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Retention Modeling of Gradient Elutions: Application of Iso-to-Grad Approach for LC Systems with Dual-Species Eluent

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Abstract

Development of new chromatographic method is often time-consuming and may be shortened by mathematical modeling. Unfortunately, many of the models are limited for predefined elution programs only. The integral model uses iso-to-grad approach to transfer information from isocratic to gradient elution without such limitations, which was successfully tested for IC and HPLC using single-species eluents. Here its applicability was tested on systems using more complex eluents. An HPLC analysis of emerging contaminants using methanol/acetonitrile/water eluent was performed. Four different integral models were developed and validated. The models showed good predictive ability.

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References

  1. Schoenmakers PJ, Billiet HAH, Tijssen R, De Galan LJ (1978) J Chromatogr 149:519–537

    Article  CAS  Google Scholar 

  2. Snyder LR, Dolan JW, Gant JR (1979) J Chromatogr A 165:3–30. https://doi.org/10.1016/S0021-9673(00)85726-X

    Article  CAS  Google Scholar 

  3. Hoover TB (1982) Sep Sci Technol 17:295–305

    Article  CAS  Google Scholar 

  4. Jenke DR, Pagenkopf GK (1984) Anal Chem 56:85–88

    Article  CAS  Google Scholar 

  5. Jenke DR, Pagenkopf GK (1984) Anal Chem 56:88–91

    Article  CAS  Google Scholar 

  6. Jenke DR (1984) Anal Chem 56:2674–2681

    Article  CAS  Google Scholar 

  7. Maruo M, Hirayama N, Kuwamoto T (1989) J Chromatogr 481:315–322

    Article  CAS  Google Scholar 

  8. Hajós P, Horváth O, Denke V (1995) Anal Chem 67:434–441

    Article  Google Scholar 

  9. Madden JE, Haddad PR (1998) J Chromatogr A 829:65–80

    Article  CAS  Google Scholar 

  10. Srečnik G, Debeljak Ž, Cerjan-Stefanović Š, Novič M, Bolanča T (2002) J Chromatogr A 973:47–59

    Article  PubMed  Google Scholar 

  11. Madden JE, Shaw MJ, Dicinoski GW, Avdalovic N, Haddad PR (2002) Anal Chem 74:6023–6030

    Article  CAS  PubMed  Google Scholar 

  12. Bolanča T, Cerjan-Stefanović Š, Regelja M, Regelja H, Lončarić S (2005) J Chromatogr A 1085:74–85. https://doi.org/10.1016/j.chroma.2005.02.018

    Article  CAS  PubMed  Google Scholar 

  13. Jandera P, Churáček J (1974) J Chromatogr A 91:207–221

    Article  CAS  Google Scholar 

  14. Rocklin RD, Pohl CA, Schibler JA (1987) J Chromatogr 411:107–119

    Article  CAS  Google Scholar 

  15. Vivó-Truyols G, Torres-Lapasió J, García-Alvarez-Coque M (2003) J Chromatogr A 1018:169–181

    Article  CAS  PubMed  Google Scholar 

  16. Shellie RA, Ng BK, Dicinoski GW, Poynter SDH, O’Reilly JW, Pohl CA, Haddad PR (2008) Anal Chem 80:2474–2482

    Article  CAS  PubMed  Google Scholar 

  17. Bolanča T, Cerjan-Stefanović Š, Luša M, Rogošić M, Ukić Š (2006) J Chromatogr A 1121:228–235

    Article  CAS  PubMed  Google Scholar 

  18. Bolanča T, Ukić Š, Rogošić M (2010) J Liq Chromatogr Relat Technol 33:1831–1841. https://doi.org/10.1080/10826076.2010.532707

    Article  CAS  Google Scholar 

  19. Tanaka N, Goodell H, Karger BL (1978) J Chromatogr A 158:233–248. https://doi.org/10.1016/S0021-9673(00)89970-7

    Article  CAS  Google Scholar 

  20. Massart DL, Vandeginste BGM, Buydens LMC, de Jong S, Lewi PJ, Smeyers-Verbeke J (1998) Handbook of chemometrics and qualimetrics, Part A. Elsevier, Amsterdam

    Google Scholar 

Download references

Funding

This study was funded by Croatian Science Foundation through project entitled Modeling of Environmental Aspects of Advanced Water Treatment for Degradation of Priority Pollutants (MEAoWT) (IP-09-2014-7992).

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Authors and Affiliations

  1. Sample Control d.o.o., Franje Puškarića 18, 10000, Zagreb, Croatia

    Vladimir Stankov

  2. Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 19, 10000, Zagreb, Croatia

    Matija Cvetnić, Mirjana Novak Stankov, Marko Rogošić, Tomislav Bolanča & Šime Ukić

Authors
  1. Vladimir Stankov
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  2. Matija Cvetnić
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  3. Mirjana Novak Stankov
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  4. Marko Rogošić
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  5. Tomislav Bolanča
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  6. Šime Ukić
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Corresponding author

Correspondence to Šime Ukić.

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The authors declare that they have no conflict of interest.

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This article does not contain any studies with human participants or animals performed by any of the authors.

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Published in the topical collection 24th International Symposium on Separation Sciences combined with 21st International Conference Analytical Methods and Human Health with guest editors Milan Hutta and Dušan Berek.

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Stankov, V., Cvetnić, M., Novak Stankov, M. et al. Retention Modeling of Gradient Elutions: Application of Iso-to-Grad Approach for LC Systems with Dual-Species Eluent. Chromatographia 82, 749–755 (2019). https://doi.org/10.1007/s10337-018-3648-4

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  • DOI: https://doi.org/10.1007/s10337-018-3648-4

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