Abstract
Liquid chromatography (LC) is a separation technique used in many different areas to aid the identification and quantification of substances in various matrices. LC techniques with various detection modes have been widely used for the sensitive and selective determination of trace amounts of pharmaceutical active compounds in biological samples and their dosage forms. A completely new system design with advanced technology has been developed, called ultra high performance liquid chromatography, which has evolved from high performance liquid chromatography. The application of LC methods to drug analysis introduces a powerful tool for therapeutic drug monitoring as well as for clinical research. The advantages of short turnaround time, method reliability, method sensitivity, and drug specificity justify the use of LC techniques for various groups of the drug active compounds. This review describes some of the principles of ultra high performance liquid chromatography and high performance liquid chromatography, validation of these methods, system suitability tests for the methods, and application of methods to pharmaceutical analysis in the last 3 years.
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References
Swartz ME, Murphy B (2005) Am Lab 37:22–27
Swartz ME, Murphy B (2004) Lab Plus Int 18:6–9
Jerkovich AD, Mellors JS, Jorgenson JW (2003) LCGC 21:600–610
Zotou A (2012) Cent Eur J Chem 10:554–569
Neue U (1997) HPLC columns: theory, technology and practice. Wiley, New York
Shen Y, Zhang R, Moore RJ, Kim J, Metz TO, Hixson KK, Zhao R, Livesay EA, Udseth HR (2005) Smith RD Anal Chem 77:3090–3100
Shen Y, Smith RD, Unger KK, Kumar D (2005) Anal Chem 77:6692–6701
Van Deemter JJ, Zuiderweg FJ, Klingengerg A (1956) J Chem Eng Sci 5:271–289
Novakova L, Matysova L, Solich P (2006) Talanta 68:908–918
Reddy TSK, Balammal G, Kumar AS (2012) Int J Pharm Res Anal 2:24–31
Wu N, Lippert JA, Lee ML (2001) J Chromatogr A 911:55–60
Tolley L, Jorgenson JW, Mosely MA (2001) Anal Chem 73:2985–2991
Swartz ME (2005) LCGC Supplement:10–20
Neue UD, Walter TH, Alden BA, Jiang Z, Fisk RP, Cook JT, Glose KH, Carmody JL, Grassi JM, Cheng YF, Lu Z, Crowley RJ (1999) Am Lab 31:36–39
Cheng YF, Walter TH, Lu Z, Iraneta P, Gendreau C, Neue UD, Grassi JM, Carmody JL, O’Gara JE, Fisk RP (2000) LCGC 18:1162–1173
Patel KD, Jerkovich AD, Link JC, Jorgenson JW (2004) Anal Chem 76:5777–5786
Colon LA, Cintron JM, Anspach JA, Fermier AM, Swinney KA (2004) Analyst 129:503–504
Roge AB, Firke SN, Dhane RM, Gunjkar VJ, Vadvalkar SM (2011) Int J PharmTech Res 3:1423–1429
Srivastava B, Sharma BK, Baghel US, Yashwant, Sethi N (2010) Int J Pharm Qual Ass 2:19–25
Swartz ME (2005) J Liq Chromatogr Rel Technol 28:1253–1263
Xiang Y, Liu Y, Stearns SD, Plistil A, Brisbin MP, Lee ML (2006) Anal Chem 78:858–864
Anspach JA, Maloney TD, Brice RW, Colon LA (2005) Anal Chem 77:7489–7494
Patil VP, Tathe RD, Devdhe SJ, Angadi SS, Kale SH (2011) Int Res J Pharm 2:39–44
Plumb RS, Castro-Perez J, Granger JH, Beattie I, Joncour K, Wright A (2004) Rapid Commun Mass Spectrom 18:2331–2337
Ermer J, Miller JHMCB (2005) Method validation in pharmaceutical analysis. Wiley-VCH, Weinheim
Riley CM, Rosanske TW (1996) Development and validation of analytical methods Pergamon Press, Oxford
