1H NMR relaxation times of skeletal muscle metabolites at 3 T
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This study reports proton relaxation times of water and metabolites in soleus and tibialis anterior muscles of young healthy volunteers at 3 T. The results are in agreement with data reported for 1.5 and 4 T, showing a steady increase of spin-lattice relaxation times of water, creatine and lipids with B 0 and no effect of B 0 on spin–spin relaxation. Comparison between muscles revealed a longer spin–spin relaxation time of water in soleus than in tibialis anterior muscle (31±1 ms vs. 28±1 ms, p<0.05). These data can be applied to relaxation correction for the absolute quantification of skeletal muscle metabolite concentrations and further sequence optimization.
KeywordsNuclear magnetic resonance spectroscopy Proton Relaxation times Skeletal muscle
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This study was supported by the Austrian Science Foundation (P-13213-MOB and P-15656 to M.R.; and P-15202-B02 to E.M.).