Direct cerebral and cardiac 17O-MRI at 3 Tesla: initial results at natural abundance
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To establish direct 17O-magnetic resonance imaging (MRI) for metabolic imaging at a clinical field strength of 3 T.
An experimental setup including a surface coil and transmit/receive switch was constructed. Natural abundance in vivo brain images of a volunteer were acquired with a radial three-dimensional (3D) sequence in the visual cortex and in the heart with electrocardiogram (ECG)-gating.
In the brain, a signal-to-noise ratio of 36 was found at a nominal resolution of (5.6 mm)3, and a transverse relaxation time of T2* = (1.9 ± 0.2) ms was obtained. In the heart 17O images were acquired with a temporal resolution of 200 ms.
Cerebral and cardiac 17O-MRI at natural abundance is feasible at 3 T.
KeywordsOxygen-17 Metabolic imaging Ultra-short echo time imaging X-nuclear MRI
The authors thank Manuela Rösler and Reiner Umathum from the German Cancer Research Center (DKFZ) for help with the RxTx switch and the preamplifier, Waldemar Schimpf and Thomas Günter from the workshop at the neuro-center of the University Medical Center Freiburg for assistance with the construction of the setup, and Vladimir Jellus and Peter Speier from Siemens Healthcare for providing the basic UTE pulse sequence code.
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