ICH Guideline Q2A (R1) (2005) Validation of analytical procedures: text and methodology, November
Guidelines for Submitting Samples and Validation Data for Methods Validation US Food and Drug Administration (1987) Center for Drug and Biologics Department of Health and Human Services
The Third International Conference on Harmonization of Technical Requirements for Registration on Pharmaceuticals for Human Use (1995) Validation of analytical procedures: methodology, announcements, Jokohama, Japan
ICH Guideline Q2B (1996) Validation of analytical procedures: methodology, November
The United States Pharmacopoeia USP 23 (1994) Validation of compendial methods, General information <1225>. The United States Pharmacopoeial Convention Inc, Taunton, MA
Ronald E M (2011) LC-GC Europe. August 1
Clarke A, Nightingale J, Mukherjee P, Petersson P (2012) Chromatography Today. May/June
Guillarme D, Veuthey J (2009) Technical note 008383_02 Thermo Technical Notes
Easy Method Transfer from HPLC to RSLC with the dionex method speed-up calculator. Dionex Technical Note 75
Michael S (2007) “HPLC to UPLC method migration: an overview of key considerations and available tools” Waters
Systematic Transfer of HPLC Methods to UHPLC (2008) Restek Technical Note
Kukusamude C, Burakham R, Chailapakul O, Srijaranai S (2012) Talanta 92:38–44
Alarfaj NA (2012) J Saudi Chem Soc 16:23–30
Giorgi M, Meizler A, Mills PC (2012) J Pharm Biomed Anal 67–68:148–153
Talluri MVNK, Bairwa MK, Dugga HHT, Srinivas R (2012) J Liq Chromatogr Rel Technol 35:129–140
Shaalan RA, Belal TS (2012) J Liq Chromatogr Rel Technol 35:215–230
Pujeri SS, Khader AMA, Seetharamappa J (2012) J Liq Chromatogr Rel Technol 35:40–49
Javed S, Kohli K, Ali M (2012) J Liq Chromatogr Rel Technol 35:473–485
Patel A, Macwana C, Parmar V, Patel S (2012) J AOAC Int 95:419–423
Thomas S, Shandilya S, Bharti A, Agarwal A (2012) J Pharm Biomed Anal 58:136–140
Chen W, Shen Y, Rong H, Lei L, Guo S (2012) J Pharm Biomed Anal 59:179–183
Park M, Ahn S (2012) J Forensic Sci 57:1637–1640
Zhang W, Liu Y, Yang H, Li Z, Huang Y, Xu Z, Lin Y, Xiang Q, Pang J (2012) J Chromatogr B 885–886:24–29
Wang Y, Zhang P, Jiang N, Gong X, Meng L, Wang D, Ou N, Zhang H (2012) J Chromatogr B 899:27–30
Li J, Wang L, Chen Z, Xie R, Li Y, Hang T, Fan G (2012) J Chromatogr B 895–896:83–88
Khanavi M, Hajimahmoodi M, Ranjbar AM, Oveisi MR, Ardekani MRS, Mogaddam G (2012) Food Anal Method 5:408–415
Serna-Jimenez CE, Sancho SD, Calatayud-Pascual MA, Balaguer-Fernandez C, Femenia-Font A, Lopez-Castellano A, Merino V (2012) Biomed Chromatogr 26:769–774
Kumar SV, Rudresha G, Gurav S, Zainuddin M, Dewang P, Kethiri RR, Rajagopal S, Mullangi R (2012) Biomed Chromatogr 27:203–207
Kamal YT, Mohammed Musthaba S, Singh M, Parveen R, Ahmad S, Baboota S, Ali I, Siddiqui KM, Arif Zaidi SM (2012) Biomed Chromatogr 26:1183–1190
Hatami M, Farhadi K (2012) Biomed Chromatogr 26:875–880
Hassan MG, Emara KM, Mohamed HA, Abdel-Wadood HM, Ikeda R, Wada M, Kuroda N, Nakashima K (2012) Biomed Chromatogr 26:214–219
Gounder MK, Lin H, Stein M, Goodin S, Bertino JR, Kong AN, DiPaola RS (2012) Biomed Chromatogr 26:650–654
Li N, Nian L, Zhang R, Wu S, Ren R, Wang Y, Zhang H, Yu A (2013) Talanta 105:219–228
Heidari H, Razmi H (2012) Talanta 99:13–21
Xia Y, Wu C, Liu W, Feng F, Li Z (2012) J Pharm Biomed Anal 71:168–172
