The Chinese-German Journal of Clinical Oncology

, Volume 10, Issue 11, pp 621–625 | Cite as

The pooled analysis of efficacy and safety profiles of bevacizumab in Chinese cancer patients

  • Huijuan Qiu
  • Wenzhuo He
  • Guifang Guo
  • Xuxian Chen
  • Fang Wang
  • Feifei Zhou
  • Chenxi Yin
  • Liangping Xia
Article

Abstract

Objective

The aim of this study was to investigate the efficacy and safety profiles of bevacizumab, the commonly used monoclonal antibody and its safety profiles were challenging, based on Chinese cancer patients.

Methods

All the papers studied on Chinese cancer patients treated by bevacizumab were found in both databases of Chinese journal database for fulltext and PubMed were collected. The commonly used efficacy index such as disease control rate (CR + PR + SD) and response rate (CR + PR) were analyzed, and the bevacizumab related side effects were analyzed too.

Results

(1) There were ten original papers contained total 199 patients who were the candidates to analyze the safety profiles, and 115 patients with colorectal cancer in five papers who were candidates to analyze the efficacy. (2) Nine in ten papers set the dose of bevacizumab in 2.5 mg/kg/week — 5 mg/kg/week, and the biweekly was the standard chemotherapy interval. (3) The disease control rate and response rate in Chinese colorectal cancer patients were 85% (95% CI: 79%–92%) and 61% (95% CI: 52%–70%), respectively. (4) The side effects related to bevacizumab were rare and most of them were grades 1–2, and only one case with grade 4 bleeding was recorded and only two cases with discontinuation of bevacizumab since hemoplysis. Also, the grades 3–4 side effects related cytotoxic agents were not common.

Conclusion

This study summarized the data of Chinese cancer patients treated by bevacizumab-contained regimens, and it showed that the monoclonal antibody was effective and safe for Chinese patients as the West patients.

