Skip to main content
SpringerLink
Log in

Reproducibility of subregional trabecular bone micro-architectural measures derived from 7-Tesla magnetic resonance images

  • Short Communication
  • Published:
Magnetic Resonance Materials in Physics, Biology and Medicine Aims and scope Submit manuscript

Abstract

High-resolution magnetic resonance imaging (MRI) of trabecular bone combined with quantitative image analysis represents a powerful technique to gain insight into trabecular bone micro-architectural derangements in osteoporosis and osteoarthritis. The increased signal-to-noise ratio of ultra high-field MR (≥7 Tesla) permits images to be obtained with higher resolution and/or decreased scan time compared to scanning at 1.5/3T. In this small feasibility study, we show high measurement precision for subregional trabecular bone micro-architectural analysis performed on 7T knee MR images. The results provide further support for the use of trabecular bone measures as biomarkers in clinical studies of bone disorders.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Majumdar S (2002) Magnetic resonance imaging of trabecular bone structure. Top Magn Reson Imaging 13: 323–334

    Article  PubMed  Google Scholar 

  2. Wehrli FW (2007) Structural and functional assessment of trabecular and cortical bone by micro magnetic resonance imaging. J Magn Reson Imaging 25: 390–409

    Article  PubMed  Google Scholar 

  3. Blumenkrantz G, Lindsey CT, Dunn TC et al (2004) A pilot, two-year longitudinal study of the interrelationship between trabecular bone and articular cartilage in the osteoarthritic knee. Osteoarthritis Cartil 12: 997–1005

    Article  Google Scholar 

  4. Lindsey CT, Narasimhan A, Adolfo JM et al (2004) Magnetic resonance evaluation of the interrelationship between articular cartilage and trabecular bone of the osteoarthritic knee. Osteoarthritis Cartil 12: 86–96

    Article  CAS  Google Scholar 

  5. Newitt DC, van Rietbergen B, Majumdar S (2002) Processing and analysis of in vivo high-resolution MR images of trabecular bone for longitudinal studies: reproducibility of structural measures and micro-finite element analysis derived mechanical properties. Osteoporos Int 13: 278–287

    Article  PubMed  CAS  Google Scholar 

  6. Gomberg BR, Wehrli FW, Vasilic B et al (2004) Reproducibility and error sources of micro-MRI-based trabecular bone structural parameters of the distal radius and tibia. Bone 35: 266–276

    Article  PubMed  CAS  Google Scholar 

  7. Wald MJ, Magland JF, Rajapakse CS, Wehrli FW (2010) Structural and mechanical parameters of trabecular bone estimated from in vivo high-resolution magnetic resonance images at 3 Tesla field strength. J Magn Reson Imaging 31: 1157–1168

    Article  PubMed  Google Scholar 

  8. Maes F, Collignon A, Vandermeulen D, Marchal G, Suetens P (1997) Multimodality image registration by maximization of mutual information. IEEE Trans Med Imaging 16(2): 187–198

    Article  PubMed  CAS  Google Scholar 

  9. Saha PK, Wehrli FW (2004) Measurement of trabecular bone thickness in the limited resolution regime of in vivo MRI by fuzzy distance transform. IEEE Trans Med Imaging 23: 53–62

    Article  PubMed  Google Scholar 

  10. Saha PK, Gomberg BR, Wehrli FW (2000) Three-dimensional digital topological characterization of cancellous bone architecture. Int J Imaging Syst Technol 2000 11: 81–90

    Article  Google Scholar 

  11. Krug R, Carballido-Gamio J, Banerjee S et al (2007) In vivo bone and cartilage MRI using full-balanced steady-state free-precession at 7 Tesla. Magn Reson Med 58: 1294–1298

    Article  PubMed  Google Scholar 

  12. Banerjee S, Krug R, Carballido-Gamio et al (2008) Rapid in vivo musculoskeletal MR with parallel imaging at 7T. Magn Reson Med 29: 655–660

    Article  Google Scholar 

  13. Magland J, Rajapakse CS, Wright AC, Acciavatti R, Wehrli FW (2010) 3D fast spin echo with out-of-slab cancellation: a technique for high resolution structural imaging of trabecular bone at 7 Tesla. Magn Reson Med 63: 719–727

    Article  PubMed  Google Scholar 

  14. Chang G, Pakin SK, Schweitzer ME, Saha PK, Regatte RR (2008) Adaptations in trabecular bone microarchitecture in Olympic athletes determined by 7T MRI. J Magn Reson Imaging 27: 1089–1095

    Article  PubMed  Google Scholar 

  15. Chang G, Friedrich KM, Wang L et al (2010) MRI of the wrist at 7 Tesla using an eight-channel array coil combined with parallel imaging: preliminary results. J Magn Reson Imaging 31: 740–746

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Center for Biomedical Imaging, Department of Radiology, 660 First Avenue, 4th Floor, NYU Langone Medical Center, New York, NY, 10016, USA

    Gregory Chang, Ligong Wang, James S. Babb & Ravinder R. Regatte

  2. Departments of Electrical and Computer Engineering and Radiology, 3414 Seamans Center for the Engineering Arts and Sciences, The University of Iowa, Iowa City, IA, 52242, USA

    Guoyuan Liang & Punam K. Saha

Authors
  1. Gregory Chang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ligong Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Guoyuan Liang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. James S. Babb
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Punam K. Saha
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Ravinder R. Regatte
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Gregory Chang.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chang, G., Wang, L., Liang, G. et al. Reproducibility of subregional trabecular bone micro-architectural measures derived from 7-Tesla magnetic resonance images. Magn Reson Mater Phy 24, 121–125 (2011). https://doi.org/10.1007/s10334-010-0243-6

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10334-010-0243-6

Keywords

Search

Navigation