Wang C, Garcia-Contreras L, Muttil P, Hickey AJ (2012) J Pharm Biomed Anal 60:1–6
Suh JH, Lee YY, Lee HJ, Kang M, Hur Y, Lee SN, Yang D-H, Han SB (2013) J Pharm Biomed Anal 75:214–219
Rafamantanana MH, Debrus B, Raoelison GE, Rozet E, Lebrun P, Uverg-Ratsimamanga S, Hubert P, Quetin-Leclercq J (2012) J Pharm Biomed Anal 62:23–32
Moreno IED, da Fonseca BM, Barroso M, Costa S, Queiroz JA, Gallardo E (2012) J Pharm Biomed Anal 61:93–99
Mahmood AH, Medley GA, Grice JE, Liu X, Roberts MS (2012) J Pharm Biomed Anal 62:220–223
Kahsay G, Shraim F, Villatte P, Rotger J, Cassus-Coussere C, Van Schepdael A, Hoogmartens J, Adams E (2013) J Pharm Biomed Anal 75:199–206
Jin P, Xia L, Li Z, Che N, Zou D, Hu X (2012) J Pharm Biomed Anal 70:151–157
De Baere S, Smets P, Finch N, Heiene R, De Backer P, Daminet S, Croubels S (2012) J Pharm Biomed Anal 61:50–56
Baati T, Horcajada P, David O, Gref R, Couvreur P, Serre C (2012) J Pharm Biomed Anal 67–68:98–103
Zheng J, Zhang R, Shao C, Hu Z, Wang D, Yu T, Yan X, Wang Y (2012) J Chromatogr B 903:81–87
Wang Q, Huang L, Yu P, Wang J, Shen S (2013) J Chromatogr 912:33–37
Sun Y, Bu S-J (2012) J Chromatogr B 899:160–162
Rodríguez J, Castañeda G, Muñoz L (2013) J Chromatogr B 15:913–914:12–18
Rodrigues M, Alves G, Rocha M, Queiroz J, Falcão A (2013) J Chromatogr B 913–914:90–97
Moraes ERdS, Grisolia ABA, Oliveira KRM, Picanço-Diniz DLW, Crespo-López ME, Maximino C, Batista EdJO, Herculano AM (2012) J Chromatogr B 907:1–6
Liu X, Zhang Y, Yuan M, Sun Y (2012) J Chromatogr B 907:140–145
Kunicki PK, Waś J (2012) J Chromatogr B 911:133–139
Koeber R, Kluenemann H–H, Waimer R, Koestlbacher A, Wittmann M, Brandl R, Doerfelt A, Jahner T, Melchner D, Haen E (2012) J Chromatogr B 881–882:1–11
Javanbakht M, Moein MM, Akbari-adergani B (2012) J Chromatogr B 911:49–54
Itohda A, Tsutsumi K, Imai H, Iwao M, Kotegawa T, Ohashi K (2012) J Chromatogr B 904:88–92
Hadi H, Makahleh A, Saad B (2012) J Chromatogr B 895–896:131–136
Gao S, You J, Wang Y, Zhang R, Zhang H (2012) J Chromatogr B 887–888:35–42
das Neves J, Sarmento B, Amiji M, Bahia MF (2012) J Chromatogr B 911:76–83
Wang H, Li G, Zhang Y, Chen H, Zhao Q, Song W, Xu Y, Jin H, Ding L (2012) J Chromatogr A 1233:36–43
Gao W, Gray N, Heaton J, Smith NW, Jia Y, Legido-Quigley C (2012) J Chromatogr A 1228:324–328
Frühauf D, Juza M (2012) J Chromatogr A 1269:242–254
Zeng A, Xing J, Wang C, Song J, Li C, Yang X, Yang G (2012) Anal Chim Acta 712:145–151
Liu L, Chen Z (2012) Anal Chim Acta 737:99–104
Gumustas M, Sanli S, Sanli N, Ozkan SA (2012) J Food Drug Anal 20:588–596
Karadas N, Sanli S, Gumustas M, Ozkan SA (2012) J Pharm Biomed Anal 66:116–125
Yang D-Z, An Y-Q, Jiang X-L, Tang D-Q, Gao Y–Y, Zhao H-T, Wu X-W (2011) Talanta 85:885–890
Payán MR, López MÁB, Torres RF, Navarro MV, Mochón MC (2011) Talanta 85:394–399
Kuligowski J, Galera MM, García MDG, Culzoni MJ, Goicoechea HC, Garrigues S, Quintás G, de la Guardia M (2011) Talanta 83:1158–1165
Golabchifar A-A, Rouini M-R, Shafaghi B, Rezaee S, Foroumadi A, Khoshayand M-R (2011) Talanta 85:2320–2329
El-Sayed MA (2011) Talanta 83:717–723
Dönmez ÖA, Aşçı B, Bozdoğan A, Sungur S (2011) Talanta 83:1601–1605
Ahmed S, Atia NN, Mohamed NA (2011) Talanta 84:666–672
Elgawish MS, Mostafa SM, Elshanawane AA (2011) Saudi Pharm J 19:43–49