Key words

Chinese patient cancer bevacizumab efficacy side effects 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Nalluri SR, Chu D, Keresztes R, et al. Risk of venous thromboembolism with the angiogenesis inhibitor bevacizumab in cancer patients: a meta-analysis. JAMA, 2008, 300: 2277–2285.PubMedCrossRefGoogle Scholar
  2. 2.
    Scappaticci FA, Skillings JR, Holden SN, et al. Arterial thromboembolic events in patients with metastatic carcinoma treated with chemotherapy and bevacizumab. J Natl Cancer Inst, 2007, 99: 1232–1239.PubMedCrossRefGoogle Scholar
  3. 3.
    Gordon CR, Rojavin Y, Patel M, et al. A review on bevacizumab and surgical wound healing: an important warning to all surgeons. Ann Plast Surg, 2009, 62: 707–709.PubMedCrossRefGoogle Scholar
  4. 4.
    Tsai C, Griesinger F, Laskin J, et al. Low incidence of grade 3 bleeding events and low discontinuation rates associated with first-line bevacizumab (Bev) in patients with advanced NSCLC: data from the SAiL (MO19390) study. Eur J Cancer, 2009, 7(2 Suppl): 557–558.Google Scholar
  5. 5.
    Leighl NB, Bennouna J, Yi J, et al. Bleeding events in bevacizumabtreated cancer patients who received full-dose anticoagulation and remained on study. Br J Cancer, 2011, 104: 413–418.PubMedCrossRefGoogle Scholar
  6. 6.
    Hapani S, Chu D, Wu S. Risk of gastrointestinal perforation in patients with cancer treated with bevacizumab: a meta-analysis. Lancet Oncol, 2009, 10: 559–568.PubMedCrossRefGoogle Scholar
  7. 7.
    Zhu X, Wu S, Dahut WL, et al. Risks of proteinuria and hypertension with bevacizumab, an antibody against vascular endothelial growth factor: systematic review and meta-analysis. Am J Kidney Dis, 2007, 49: 186–193.PubMedCrossRefGoogle Scholar
  8. 8.
    Xia LP, Guo GF, Qiu HJ, et al. Efficacy and safety profiles of cetuximab in Chinese patients with colorectal cancer. Chinese-German J Clin Oncol, 2009, 8: 526–530.CrossRefGoogle Scholar
  9. 9.
    Thatcher N, Chang A, Parikh P, et al. Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer). Lancet, 2005, 366: 1527–1537.PubMedCrossRefGoogle Scholar
  10. 10.
    Chang GC, Tsai CM, Chen KC, et al. Predictive factors of gefitinib antitumor activity in East Asian advanced non-small cell lung cancer patients. J Thorac Oncol, 2006, 1: 520–525.PubMedCrossRefGoogle Scholar
  11. 11.
    Haller D, Cassidy J, Clarke S, et al. Tolerability of fluoropyrimidines appears to differ by region. J Clin Oncol, 2006, 24(June 20 Suppl): 16S. Abstract 3514.Google Scholar
  12. 12.
    Micieli JA, Micieli A, Smith AF. Identifying systemic safety signals following intravitreal bevacizumab: systematic review of the literature and the Canadian Adverse Drug Reaction Database. Can J Ophthalmol, 2010, 45: 231–238.PubMedCrossRefGoogle Scholar
  13. 13.
    Li SM, Zhang R, Li HJ, et al. The clinical observation of 18 patients with recurrent ovarian carcinoma treated with bevacizumab combined with chemotherapy. Chin J Clinicians (Electr Edit) (Chinese), 2010, 4: 322–325.Google Scholar
  14. 14.
    Li BJ, Wu XF, Zhu RX. Lobaplatin tegafur combined with bevacizumab in treatment of advanced colorectal cancer — a clinical research. J Huaihai Med (Chinese), 2010, 28: 315–316.Google Scholar
  15. 15.
    Wu XN, Zhao YB, Wu JY, et al. Efficacy and safety of bevacizumab plus capecitabine for metastatic colorectal cancer. Acta Acad Med Sin (Chinese), 2010, 32: 417–420.Google Scholar
  16. 16.
    Xie JM, Xie YL, Chen JZ, et al. Effect of bevacizumab combined with FOLFOX4 on advanced colorectal cancer. Chin Trop Med (Chinese), 2010, 10: 1393–1394.Google Scholar
  17. 17.
    Shi YY, Wang FL. Clinical curative effect of bevacizumab combined PB project to treat cervical carcinoma in middle and late stage. Chin Healthcare Front (Chinese), 2009, 4: 104–105.Google Scholar
  18. 18.
    Wu W, Xu LY, Liu Z, et al. Acceptable safety of bevacizumab therapy in combination with chemotherapy in patients with advanced lung cancer. Chin J Lung Cancer (Chinese), 2009, 12: 231–235.Google Scholar
  19. 19.
    Lin JG, Luo Y, Shi ZH, et al. Twenty-eight cases report of bevacizuamb combined with mFOLFOX6 in treatment of advanced carcinoma of stomach. Chin J Cancer Prev Treat (Chinese), 2008, 15: 546–547.Google Scholar
  20. 20.
    Zhao L, Zhou JF, Guan M, et al. Five cases with advanced colorectal cancer treated with combination of bevacizumab and chemotherapy. Chin Clin Oncol (Chinese), 2007, 12: 385–387.Google Scholar
  21. 21.
    Li HM, Lu HJ, Feng R, et al. The short-term efficacy of 20 patients with metastatic colorectal cancer treated with bevacizumab. Shangdong Med (Chinese), 2007, 47: 54–55.Google Scholar
  22. 22.
    Chen LX, Zhou Q, Chen YB, et al. Clinical observation of advanced tumor patients treated by avastin combined with chemotherapy. J Basic Clin Oncol (Chinese), 2007, 20: 495–497.Google Scholar
  23. 23.
    Saltz LB, Clarke S, Díaz-Rubio E, et al. Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized phase III study. J Clin Oncol, 2008, 26: 2013–2019.PubMedCrossRefGoogle Scholar
  24. 24.
    Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med, 2004, 350: 2335–2342.PubMedCrossRefGoogle Scholar
  25. 25.
    Giantonio BJ, Catalano PJ, Meropol NJ, et al. Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200. J Clin Oncol, 2007, 25: 1539–1544.PubMedCrossRefGoogle Scholar
  26. 26.
    Van Cutsem E, Rivera F, Berry S, et al. Safety and efficacy of first-line bevacizumab with FOLFOX, XELOX, FOLFIRI and fluoropyrimidines in metastatic colorectal cancer: the BEAT study. Ann Oncol, 2009, 20: 1842–1847.PubMedCrossRefGoogle Scholar
  27. 27.
    Grothey A, Sugrue MM, Purdie DM, et al. Bevacizumab beyond first progression is associated with prolonged overall survival in metastatic colorectal cancer: results from a large observational cohort study (BRiTE). J Clin Oncol, 2008, 26: 5326–5334.PubMedCrossRefGoogle Scholar
  28. 28.
    Hambleton J, Novotny WF, Hurwitz H, et al. Bevacizumab does not increase bleeding in patients with metastatic colorectal cancer receiving concurrent anticoagulation. J Clin Oncol, 2004, 22(July 15 Suppl): Abstr 3528.Google Scholar
  29. 29.
    Crinò L, Dansin E, Garrido P, et al. Safety and efficacy of first-line bevacizumab-based therapy in advanced non-squamous non-smallcell lung cancer (SAiL, MO19390): a phase 4 study. Lancet Oncol, 2010, 11: 733–740.PubMedCrossRefGoogle Scholar
  30. 30.
    Sandler A, Gray R, Perry MC, et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med, 2006, 355: 2542–2550.PubMedCrossRefGoogle Scholar
  31. 31.
    Johnson DH, Fehrenbacher L, Novotny WF, et al. Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer. J Clin Oncol, 2004, 22: 2184–2191.PubMedCrossRefGoogle Scholar
  32. 32.
    Somer RA, Sherman E, Langer CJ. Restrictive eligibility limits access to newer therapies in non-small-cell lung cancer: the implications of Eastern Cooperative Oncology Group 4599. Clin Lung Cancer, 2008, 9: 102–105.PubMedCrossRefGoogle Scholar
  33. 33.
    Besse B, Lasserre SF, Compton P, et al. Bevacizumab safety in patients with central nervous system metastases. Clin Cancer Res, 2010, 16: 269–278.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • Huijuan Qiu
    • 1
    • 2
  • Wenzhuo He
    • 1
    • 2
  • Guifang Guo
    • 1
    • 2
  • Xuxian Chen
    • 1
    • 2
  • Fang Wang
    • 1
    • 2
  • Feifei Zhou
    • 3
  • Chenxi Yin
    • 1
    • 2
  • Liangping Xia
    • 1
    • 2
  1. 1.State Key Laboratory of Oncology in South ChinaSun Yat-sen University Cancer CenterGuangzhouChina
  2. 2.VIP RegionSun Yat-sen University Cancer CenterGuangzhouChina
  3. 3.Tumor CenterThe Foshan First People’s HospitalFoshanChina

Personalised recommendations