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1H NMR relaxation times of skeletal muscle metabolites at 3 T

  • M. KrššákEmail author
  • M. Roden
  • V. Mlynárik
  • M. Meyerspeer
  • E. Moser
Article

Abstract

This study reports proton relaxation times of water and metabolites in soleus and tibialis anterior muscles of young healthy volunteers at 3 T. The results are in agreement with data reported for 1.5 and 4 T, showing a steady increase of spin-lattice relaxation times of water, creatine and lipids with B 0 and no effect of B 0 on spin–spin relaxation. Comparison between muscles revealed a longer spin–spin relaxation time of water in soleus than in tibialis anterior muscle (31±1 ms vs. 28±1 ms, p<0.05). These data can be applied to relaxation correction for the absolute quantification of skeletal muscle metabolite concentrations and further sequence optimization.

Keywords

Nuclear magnetic resonance spectroscopy Proton Relaxation times Skeletal muscle 

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Notes

Acknowledgments.

This study was supported by the Austrian Science Foundation (P-13213-MOB and P-15656 to M.R.; and P-15202-B02 to E.M.).

Copyright information

© ESMRMB 2004

Authors and Affiliations

  • M. Krššák
    • 1
    • 2
    Email author
  • M. Roden
    • 1
  • V. Mlynárik
    • 3
  • M. Meyerspeer
    • 2
    • 4
  • E. Moser
    • 3
    • 4
  1. 1.Division of Endocrinology and MetabolismDepartment of Internal MedicineViennaAustria
  2. 2.MR-Center of ExcellenceMedical University of ViennaViennaAustria
  3. 3.Department of RadiodiagnosticsMedical University of ViennaViennaAustria
  4. 4.Department of Medical PhysicsMedical University of ViennaViennaAustria

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