, Volume 73, Issue 1–2, pp 25–31 | Cite as

SPE of Tanshinones from Salvia miltiorrhiza Bunge by using Imprinted Functionalized Ionic Liquid-Modified Silica

  • Minglei Tian
  • Kyung Ho RowEmail author


Ionic liquid-modified silica, with functional groups based on imidazole as the cation, was obtained. A molecular imprinting technique was introduced to form the order of functional groups. The selectivity of the obtained ionic liquid-modified silica was successfully used as a special imprinted sorbent in the solid-phase extraction to isolate cryptotanshinone, tanshinone I and tanshinone IIA from Salvia miltiorrhiza Bunge. Several washing and elution solvents with different polarities were evaluated. The ionic liquid-modified silica as the sorbent exhibited a higher selectivity than blank ionic liquid-modified silica, traditional silica and C18 cartridges. A quantitative analysis was conducted by liquid chromatography with a C18 column and methanol/water (75:25, v/v, containing 0.5% acetic acid) as the mobile phase. A good linearity was obtained from 0.5 × 10−4 to 0.1 mg mL−1 (r 2  > 0.99) with relative standard deviations that were less than 4.6%.


Column liquid chromatography Solid-phase extraction Molecular imprinted ionic liquid-modified silica Tanshinones Salvia miltiorrhiza Bunge 



This research was supported by the Basic Science Research Program through the National Research Foundation (NRF) of Korea funded by the Ministry of Education, Science and Technology (2010-0015731).


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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  1. 1.Department of Chemical EngineeringInha UniversityIncheonKorea

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