Scholar
  28. 28.
    McCalley DV (2008) J Chromatogr A 1193:85–91. CrossRefPubMedGoogle Scholar
  29. 29.
    Grumbach ES, Wagrowski-Diehl DM, Mazzeo JR, Alden B, Iraneta PC (2004) LC GC N Am 22:1010–1023Google Scholar
  30. 30.
    Ali I, Al-Othman ZA, Nagae N, Gaitonde VD, Dutta KK (2012) J Sep Sci 35:3235–3249. CrossRefPubMedGoogle Scholar
  31. 31.
    Ali I, Al-Othman ZA, Al-Za’abi M (2012) Biomed Chromatogr: BMC 26:1001–1008. CrossRefPubMedGoogle Scholar
  32. 32.
    Fekete S, Oláh E, Fekete J (2012) J Chromatogr A 1228:57–71. CrossRefPubMedGoogle Scholar
  33. 33.
    Gritti F (2011) Am Pharm Rev 14:26–33Google Scholar
  34. 34.
    Torquato S (1985) J Appl Phys 58:3790–3797. CrossRefGoogle Scholar
  35. 35.
    Hayes R, Ahmed A, Edge T, Zhang H (2014) J Chromatogr A 1357:36–52. CrossRefPubMedGoogle Scholar
  36. 36.
    van Deemter JJ, Zuiderweg FJ, Klinkenberg A (1956) Chem Eng Sci 5:271–289. CrossRefGoogle Scholar
  37. 37.
    van Deemter JJ, Zuiderweg FJ, Klinkenberg A (1995) Chem Eng Sci 50:3869–3882. CrossRefGoogle Scholar
  38. 38.
    Knox JH (1999) J Chromatogr A 831:3–15. CrossRefGoogle Scholar
  39. 39.
    Knox JH, Scott HP (1983) J Chromatogr A 282:297–313. CrossRefGoogle Scholar
  40. 40.
    Schuster SA, Boyes BE, Wagner BM, Kirkland JJ (2012) Journal of chromatography A 1228:232–241. CrossRefPubMedGoogle Scholar
  41. 41.
    Ettre LS, Sakodynskii KI (1993) Chromatographia 35:223–231. CrossRefGoogle Scholar
  42. 42.
    Gritti F, Guiochon G (2012) J Chromatogr A 1228:2–19. CrossRefPubMedGoogle Scholar
  43. 43.
    Gritti F, Guiochon G (2012) LCGC N Am 30Google Scholar
  44. 44.
    Gritti F, Tanaka N, Guiochon G (2012) J Chromatogr A 1236:28–41. CrossRefPubMedGoogle Scholar
  45. 45.
    Guiochon G, Gritti F (2011) J Chromatogr A 1218:1915–1938. CrossRefPubMedGoogle Scholar
  46. 46.
    Kirkland JJ, Schuster SA, Johnson WL, Boyes BE (2013) J Pharm Anal 3:303–312. CrossRefPubMedPubMedCentralGoogle Scholar
  47. 47.
    Zalewski P, Talaczyńska A, Korban P, Garbacki P, Mizera M, Cielecka-Piontek J (2014) Chromatographia 77:1483–1487. CrossRefPubMedPubMedCentralGoogle Scholar
  48. 48.
    Garbacki P, Zalewski P, Skibiński R, Kozak M, Ratajczak M, Lewandowska K, Bednarski W, Podborska A, Mizera M, Jelińska A, Cielecka-Piontek J (2015) X-Ray Spectrom 44:344–350. CrossRefGoogle Scholar
  49. 49.
    Paczkowska M, Zalewski P, Garbacki P, Talaczyńska A, Krause A, Cielecka-Piontek J (2014) Chromatographia 77:1497–1501. CrossRefPubMedPubMedCentralGoogle Scholar
  50. 50.
