, Volume 73, Issue 1–2, pp 129–133 | Cite as

Ionic Liquid-Based Ultrasound-Assisted Extraction of Chlorogenic Acid from Lonicera japonica Thunb

  • Lijin Zhang
  • Jinfu Liu
  • Pingping Zhang
  • Shijie Yan
  • Xinyi He
  • Fang Chen
Full Short Communication


Hydrophilic ionic liquid of [BMIM][BF4] was successfully applied for the ultrasound-assisted extraction (UAE) of hydrophilic chlorogenic acid from Lonicera japonica Thunb. To explore this extraction procedure, the corresponding extraction parameters including the sample size, [BMIM][BF4] concentration, pH, extraction temperature, ultrasonic power and extraction time were investigated. The results revealed that the [BMIM][BF4]-based UAE efficiency of chlorogenic acid was higher than that of the ethanol-based UAE and the traditional refluent ethanol extraction. And the study on the method reliability further confirmed that the [BMIM][BF4]-based UAE is suitable for the effective extraction of chlorogenic acid from honeysuckle.


Column liquid chromatography Ionic liquid Ultrasound-assisted extraction Chlorogenic acid Lonicera japonica Thunb 


  1. 1.
    China Pharmacopoeia Committee (2005) Pharmacopoeia of the People’s Republic of China, First Division, 2005 ed., China Chemical Industry Press, Beijing, 152Google Scholar
  2. 2.
    Zhang B, Yang RY, Liu CZ (2008) Sep Purif Technol 62:480–483CrossRefGoogle Scholar
  3. 3.
    Xiang ZN, Ning ZX (2008) Food Sci Technol 41:1189–1203Google Scholar
  4. 4.
    Zhang B, Yang RY, Zhao Y, Liu CZ (2008) J Chromatogr B 867:253–258CrossRefGoogle Scholar
  5. 5.
    Wang ZL, Wang JH, Sun YS, Li SB, Wang HZ (2008) Sep Purif Technol 63:721–724CrossRefGoogle Scholar
  6. 6.
    Hu FL, Deng CH, Liu Y, Zhang XM (2009) Talanta 77:1299–1303CrossRefGoogle Scholar
  7. 7.
    Niu JG, Qiu HD, Li J, Liu X, Jiang SX (2009) Chromatographia 69:1093–1096CrossRefGoogle Scholar
  8. 8.
    Sun XQ, Peng B, Ji Y, Chen J, Li DQ (2008) Sep Purif Technol 63:61–68CrossRefGoogle Scholar
  9. 9.
    Zhou QX, Bai HH, Xie GH, Xiao JP (2008) J Chromatogr A 1177:43–49CrossRefGoogle Scholar
  10. 10.
    Fan J, Fan YC, Pei YC, Wu K, Wang JJ, Fan MH (2008) Sep Purif Technol 61:324–331CrossRefGoogle Scholar
  11. 11.
    Du FY, Xiao XH, Luo XJ, Li GK (2009) Talanta 78:1177–1184CrossRefGoogle Scholar
  12. 12.
    Du FY, Xiao XH, Li GK (2007) J Chromatogr A 1140:56–62CrossRefGoogle Scholar
  13. 13.
    Cao XJ, Ye XM, Lu YB, Yu Y, Mo WM (2009) Anal Chim Acta 640:47–51CrossRefGoogle Scholar
  14. 14.
    Wang LJ, Weller CL (2006) Trends Food Sci Technol 17:300–312CrossRefGoogle Scholar
  15. 15.
    Li SQ, Cai S, Hu W, Chen H, Liu HL (2009) Spectrochim Acta Part B 64:666–671CrossRefGoogle Scholar
  16. 16.
    Gao R, Zheng Q, Gong T, Fu Y, Deng L, Zhang ZR (2007) J Pharm Biomed Anal 43:335–340CrossRefGoogle Scholar
  17. 17.
    Yan SK, Luo GA, Wang YM, Cheng YY (2006) J Pharm Biomed Anal 40:889–895CrossRefGoogle Scholar
  18. 18.
    Li ZB, Huang DN, Tang ZX, Deng CH, Zhang XM (2010) Talanta 82:1181–1185CrossRefGoogle Scholar
  19. 19.
    Zhang J, Chen M, Ju WZ, Liu SJ, Xu MJ, Chu JH, Wu T (2010) J Pharm Biomed Anal 51:685–690CrossRefGoogle Scholar
  20. 20.
    Yu YY, Zhang W, Cao SW (2007) Chin J Anal Chem 35:1726–1730CrossRefGoogle Scholar
  21. 21.
    Serpone N, Colarusso P (1994) Res Chem Intermed 20:635–679CrossRefGoogle Scholar
  22. 22.
    Lu YB, Ma WY, Hu RL, Dai XJ, Pan YJ (2008) J Chromatogr A 120:42–46CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Lijin Zhang
    • 1
    • 2
  • Jinfu Liu
    • 2
  • Pingping Zhang
    • 2
  • Shijie Yan
    • 2
  • Xinyi He
    • 2
  • Fang Chen
    • 1
  1. 1.College of Food Science and Nutritional EngineeringChina Agricultural UniversityBeijingChina
  2. 2.Department of Food ScienceTianjin Agricultural UniversityTianjinChina

Personalised recommendations