Kim J-H, Shin IS, Lee YK, Oh HJ, Ban SJ (2011) Osong Public Health and Res Perspect 2:127–134
Li C–C, Farn S-S, Yeh Y-H, Lin W-J, Shen L-H (2011) Nucl Med Biol 38:605–612
Rystov L, Chadwick R, Krock K, Wang T (2011) J Pharm Biomed Anal 56:887–894
Peepliwal A, Bonde CG, Bothara KG (2011) J Pharm Biomed Anal 54:845–849
Nageswara Rao R, Guru Prasad K, Gangu Naidu C, Maurya PK (2011) J Pharm Biomed Anal 56:471–478
Krier F, Brion M, Debrus B, Lebrun P, Driesen A, Ziemons E, Evrard B, Hubert P (2011) J Pharm Biomed Anal 54:694–700
Karthikeyan K, Arularasu GT, Ramadhas R, Pillai KC (2011) J Pharm Biomed Anal 54:850–854
Elmasry MS, Blagbrough IS, Rowan MG, Saleh HM, Kheir AA, Rogers PJ (2011) J Pharm Biomed Anal 54:646–652
Diawara HZ, Gbaguidi F, Evrard B, Leclercq JQ, Moudachirou M, Debrus B, Hubert P, Rozet E (2011) J Pharm Biomed Anal 56:7–15
Collier JW, Shah RB, Bryant AR, Habib MJ, Khan MA, Faustino PJ (2011) J Pharm Biomed Anal 54:433–438
Chryssanthi DG, Lamari FN, Georgakopoulos CD, Cordopatis P (2011) J Pharm Biomed Anal 55:563–568
Chen X, Xia Y, Lu Y, Liang J (2011) J Pharm Biomed Anal 54:406–410
Bazargan M, Davey AK, Muhlhausler BS, Morrison JL, McMillen IC, Foster DJR (2011) J Pharm Biomed Anal 55:360–365
Wang C-H, Wang Y-X, Liu H-J (2011) J Pharm Anal 1:291–296
Liu Y-K, Yan E, Zhan H-Y, Zhang Z-Q (2011) J Pharm Anal 1:13–19
Tá Gondová, Petrovaj J, Suchá M, Armstrong DW (2011) J Liq Chromatogr Rel Technol 34:2304–2314
Zou Y, Shi Y, Bai Y, Tang J, Chen Y, Wang L (2011) J Chromatogr B 879:1809–1812
Zhao X, Shen Q, Ma Y (2011) J Chromatogr B 879:113–116
Zhang Q, Cai D, Liu J (2011) J Chromatogr B 879:2809–2814
Skidan I, Grunwald J, Thekkedath R, Degterev A, Torchilin V (2011) J Chromatogr B 879:1610–1616
Shah Y, Iqbal Z, Ahmad L, Khan A, Khan MI, Nazir S, Nasir F (2011) J Chromatogr B 879:557–563
Pei Q, Yang G-P, Li Z-J, Peng X-D, Fan J-H, Liu Z-Q (2011) J Chromatogr B 879:2000–2004
Muchohi SN, Thuo N, Karisa J, Muturi A, Kokwaro GO, Maitland K (2011) J Chromatogr B 879:146–152
Monticelli E, Aman CS, Costa ML, Rota P, Bogdan D, Allevi P, Cighetti G (2011) J Chromatogr B 879:2764–2771
Lin F, Sherris D, Beijnen JH, Van Tellingen O (2011) J Chromatogr B 879:3823–3831
Garg MB, Sakoff JA, Ackland SP (2011) J Chromatogr B 879:2201–2205
Faivre L, Gomo C, Mir O, Taieb F, Schoemann-Thomas A, Ropert S, Vidal M, Dusser D, Dauphin A, Goldwasser F, Blanchet B (2011) J Chromatogr B 879:2345–2350
Chen J, He H, Li S, Shen Q (2011) J Chromatogr B 879:1967–1972
Calaf R, Cerini C, Génovésio C, Verhaeghe P, Jourde-Chiche N, Bergé-Lefranc D, Gondouin B, Dou L, Morange S, Argilés A, Rathelot P, Dignat-George F, Brunet P, Charpiot P (2011) J Chromatogr B 879:2281–2286
Bai X, Qu J, Lu J, Kano Y, Yuan D (2011) J Chromatogr B 879:395–402
Kong LY, Su BG, Bao ZB, Xing HB, Yang YW, Ren QL (2011) J Chromatogr A 1218:8664–8671
Gao W, Legido-Quigley C (2011) J Chromatogr A 1218:4307–4311
Korany MA, Fahmy OT, Mahgoub H, Maher HM (2011) J Adv Res 2:121–130
Tahmouzi S, Khaksar R, Ghasemlou M (2011) Food Chem 126:756–761
Shalaby AR, Salama NA, Abou-Raya SH, Emam WH, Mehaya FM (2011) Food Chem 124:1660–1666
Ding Y, Wu EQ, Liang C, Chen J, Tran MN, Hong CH, Jang Y, Park KL, Bae K, Kim YH, Kang JS (2011) Food Chem 127:755–760
Bistoletti M, Moreno L, Alvarez L, Lanusse C (2011) Food Chem 126:793–800