    Talaczyńska A, Lewandowska K, Garbacki P, Zalewski P, Skibiński R, Miklaszewski A, Mizera M, Cielecka-Piontek J (2016) Drug Dev Ind Pharm 42:238–244. CrossRefPubMedGoogle Scholar
  51. 51.
    Zalewski P, Skibiński R, Paczkowska M, Garbacki P, Talaczyńska A, Cielecka-Piontek J, Jelińska A (2016) Drug Dev Ind Pharm 42:572–577. CrossRefPubMedGoogle Scholar
  52. 52.
    Zalewski P, Skibiński R, Szymanowska-Powałowska D, Piotrowska H, Kozak M, Pietralik Z, Bednarski W, Cielecka-Piontek J (2016) J Pharm Biomed Anal 118:410–416. CrossRefPubMedGoogle Scholar
  53. 53.
    Zalewski P, Skibiński R, Talaczyńska A, Paczkowska M, Garbacki P, Cielecka-Piontek J (2015) J Pharm Biomed Anal 114:222–226. CrossRefPubMedGoogle Scholar
  54. 54.
    Tam J, Ahmad IAH, Blasko A (2018) J Pharm Biomed Anal 155:288–297. CrossRefPubMedGoogle Scholar
  55. 55.
    Mehmet G, Gokhan CM, Feyyaz O, A. OS (2018) Biomed Chromatogr 32:e4158. DOICrossRefGoogle Scholar
  56. 56.
    Defaix C, Solgadi A, Pham TH, Gardier AM, Chaminade P, Tritschler L (2018) J Pharm Biomed Anal 152:31–38. CrossRefPubMedGoogle Scholar
  57. 57.
    Zhang Y, Zou Z, Chou G (2018) Anal Methods 10:1325–1330. CrossRefGoogle Scholar
  58. 58.
    Wu Y, Guo H, Bu J, Tan Y, Zhong J, Zhao Q (2018) J Chromatogr B: Anal Technol Biomed Life Sci 1076:22–28. CrossRefGoogle Scholar
  59. 59.
    Yıldırım S, Ulaş Çolak N, Yaşar A (2018) J Liq Chromatogr Relat Technol 41:66–72. CrossRefGoogle Scholar
  60. 60.
    Armentano A, Summa S, Lo Magro S, Palermo C, Nardiello D, Centonze D, Muscarella M (2018) J Chromatogr A 1531:46–52. CrossRefPubMedGoogle Scholar
  61. 61.
    Patel B, Wene D, Fan ZT (2017) J Pharm Biomed Anal 146:15–23. CrossRefPubMedGoogle Scholar
  62. 62.
    Akula VK, Sinha BN, Seok HJ (2017) Indian J Pharm Educ Res 51:S769–S775. CrossRefGoogle Scholar
  63. 63.
    Michael AM, Shalliker RA (2017) Anal Methods 9:4514–4519. CrossRefGoogle Scholar
  64. 64.
    Kastner P, Pilarova P, Nejedly T, Machacek M, Klimes J (2017) Curr Pharm Anal 13:250–255. CrossRefGoogle Scholar
  65. 65.
    Czerniak K, Cielecka-Piontek J, Zalewski P (2017) Acta Poloniae Pharmaceutica Drug Res 74:1637–1643Google Scholar
  66. 66.
    Zheng L, Huo XK, Wang C, Cong HJ, Xiang T, Wu B, Zhang BJ, Huang SS, Zhang L, Ma XC (2016) Anal Methods 8:3359–3365. CrossRefGoogle Scholar
  67. 67.
    Ragab GH, Saleh HM, El-Henawee MM, Elsayed OF (2016) J Appl Pharm Sci 6:064–071. CrossRefGoogle Scholar
  68. 68.
    Montemurro M, De Zan MM, Robles JC (2016) J Pharm Anal 6:103–111. CrossRefPubMedGoogle Scholar
  69. 69.
