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Chromatographia

, 73:941 | Cite as

Models for Liquid–Liquid Partition in the System Ethylene Glycol–Organic Solvent and Their Use for Estimating Descriptors for Organic Compounds

  • Thushara Karunasekara
  • Colin F. PooleEmail author
Original

Abstract

Partition coefficients for varied compounds were determined for the ethylene glycol–organic solvent biphasic partition system where the organic solvent is n-heptane, 1,2-dichloroethane or isopentyl ether. These partition coefficient databases are analyzed using the solvation parameter model facilitating a quantitative comparison of the ethylene glycol-based partition systems with other totally organic partition systems. Ethylene glycol is a cohesive solvent, reasonably dipolar/polarizable, strongly hydrogen-bond basic, and moderately hydrogen-bond acidic. Ethylene glycol–organic solvent systems offer a complementary approach to other totally organic biphasic partition systems for sample preparation and descriptor measurements of compounds virtually insoluble in water.

Keywords

Liquid–liquid partition Solvation parameter model Totally organic biphasic systems Ethylene glycol 

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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  1. 1.Department of Chemistry, Rm 181 ChemistryWayne State UniversityDetroitUSA

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