Long-term follow-up of patients with acute myocarditis by magnetic resonance imaging

  • Anja Wagner
  • Jeanette Schulz-Menger
  • Rainer Dietz
  • Matthias G. FriedrichEmail author
Research article


Magnetic resonance imaging (MRI) reveals cardiac signal intensity changes in patients with acute myocarditis; however, the natural history of these changes and their relationship to individual outcomes are unknown. The relationship of MRI findings to long-term outcome was studied by serial MRI studies in 16 patients with acute myocarditis who were followed for 30±4 (SE) months. Myocardial contrast enhancement was monitored using contrast-enhanced T1-weighted fast spin-echo images. Left ventricular ejection fraction was measured with gradient-echo sequences. Clinical symptoms were scored. The results were compared to a control group of 26 age-matched, healthy volunteers. Myocardial contrast enhancement, which was markedly increased in the early course of the disease, decreased at 4 weeks and remained within the normal range in most patients after 30 months. Contrast enhancement 4 weeks after onset of symptoms was predictive for the functional and clinical long-term outcome.

Contrast-enhanced MRI may be a useful, noninvasive tool for long-term follow-up of patients with acute myocarditis. Furthermore, relatively early MRI findings may predict longer-term outcomes.


Myocarditis Magnetic resonance imaging Prognosis Follow-up 



We are indebted to Professor Friedrich C. Luft, M.D., for a thorough review of the manuscript and his helpful comments.


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Copyright information

© ESMRMB 2003

Authors and Affiliations

  • Anja Wagner
    • 1
  • Jeanette Schulz-Menger
    • 1
  • Rainer Dietz
    • 1
  • Matthias G. Friedrich
    • 1
    Email author
  1. 1.Franz-Volhard-Klinik, Working group 'Cardiac Magnetic Resonance'Charité Campus Buch, Humboldt UniversityBerlinGermany

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