    Mohamed AMI, Abdel-Wadood HM, Mousa HS (2016) New J Chem 40:8424–8437. CrossRefGoogle Scholar
  70. 70.
    Kučera L, Fanali S, Aturki Z, Pospíšil T, Bednář P (2016) J Chromatogr A 1428:126–133. CrossRefPubMedGoogle Scholar
  71. 71.
    Jiang H, Liao X, Wood CM, Xiao CW, Feng YL (2016) J Chromatogr B: Anal Technol Biomed Life Sci 1012–1013:106–112. CrossRefGoogle Scholar
  72. 72.
    Ishihara Y, Sugita H, Takano J, Kitami H (2016) Bunseki Kagaku 65:87–92. CrossRefGoogle Scholar
  73. 73.
    Fontana AR, Antoniolli A, Bottini R (2016) Food Chem 192:1–8. CrossRefPubMedGoogle Scholar
  74. 74.
    Fibigr J, Šatínský D, Havlíková L, Solich P (2016) J Pharm Biomed Anal 120:383–390. CrossRefPubMedGoogle Scholar
  75. 75.
    Bertolini T, Vicentini L, Boschetti S, Andreatta P, Gatti R (2016) J Pharm Biomed Anal 129:198–202. CrossRefPubMedGoogle Scholar
  76. 76.
    Baghdikian B, Filly A, Fabiano-Tixier AS, Petitcolas E, Mabrouki F, Chemat F, Ollivier E (2016) C R Chim 19:692–698. CrossRefGoogle Scholar
  77. 77.
    Ali I, Rani D, Al-Othman ZA (2016) J Liq Chromatogr Relat Technol 39:339–345. CrossRefGoogle Scholar
  78. 78.
    Song Q, Song Y, Zhang N, Li J, Jiang Y, Zhang K, Zhang Q, Tu P (2015) RSC Adv 5:57372–57382. CrossRefGoogle Scholar
  79. 79.
    Mizera M, Talaczyńska A, Zalewski P, Skibiński R, Cielecka-Piontek J (2015) Talanta 137:174–181. CrossRefPubMedGoogle Scholar
  80. 80.
    Marley A, Stalcup AM, Connolly D (2015) J Pharm Biomed Anal 102:261–266. CrossRefPubMedGoogle Scholar
  81. 81.
    Mahesh HRK, Sudhakar Babu K (2015) Res J Pharm Technol 8:172–176. CrossRefGoogle Scholar
  82. 82.
    Gumustas M, Coskun G, Ozkan SA (2015) Rev Roum Chim 60:477–490Google Scholar
  83. 83.
    Gumustas M, Alshana U, Ertas N, Goger NG, Ozkan SA, Uslu B (2015) Journal of Pharmaceutical and Biomedical Analysis.
  84. 84.
    Gras CC, Carle R, Schweiggert RM (2015) J Food Compos Anal 44:170–177. CrossRefGoogle Scholar
  85. 85.
    Feng YL, Liao X, Grenier G, Nguyen N, Chan P (2015) Anal Methods 7:8048–8059. CrossRefGoogle Scholar
  86. 86.
    Chebrolu KK, Yousef GG, Park R, Tanimura Y, Brown AF (2015) J Chromatogr B: Anal Technol Biomed Life Sci 1001:41–48. CrossRefGoogle Scholar
  87. 87.
    Vetter F, Pohl J, Pohl B, Bracher F (2014) Pharmazie 69:455–457. CrossRefPubMedGoogle Scholar
  88. 88.
    Tölgyesi T, Tölgyesi L, Békési K, Sharma VK, Fekete J (2014) Meat Sci 96:1332–1339. CrossRefPubMedGoogle Scholar
  89. 89.
    Tölgyesi T, Sharma VK, Fekete J (2014) J Pharm Biomed Anal 88:45–52. CrossRefPubMedGoogle Scholar
  90. 90.