Jiang X-H, Yang J-Q, Li N, Wang H, Zhou Q-X (2011) Fitoterapia 82:878–882
Salama I (2011) Bull Fac Pharm Cairo Univ 49:19–24
Jadhav SD, Butle SR, Patil SD, Jagtap PK (2011) Arab J Chem 1–11
Sanli S, Sanli N, Gumustas M, Ozkan SA, Karadas N, Aboul-Enein H (2011) Chromatographia 74:549–558
Sanli N, Sanli S, Sızır U, Gumustas M, Ozkan SA (2011) Chromatographia 73:1171–1176
Demiralay EC, Gumustas M, Canbay H (2011) Pharm Glob (IJCP) 6:1–4
Gumustas M, Ozkan SA (2011) Turk J Pharm Sci 9:161–171
Gumustas M, Ozkan SA (2011) Asian Chem Lett 16:23–30
An G, Morris ME (2010) J Pharm Biomed Anal 51:750–753
Arayne MS, Sultana N, Mirza AZ, Siddiqui FA (2010) J Chromatogr Sci 48:382–385
Arayne MS, Sultana N, Mirza AZ, Siddiqui FA (2010) J Chil Chem Soc 55:156–158
Arayne MS, Sultana N, Zuberi MH, Siddiqui FA (2010) J Chromatogr Sci 48:721–725
Çaglayan MG, Palabiyik IM, Onur F (2010) J AOAC Int 93:862–868
Can NO, Arli G (2010) J AOAC Int 93:1077–1085
Carlucci G, Di Federico L, Iuliani P (2010) J Sep Sci 33:1717–1722
Chen JC, Chen QH, Guo Q, Ruan S, Ruan H, He GQ, Gu Q (2010) Food Chem 122:1247–1252
Dalmora SL, Silva Sangoi MDA, Nogueira DR, Silva LMDA (2010) J AOAC Int 93:523–530
Dixit RP, Barhate CR, Padhye SG, Viswanathan CL, Nagarsenker MS (2010) Indian J Pharm Sci 72:204–210
Dogrukol-Ak D, Yeniceli D (2010) J Liq Chromatogr Rel Technol 33:1745–1759
Eldin AB, Shalaby AA, El Maamly MY (2010) Acta Pharm Sci 52:229–238
El-Sherbiny DT, Abd El-Ghaffar ME, El-Wasseef DR, El-Ashry SM (2010) J Liq Chromatogr Rel Technol 33:1476–1486
Ferrarini A, Huidobro AL, Pellati F, Barbas C (2010) J Pharm Biomed Anal 53:122–129
Flor S, Tripodi V, Scioscia S, Revello L, Lucangioli S (2010) J Liq Chromatogr Rel Technol 33:1666–1678
Gomes P, Wingert NR, Paim CS, Schapoval EES, Steppe M (2010) J AOAC Int 93:1829–1835
Gowramma B, Rajan S, Muralidharan S, Meyyanathan SN, Suresh B (2010) Int J ChemTech Res 2:676–680
Gumustas M, Ozkan S (2010) Anal Bioanal Chem 397:189–203
Gumustas M, Şanlı S, Şanlı N, Ozkan SA (2010) Talanta 82:1528–1537
Guzik L, Mrozik W, Kamysz W (2010) Croat Chem Acta 83:371–377
Haque T, Talukder MU, Laila S, Fatema K (2010) Pak J Pharm Sci 23:379–383
Jain D, Kachave RN, Bhadane RN (2010) J Liq Chromatogr Rel Technol 33:786–792
Joshi SJ, Karbhari PA, Bhoir SI, Bindu KS, Das C (2010) J Pharm Biomed Anal 52:362–371
Karra UM, Yarkala S (2010) E-J Chem 7:569–577
Kollipara S, Bende G, Saha RN (2010) Indian J Pharm Sci 72:465–470
Kowalczuk D, Pietraś R, Paw B, Czerkies A (2010) Pol J Environ Stud 19:587–591
Kul D, Dogan-Topal B, Kutucu T, Uslu B, Ozkan SA (2010) J AOAC Int 93:882–890
Kul D, Gumustas M, Uslu B, Ozkan SA (2010) Talanta 82:286–295
Lakshmi KS, Rajesh T (2010) J Chil Chem Soc 55:250–252
Londhe S, Kaul N, Agrawal H, Mahadik K (2010) Acta Chromatogr 22:539–548
Malenović A, Jančic-Stojanović B, Ivanović D, Medenica M (2010) J Liq Chromatogr Rel Technol 33:536–547
Manassra A, Khamis M, el-Dakiky M, Abdel-Qader Z, Al-Rimawi F (2010) J Pharm Biomed Anal 51:991–993
Marrubini G, Castillo BE, Mendoza, Massolini G (2010) J Sep Sci 33:803–816
Msagati TAM (2010) Bull Chem Soc Ethiopia 24:175–184
Mustafa G, Azeem A, Ahmad FJ, Khan ZI, Shakeel F, Talegaonkar S (2010) J Chilean Chem Soc 55:184–188
Naguib IA, Abdelkawy M (2010) Eur J Med Chem 45:3719–3725
