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The expression and significance of cyclin B1 and survivin in human non-small cell lung cancer

  • Published:
The Chinese-German Journal of Clinical Oncology

Abstract

Objective

We studied the expression of cyclin B1 and survivin in human non-small cell lung cancer (NSCLC), and the relationship between such expression and clinicopathological features of NSCLC.

Methods

One hundred cases of tissue specimen including NSCLC, neighboring noncancerous tissue and normal lung tissue were collected at random. These specimens were detected by immunohistochemical methods.

Results

The expression of cyclin B1 and survivin showed significant difference (P < 0.01) between NSCLC tissues, proliferating epithelial cells of bronchioles and small bronchi in neighboring noncancerous tissues, and normal lung tissues. Compared with normal lung tissues, there was an overexpression of cyclin B1 and survivin in NSCLC and an enhancing expression of cyclin B1 and survivin in proliferating epithelial cells of bronchioles and small bronchi in neighboring noncancerous tissues. Significantly positive correlation was found between the overexpression of cyclin B1 and that of survivin in 100 NSCLC cases (P < 0.01). The significantly positive correlation was also found between the enhancing expression of cyclin B1 and that of survivin in proliferating epithelial cells of bronchioles and small bronchi in neighboring noncancerous tissues (P < 0.01). No statistical significance was found between the different histological types, the differentiated degree, lymphatic metastasis and the expression of cyclin B1 and survivin (P > 0.05) in NSCLC. Statistical significance was marked between different clinical stages of NSCLC and the expression of cyclin B1 and survivin (P < 0.05).

Conclusion

The overexpression of cyclin B1 and survivin was found in NSCLC. The expression of cyclin B1 and survivin might be up-regulated during an early step of tumorigenesis and during the development of NSCLC. The progression of cell cycle could be efficiently connected with the control of apoptosis by the interrelations between the overexpression of cyclin B1 and that of survivin in NSCLC during the G2/M phase. The overexpression of cyclin B1 and survivin might be used as marker in showing the dividing and proliferating ability, and the inhibiting apoptosis ability (lengthening cell lifespan) of NSCLC. Moreover, the overexpression of cyclin B1 and survivin was associated with the clinic stages of NSCLC.

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Authors and Affiliations

  1. Department of Pathology, The First Affiliated Hospital of Dalian Medical University, Dalian, 116011, China

    Guosheng Li

  2. Department of Endocrinology, Dalian Municipal Central Hospital, Dalian, 116003, China

    Xuhan Liu

  3. Department of Pathology, College of Basic Medical Sciences, China Medical University, Shenyang, 110001, China

    Daorong Zhang

  4. Department of Pathology, Tumor Hospital (Institute) of Liaoning Province, Shenyang, 110042, China

    Dong Liu

  5. Department of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, 116011, China

    Zhiyong Li

Authors
  1. Guosheng Li
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  2. Xuhan Liu
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  3. Daorong Zhang
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  4. Dong Liu
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  5. Zhiyong Li
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Corresponding author

Correspondence to Zhiyong Li.

Additional information

Supported by a grant from the Science and Technology Department of Liaoning Province (No. 2010225034).

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Li, G., Liu, X., Zhang, D. et al. The expression and significance of cyclin B1 and survivin in human non-small cell lung cancer. Chin. -Ger. J. Clin. Oncol. 10, 192–197 (2011). https://doi.org/10.1007/s10330-011-0771-1

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  • DOI: https://doi.org/10.1007/s10330-011-0771-1

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