    Saraiva FRS, Inoue TY, Camargo SS, Malheiros A, da Silva RML, Bresolin TMB (2014) Curr Pharm Anal 10:169–174. CrossRefGoogle Scholar
  91. 91.
    Martano G, Bojaxhi E, Forstenlehner IC, Huber CG, Bresgen N, Eckl PM, Stutz H (2014) Anal Bioanal Chem 406:2909–2924. CrossRefPubMedPubMedCentralGoogle Scholar
  92. 92.
    Hurtado-Sánchez MDC, Espinosa-Mansilla A, Rodríguez-Cáceres MI, Durán-Merás I (2014) J Agric Food Chem 62:97–106. CrossRefGoogle Scholar
  93. 93.
    Gómez-Caravaca AM, Verardo V, Berardinelli A, Marconi E, Caboni MF (2014) J Chromatogr A 1355:134–142. CrossRefPubMedGoogle Scholar
  94. 94.
    Acquaviva A, Romero L, Castells C, Ramis-Ramos G, Herrero-Martinez JM (2014) Anal Methods 6:5830–5837. CrossRefGoogle Scholar
  95. 95.
    Yamamori K, Watanabe T, Inada M, Wakayama T, Kanda M, Nakate T, Kitamura S (2013) Bunseki Kagaku 62:333–338. CrossRefGoogle Scholar
  96. 96.
    Tölgyesi Á, Kunsági Z (2013) Microchem J 106:300–306. CrossRefGoogle Scholar
  97. 97.
    Mao J, Lei S, Yang X, Xiao D (2013) Food Control 32:505–511. CrossRefGoogle Scholar
  98. 98.
    La Nasa J, Ghelardi E, Degano I, Modugno F, Colombini MP (2013) J Chromatogr A 1308:114–124. CrossRefPubMedGoogle Scholar
  99. 99.
    Kučerová B, Krčmová L, Solichová D, Plíšek J, Solich P (2013) J Sep Sci 36:2223–2230. CrossRefPubMedGoogle Scholar
  100. 100.
    Judge MD, Aab C (2013) Can J Chem 91:352–356. CrossRefGoogle Scholar
  101. 101.
    Bardarov V, Dinchev D, Bardarov K (2013) J Univ Chem Technol Metall 48:341–346Google Scholar
  102. 102.
    Tzanavaras PD, Karakosta TD, Rigas PG, Themelis DG, Zotou A (2012) Cent Eur J Chem 10:1459–1463. CrossRefGoogle Scholar
  103. 103.
    Tölgyesi Á, Sharma VK, Fekete S, Lukonics D, Fekete J (2012) J Chromatogr B: Anal Technol Biomed Life Sci 906:75–84. CrossRefGoogle Scholar
  104. 104.
    Tölgyesi Á, Sharma VK, Fekete S, Fekete J, Simon A, Farkas S (2012) J Pharm Biomed Anal 64–65:40–48. CrossRefPubMedGoogle Scholar
  105. 105.
    Tölgyesi Á, Fekete J, Fekete S, Sharma VK, Békési K, Tóth E (2012) J Chromatogr Sci 50:190–198. CrossRefPubMedGoogle Scholar
  106. 106.
    Hroch M, Havlínová Z, Nobilis M, Chládek J (2012) J Chromatogr B: Anal Technol Biomed Life Sci 880:90–99. CrossRefGoogle Scholar
  107. 107.
    Baecher S, Leinenbach A, Wright JA, Pongratz S, Kobold U, Thiele R (2012) Clin Biochem 45:1491–1496. CrossRefPubMedGoogle Scholar
  108. 108.
    Samanidou VF, Karageorgou EG (2011) Drug Testing Analysis 3:234–244. CrossRefPubMedGoogle Scholar
  109. 109.
    Koerner PJ, Jarrett D, Layne J (2011) LCGC N Am 29:44–46Google Scholar
  110. 110.