Pachauri S, Paliwal S, Srinivas KS, Singh Y, Jain V (2010) J Pharm Sci Res 2:459–464
Pasha K, Ali A, Bana S, Humair S (2010) Int J Pharm Pharm Sci 2:46–47
Patro SK, Kanungo SK, Patro VJ, Choudhury NSK (2010) E-J Chem 7:246–252
Prasanthi NL, Rama Rao N (2010) Int J Pharm Pharm Sci 2:120–122
Praveenkumar Reddy B, Boopathy D, Mathew B, Prakash M, Perumal P (2010) Int J ChemTech Res 2:50-53
Ramadan NK, Mohamed HM, Moustafa AA (2010) Anal Lett 43:570–581
Rao KS, Jena N, Rao MEB (2010) J Young Pharm 2:183–189
Semreen MH, Aboul-Enein HY (2010) J Liq Chromatogr Rel Technol 33:720–729
Sharma R, Pancholi S (2010) Acta Pharmaceutica 60:13–24
Sharma S, Sharma MC, Chaturvedi SC (2010) Optoelectro Adv Mater Rapid Commun 4:427–430
Suneetha A, Sundarb S (2010) J Chin Chem Soc 57:1067–1070
Suneetha D, Lakshmana Rao A (2010) Rasayan J Chem 3:117–121
Vaidya VV, Singh GR, Choukekar MP, Kekare MB (2010) E-J Chem 7:260–264
Yang YJ, Song DM, Jiang WM, Xiang BR (2010) Anal Lett 43:373–380
Dorival-García N, Zafra-Gómez A, Navalón A, Vílchez JL (2012) J Chromatogr A 1253:1–10
Venkataro P, Kumar MN, Kumar MR (2012) Sci Pharm 80:965–976
Nageswari A, Reddy KVSRK, Mukkanti K (2012) J Pharm Biomed Anal 66:109–115
Rane SS, Ajameri A, Mody R, Padmaja P (2012) J Pharm Anal 2:136–142
Rane SS, Ajameri A, Mody R, Padmaja P (2012) J Pharm Anal 2:160–165
Heaton J, Gray N, Cowan DA, Plumb RS, Legido-Quigley C, Smith NW (2012) J Chromatogr A 1228:329–337
Sun J, Chen P (2012) J Pharm Biomed Anal 61:142–149
Deconinck E, Verlinde K, Courselle P, De Beer JO (2012) J Pharm Biomed Anal 59:38–43
Douša M, Gibala P, Rádl S, Klecán O, Mandelová Z, Břicháč J, Pekárek T (2012) J Pharm Biomed Anal 58:1–6
Nalwade SU, Reddy VR, Rao DD, Morisetti NK (2012) J Pharm Biomed Anal 57:109–114
Toro-Funes N, Odriozola-Serrano I, Bosch-Fusté J, Latorre-Moratalla ML, Veciana-Nogués MT, Izquierdo-Pulido M, Vidal-Carou MC (2012) Food Chem 135:2832–2838
Dias ALS, Rozet E, Chataigné G, Oliveira AC, Rabelo CAS, Hubert P, Rogez H, Quetin-Leclercq J (2012) J Chromatogr B 907:108–116
Shikanga EA, Kamatou GPP, Chen W, Combrinck S, Viljoen AM (2012) S Afr J Bot 82:99–107
Padullés A, Colom H, Armendariz Y, Cerezo G, Caldes A, Pou L, Torras J, Grinyó JM, Lloberas N (2012) Clin Biochem 45:309–314
Rao PV, Sanjeeva Reddy CK, Kumar MR, Rao DD (2012) J Liq Chromatogr Rel Technol 35:2322–2332
Thakkar R, Saravaia H, Ambasana M, Shah A (2012) J Liq Chromatogr Rel Technol 35:2125–2133
Raj S, Kumari KS, Rao AN, Reddy IU, Raju MN (2012) J Liq Chromatogr Rel Technol 35:1011–1026
Raju TS, Kalyanaraman L, Reddy VV, Swamy PY (2012) J Liq Chromatogr Rel Technol 35:896–911
Chen J-Z, Chou G-X, Yang L, Bligh SWA, Wang Z-T (2012) J Liq Chromatogr Rel Technol 35:788–797
Reddy IU, Rao PN, Reddy VR, Satyanarayana KVV (2012) J Liq Chromatogr Rel Technol 35:688–699
Bindu KH, Dhekale NH, Suryanarayana MV, Anjaneyulu Y (2012) J Liq Chromatogr Rel Technol 35:533–546
Saini D, Baboota S, Ali M, Patel H, Jain P, Neerumulla S, Ali J (2012) J Liq Chromatogr Rel Technol 35:162–173
Naga Malleswararao CS, Suryanaryana MV, Krishna K, Mukkanti K (2012) J Liq Chromatogr Rel Technol 35:2511–2523
Sanches-Silva A, Ribeiro T, Albuquerque TG, Paseiro P, Sendón R, de Quirós AB, López-Cervantes J, Sánchez-Machado DI, Soto Valdez H, Angulo I, Aurrekoetxea GP, Costa HS (2012) Biomed Chromatogr 27:757–764
