Ionic Liquid-Based Ultrasound-Assisted Extraction of Chlorogenic Acid from Lonicera japonica Thunb
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Hydrophilic ionic liquid of [BMIM][BF4] was successfully applied for the ultrasound-assisted extraction (UAE) of hydrophilic chlorogenic acid from Lonicera japonica Thunb. To explore this extraction procedure, the corresponding extraction parameters including the sample size, [BMIM][BF4] concentration, pH, extraction temperature, ultrasonic power and extraction time were investigated. The results revealed that the [BMIM][BF4]-based UAE efficiency of chlorogenic acid was higher than that of the ethanol-based UAE and the traditional refluent ethanol extraction. And the study on the method reliability further confirmed that the [BMIM][BF4]-based UAE is suitable for the effective extraction of chlorogenic acid from honeysuckle.