    Abrahim A, Al-Sayah M, Skrdla P, Bereznitski Y, Chen Y, Wu N (2010) J Pharm Biomed Anal 51:131–137. CrossRefPubMedGoogle Scholar
  111. 111.
    Wang S, Wen J, Cui L, Zhang X, Wei H, Xie R, Feng B, Wu Y, Fan G (2010) J Pharm Biomed Anal 51:889–893. CrossRefPubMedGoogle Scholar
  112. 112.
    Zheng J, Patel D, Tang Q, Markovich RJ, Rustum AM (2009) J Pharm Biomed Anal 50:815–822. CrossRefPubMedGoogle Scholar
  113. 113.
    Hsieh Y, Duncan CJG, Brisson J-M (2007) Anal Chem 79:5668–5673. CrossRefPubMedGoogle Scholar
  114. 114.
    Rogers LA, Crews KE, Long SG, Patterson KM, McCune JE (2009) J Liq Chromatogr Relat Technol 32:2246–2264. CrossRefGoogle Scholar
  115. 115.
    Vass A, Robles-Molina J, Perez-Ortega P, Gilbert-Lopez B, Dernovics M, Molina-Diaz A, Garcia-Reyes JF (2016) Anal Bioanal Chem 408:4857–4869. CrossRefPubMedGoogle Scholar
  116. 116.
    Chauve B, Guillarme D, Cleon P, Veuthey JL (2010) J Sep Sci 33:752–764. CrossRefPubMedGoogle Scholar
  117. 117.
    Paczkowska M, Mizera M, Tężyk A, Zalewski P, Dzitko J, Cielecka-Piontek JA J Chem.
  118. 118.
    Gumustas M, Ozkan SA, Chankvetadze B (2016) J Chromatogr A 1467:297–305. CrossRefPubMedGoogle Scholar
  119. 119.
    Bezhitashvili L, Bardavelidze A, Ordjonikidze T, Chankvetadze L, Chity M, Farkas T, Chankvetadze B (2017) J Chromatogr A 1482:32–38. CrossRefPubMedGoogle Scholar
  120. 120.
    Chankvetadze B (2012) J Chromatogr A 1269:26–51. CrossRefPubMedGoogle Scholar
  121. 121.
    Chankvetadze B (2017) Liquid chromatographic separation of enantiomers. In: Liquid chromatography: applications, 2. Elsevier Inc., Oxford, pp. 69–86Google Scholar
  122. 122.
    D’Orazio G, Fanali C, Karchkhadze M, Chankvetadze B, Fanali S (2017) J Chromatogr A 1520:127–134. CrossRefPubMedGoogle Scholar
  123. 123.
    Khatiashvili T, Kakava R, Matarashvili I, Tabani H, Fanali C, Volonterio A, Farkas T, Chankvetadze B (2018) J Chromatogr A 1545:59–66. CrossRefPubMedGoogle Scholar
  124. 124.
    Lomsadze K, Jibuti G, Farkas T, Chankvetadze B (2012) J Chromatogr A 1234:50–55. CrossRefPubMedGoogle Scholar
  125. 125.
    Shedania Z, Kakava R, Volonterio A, Farkas T, Chankvetadze B (2018) J Chromatogr A 1557:62–74. CrossRefPubMedGoogle Scholar
  126. 126.
    Cabooter D, Fanigliulo A, Bellazzi G, Allieri B, Rottigni A, Desmet G (2010) J Chromatogr A 1217:7074–7081. CrossRefPubMedGoogle Scholar
  127. 127.
    Gritti F, Perdu MA, Guiochon G (2012) J Chromatogr A 1229:148–155. CrossRefPubMedGoogle Scholar
  128. 128.
    Wu X, You L, Di B, Hao W, Su M, Gu Y, Shen L (2013) J Chromatogr A 1299:78–84. CrossRefPubMedGoogle Scholar
  129. 129.