Valente A, Bronze MR, Bicho M, Duarte R, Costa HS (2012) J Sep Sci 35:3427–3433
Sanches-Silva A, Ribeiro T, Albuquerque TG, Paseiro P, Sendón R, de Quirós AB, López-Cervantes J, Sánchez-Machado DI, Valdez HS, Angulo I, Aurrekoetxea GP, Costa HS (2012) J Sep Sci 35:633–640
Seshadri RK, Raghavaraju TV, Kumar YR, Babu BS, Venkatasubbaiah B (2012) Chakravarthy IE (2012) J Liq Chromatogr Rel Technol. doi:10(1080/10826076):720327
Satheesh B, Sree Ganesh KK, Saravanan D (2012) J Liq Chromatogr Rel Technol. doi:10(1080/10826076):692143
Raj S, Kumari KS, Krishnaiah C, Rao AN (2012) J Liq Chromatogr Rel Technol. doi:10.1080/10826076.2012.678460
Malati V, Raghupatireddy A, Mukkanti K, Suryanarayana MV (2012) J Liq Chromatogr Rel Technol. doi: 10.1080/10826076.2011.644052
Shaikh IM, Tan K-B, Chiu GNC (2012) J Liq Chromatogr Rel Technol. doi:10.1080/10826076.2012.678456
Murthy MV, Krishnaiah C, Kumar R, Mukkanti K (2012) J Liq Chromatogr Rel Technol. doi:10.1080/10826076.2012.678027
Antunes MV, Poeta J, Ribeiro JP, Sprinz E, Linden R (2011) J Braz Chem Soc 22:134–141
Avula B, Wang YH, Rumalla CS, Ali Z, Smillie TJ, Khan IA (2011) J Pharm Biomed Anal 56:895–903
Bhavsar H, Rohini N, Raman B (2011) Indian Drugs 48:42–48
Chen J, Li M, Yan X, Wu E, Zhu H, Lee KJ, Chu VM, Zhan L, Lee W, Kang JS (2011) J Chromatogr B: Anal Tech Biomed Life Sci 879:2669–2672
Chen J, Yang Y, Shi YP (2011) Biomed Chromatogr 25:1045–1053
Davadra PM, Mepal VV, Jain MR, Joshi CG, Bapodra AH (2011) Anal Methods 3:198–204
Fracassetti D, Lawrence N, Tredoux AGJ, Tirelli A, Nieuwoudt HH, Du Toit WJ (2011) Food Chem 128:1136–1142
Ghosh C, Upadhayay A, Singh A, Bahadur S, Jain P, Chakraborty BS (2011) J Liq Chromatogr Rel Technol 34:2326–2338
Grabowski T, Jaroszewski JJ, Świerczewska A, Sawicka R, Maślanka T, Markiewicz W, Ziółkowski H (2011) Biomed Chromatogr 25:1159–1167
Hasan S, Chander P, Ali J, Baboota S, Ali M (2011) Drug Test Anal 3:187–190
He L, Yang L, Xiong A, Zhao S, Wang Z, Hu Z (2011) Anal Sci 27:433–438
Karunakaran K, Navaneethan G, Elango KP (2011) Trop J Pharm Res 10:655–661
Krishnaiah C, Vishnu Murthy M, Kumar R, Mukkanti K (2011) J Pharm Biomed Anal 54:667–673
Liu J, Ma H, Zhu M, Wang H, Zhang T (2011) Chin J Chromatogr (Se Pu) 29:1005–1009
Liu YL, Li DM, Feng L, Yuan H (2011) Yaoxue Xuebao 46:581–585
Liu YL, Li DM, Yuan H, Zhang M, Feng L (2011) Chin Pharm J 46:1753–1755
Nalwade S, Reddy VR, Rao DD, Rao IK (2011) Sci Pharm 79:69–84
Patel P, Sahu K, Karthikeyan C, Hari Narayana Moorthy NS, Trivedi P (2011) Lat Am J Pharm 30:985–990
Patel P, Sahu K, Karthikeyan C, Moorthy NSHN, Trivedi P (2011) Lat Am J Pharm 30:667
Pathan SA, Jain GK, Zaidi SMA, Akhter S, Vohora D, Chander P, Kole PL, Ahmad FJ, Khar RK (2011) Biomed Chromatogr 25:613–620
Qu CH, Li XL, Zhang L, Xi CX, Wang GM, Li NB, Luo HQ (2011) Chromatographia 73:243–249
Rajput AP, Sonanis MC (2011) Int J Pharm Pharm Sci 3:156–160
Ram V, Kher G, Dubal K, Dodiya B, Joshi H (2011) Saudi Pharm J 19:159–164
Rao DD, Sait SS, Mukkanti K (2011) J Chromatogr Sci 49:281–286
Reddy GVR, Reddy BV, Haque SW, Gautam HD, Kumar P, Kumar AP, Park JH (2011) Quim Nova 34:250–255
Sahu K, Karthikeyan C, Moorthy NSHN, Trivedi P (2011) Curr Pharm Anal 7:182–188
Satheesh B, Pulluru SK, Nitin K, Saravanan D (2011) J Liq Chromatogr Rel Technol 34:1885–1890
