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Chromatographia

, Volume 81, Issue 11, pp 1579–1587 | Cite as

Magnetic Field-Assisted Direct Immersion SPME of Endogenous Aldehydes in Human Urine

  • Alireza GhiasvandEmail author
  • Nahid Heidari
  • Sana Abdolhosseini
Original
  • 83 Downloads

Abstract

Direct immersion solid-phase microextraction (DI-SPME) is an effective microsampling strategy for polar and ionic species in aqueous media. Nevertheless, the fiber coating is in direct contact with sample solution and affected by its conditions. To compensate this limitation and to improve the extraction efficiency, a magnetic fiber coating was prepared and employed for DI-SPME sampling under the enhancing effect of a magnetic field. Magnetic iron oxide core–shell silica nanoparticles were synthesized and embedded in polypyrrole using an in situ electropolymerization method along with simultaneous coating on the surface of a platinized stainless-steel fiber. It was then applied for magnetic-assisted DI-SPME (MA-DI-SPME) sampling of endogenous aldehydes in human urine. Sample solution pH, the magnetic field intensity, ionic strength and extraction time were evaluated as the important affecting variables. Limits of detection were obtained 0.01–0.1 ng mL−1; the calibration graphs were linear over the range of 0.1–10000 ng mL−1. The inter-fiber (fiber-to-fiber) reproducibility was found to be 10.7–12.5%. Matrix effect from urine samples was not observed at concentration levels of 0.2, 2, and 8 µg mL−1. The results showed that magnetic field increased the efficiency of DI-SPME method about two to four times. The developed strategy was successfully applied for the extraction and quantification of hexanal and heptanal (as the most important aldehyde biomarkers) in urine samples.

Graphical Abstract

Keywords

Magnetic-assisted direct-immersion SPME Aldehyde biomarkers Urine Hexanal Heptanal 

Notes

Acknowledgements

The authors are grateful to Mr. Givekesh and Mr. Torabi (Electronic Technicians) for their constructive helps for fabrication of the electromagnet. The authors also sincerely acknowledge Sina Pathobiology Laboratory for providing urine samples.

Funding

This study was not funded by any grants.

Compliance with Ethical Standards

Conflict of Interest

The authors have no conflict of interest to declare.

Ethical Approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Supplementary material

10337_2018_3620_MOESM1_ESM.pdf (416 kb)
Supplementary material 1 (PDF 415 KB)

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of ChemistryLorestan UniversityKhorramabadIran

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