Reproducibility of subregional trabecular bone micro-architectural measures derived from 7-Tesla magnetic resonance images

  • Gregory ChangEmail author
  • Ligong Wang
  • Guoyuan Liang
  • James S. Babb
  • Punam K. Saha
  • Ravinder R. Regatte
Short Communication


High-resolution magnetic resonance imaging (MRI) of trabecular bone combined with quantitative image analysis represents a powerful technique to gain insight into trabecular bone micro-architectural derangements in osteoporosis and osteoarthritis. The increased signal-to-noise ratio of ultra high-field MR (≥7 Tesla) permits images to be obtained with higher resolution and/or decreased scan time compared to scanning at 1.5/3T. In this small feasibility study, we show high measurement precision for subregional trabecular bone micro-architectural analysis performed on 7T knee MR images. The results provide further support for the use of trabecular bone measures as biomarkers in clinical studies of bone disorders.


Ultra high field 7 Tesla MRI Trabecular bone Micro-architecture Knee 


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Copyright information

© ESMRMB 2011

Authors and Affiliations

  • Gregory Chang
    • 1
    Email author
  • Ligong Wang
    • 1
  • Guoyuan Liang
    • 2
  • James S. Babb
    • 1
  • Punam K. Saha
    • 2
  • Ravinder R. Regatte
    • 1
  1. 1.Center for Biomedical Imaging, Department of RadiologyNew YorkUSA
  2. 2.Departments of Electrical and Computer Engineering and Radiology3414 Seamans Center for the Engineering Arts and Sciences, The University of IowaIowa CityUSA

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