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Chromatographia

, Volume 78, Issue 19–20, pp 1263–1270 | Cite as

Nonderivatized Sarcosine Analysis by Gas Chromatography after Solid-Phase Microextraction by Newly Synthesized Monolithic Molecularly Imprinted Polymer

  • Hamid Hashemi-Moghaddam
  • Mohammad Hagigatgoo
Original

Abstract

In this study, a simple method for analysis of nonderivatized sarcosine was developed by gas chromatography. It is based on solid-phase microextraction of sarcosine on a novel synthesized solid-phase microextraction (SPME) fiber. A monolithic SPME fiber was fabricated based on a molecularly imprinted polymer that could be coupled with gas chromatography for extraction and determination of sarcosine. Extraction time, pH, and ionic strength were investigated as important factors in the extraction procedure. The fabricated fiber was firm, inexpensive, stable, and selective, which are vital characteristics for SPME. The selectivity of the fabricated fiber in relation to analog compounds was also investigated. Under optimum conditions, the calibration curve was linear in the range of 1–100 mg L−1 (R 2 = 0.987). High extraction efficiency for sarcosine was obtained with a detection limit of 0.37 mg L−1. The fabricated fiber was successfully applied for SPME of sarcosine from urine after its extraction, followed by gas chromatography flame ionization detector analysis.

Keywords

Gas chromatography Sarcosine Molecularly imprinted polymer Solid-phase microextraction 

Notes

Acknowledgments

We are grateful to the Laboratory Complex of Damghan Branch, Islamic Azad University and Pars Material Research and Testing (PMRT) for valuable technical assistance.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Chemistry, Damghan BranchIslamic Azad UniversityDamghanIran

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