Shan CX, Li W, Wen HM, Wang XZ, Bai YT, Bian HM (2011) Chin Pharm Bull 27:709–712
Srinivasan V, Sivaramakrishnan H, Karthikeyan B, Balaji TS, Vijayabaskar S (2011) J Liq Chromatogr Rel Technol 34:1631–1644
Thakkar RS, Saravaia HT, Ambasana MA, Kaila HO, Shah AK (2011) Indian J Pharm Sci 73:439–443
Trivedi RK, Patel MC (2011) Sci Pharm 79:97–111
Trivedi RK, Patel MC (2011) E-J Chem 8:167–179
Trivedi RK, Patel MC, Jadhav SB (2011) Sci Pharm 79:525–543
Trivedi RK, Patel MC, Kharkar AR (2011) E-J Chem 8:131–148
Vuppala PK, Boddu SP, Furr EB, McCurdy CR, Avery BA (2011) Chromatographia 74:703–710
Warsi MH, Chaurasiya A, Jain GK, Pathan SA, Chander P, Singh AK, Talegaonkar S, Ahmad FJ, Khar RK (2011) Curr Pharm Anal 7:189–194
Yanamandra R, Chaudhary A, Bandaru SR, Sastry CSP, Patro B, Murthy YLN, Ramaiah PA (2011) Int J PharmTech Res 3:1198–1207
Zhang Y, Huang X, Xie Y, Wang Y, Qiu X, Fan R, Ren P, Liu Z, Zhou H (2011) J Med Plants Res 5:1955–1961
Gikas E, Bazoti FN, Fanourgiakis P, Perivolioti E, Roussidis A, Skoutelis A, Tsarbopoulos A (2010) Biomed Chromatogr 24:522–527
Gikas E, Bazoti FN, Fanourgiakis P, Perivolioti E, Roussidis A, Skoutelis A, Tsarbopoulos A (2010) J Pharm Biomed Anal 51:901–906
Gu Y, Qian D, Duan JA, Wang Z, Guo J, Tang Y, Guo S (2010) J Sep Sci 33:1004–1009
Guo D, Xu LY, Pang LF, Tan ZR, Han Y, Yang H, Zhou G, Chen Y, Ouyang DS, Zhou HH (2010) Chromatographia 72:747–752
Gupta H, Aqil M, Khar RK, Ali A, Chander P (2010) J Chromatogr Sci 48:484–490
Gupta H, Aqil M, Khar RK, Ali A, Sharma A, Chander P (2010) J Chromatogr Sci 48:1–6
Jain DK, Kumar AM, Jain D (2010) Indian J Pharm Educ Res 44:295–300
Kiss B, Bogdan C, Pop A, Loghin F (2010) J Liq Chromatogr Rel Technol 33:1381–1392
Kong W, Jin C, Liu W, Xiao X, Zhao Y, Li Z, Zhang P, Li X (2010) Food Chem 120:1193–1200
Lee SM, Lee HB, Lee CG (2010) Food Chem 123:955–958
Nováková L, Spáčil Z, Seifrtová M, Opletal L, Solich P (2010) Talanta 80:1970–1979
Rao DD, Sait SS, Reddy AM, Chakole D, Reddy YR, Mukkanti K (2010) J Chromatogr Sci 48:819–824
Rao DD, Satyanarayana NV, Malleswara Reddy A, Sait SS, Chakole D, Mukkanti K (2010) J Pharm Biomed Anal 51:736–742
Saini PK, Jain CL, Singh RM, Mathur SC, Singh GN (2010) Indian J Pharm Sci 72:494–497
Seshadri RK, Desai MM, Raghavaraju TV, Krishnan D, Rao DV, Chakravarthy IE (2010) Sci Pharm 78:821–834
Tang F, Cai G, Yuan B, Zhang Z (2010) Zhongguo Zhongyao Zazhi 35:2874–2876
Tylová T, Olšovská J, Novák P, Flieger M (2010) Chemosphere 78:353–359
Wang X, Zheng H, Zhu Z, Wei Y, Chen L (2010) J Pharm Sci 99:4746–4752
Yang GL, Yang LW, Li YX, Cao H, Zhou WL, Fang ZJ, Zhou HB, Mo JL, Xiao SX, Lin HR (2010) J Chromatogr Sci 48:18–21
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Published in the topical collection New Developments for the Sensitive and Validated Drug Analysis Using Chromatographic Methods with guest editor Sibel A. Ozkan.
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Gumustas, M., Kurbanoglu, S., Uslu, B. et al. UPLC versus HPLC on Drug Analysis: Advantageous, Applications and Their Validation Parameters. Chromatographia 76, 1365–1427 (2013). https://doi.org/10.1007/s10337-013-2477-8
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DOI: https://doi.org/10.1007/s10337-013-2477-8