    Alessia C, IO H, Giulia M, Claudio V, Francesco G (2018) J Sep Sci 41:1307–1318. DOICrossRefGoogle Scholar
  130. 130.
    Catani M, Felletti S, Ismail OH, Gasparrini F, Pasti L, Marchetti N, De Luca C, Costa V, Cavazzini A (2018) Anal Bioanal Chem 410:2457–2465. CrossRefPubMedGoogle Scholar
  131. 131.
    Bezhitashvili L, Bardavelidze A, Mskhiladze A, Gumustas M, Ozkan SA, Volonterio A, Farkas T, Chankvetadze B (2018) J Chromatogr A 1571:132–139. CrossRefPubMedGoogle Scholar
  132. 132.
    Takeuchi T (2003) Anal Bioanal Chem 375:26–27. CrossRefPubMedGoogle Scholar
  133. 133.
    Bruns S, Grinias JP, Blue LE, Jorgenson JW, Tallarek U (2012) Anal Chem 84:4496–4503. CrossRefPubMedPubMedCentralGoogle Scholar
  134. 134.
    Avery RG, Ramsay JDF (1973) J Colloid Interface Sci 42:597–606. CrossRefGoogle Scholar
  135. 135.
    Colon LA, Maloney TD, Fermier AM (2000) J Chromatogr A 887:43–53CrossRefGoogle Scholar
  136. 136.
    Boughtflower RJ, Underwood T, Paterson CJ (1995) Chromatographia 40:329–335. CrossRefGoogle Scholar
  137. 137.
  138. 138.
    Unger KK, Skudas R, Schulte MM (2008) J Chromatogr A 1184:393–415. CrossRefPubMedGoogle Scholar
  139. 139.
    Fanali C, Rocco A, Aturki Z, Mondello L, Fanali S (2012) J Chromatogr A 1234:38–44. CrossRefPubMedGoogle Scholar
  140. 140.
    Fanali S, D’Orazio G, Farkas T, Chankvetadze B (2012) Journal of chromatography. A 1269:136–142. CrossRefGoogle Scholar
  141. 141.
    Fanali S, Rocchi S, Chankvetadze B (2013) Electrophoresis 34:1737–1742. CrossRefPubMedGoogle Scholar
  142. 142.
    Wagner BM, Schuster SA, Boyes BE, Kirkland JJ (2012) J Chromatogr A 1264:22–30. CrossRefPubMedPubMedCentralGoogle Scholar
  143. 143.
    Ruta J, Guillarme D, Rudaz S, Veuthey JL (2010) J Sep Sci 33:2465–2477. CrossRefPubMedGoogle Scholar
  144. 144.
    Ruta J, Zurlino D, Grivel C, Heinisch S, Veuthey JL, Guillarme D (2012) J Chromatogr A 1228:221–231. CrossRefPubMedGoogle Scholar
  145. 145.
  146. 146.
    Preti R, Antonelli ML, Bernacchia R, Vinci G (2015) Food Chem 187:555–562. CrossRefPubMedGoogle Scholar
  147. 147.
    Vinci G, Antonelli ML, Preti R (2013) J Sep Sci 36:461–468. CrossRefPubMedGoogle Scholar
  148. 148.
    Zhang P, Bui A, Rose G, Allinson G (2014) Journal of chromatography. A 1325:56–64. CrossRefGoogle Scholar
  149. 149.
    Marhol P, Gazak R, Bednar P, Kren V (2011) J Sep Sci 34:2206–2213. CrossRefPubMedGoogle Scholar
  150. 150.
    Gritti F, Guiochon G (2014) J Chromatogr A 1333:60–69. CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Forensic Toxicology, Institute of Forensic SciencesAnkara UniversityAnkaraTurkey
  2. 2.Department of Pharmacognosy, Faculty of PharmacyPoznan University of Medical SciencesPoznanPoland
  3. 3.Department of Analytical Chemistry, Faculty of PharmacyAnkara UniversityAnkaraTurkey

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