Prognostic relevance of ALDH1 in breast cancer: a clinicopathological study of 96 cases
The aim of the study was to investigate the expression and clinical significance of aldehyde dehydrogenase 1 (ALDH1) in breast cancer patients.
The expression of ALDH1 protein was examined by immunohistochemical staining in 96 breast cancer tissues. The disease-free survival analysis of patients was evaluated based on the clinical follow-up data.
Expression of ALDH1 protein had significant correlations with ER, PR, and HER2 proteins (P < 0.05), but had no significant correlations with age, tumor size, clinical stage, P- glycoprotein, and lymph node status (P > 0.05). The 2-year disease-free survival rate of ALDH1-positive patients was lower than that of ALDH1-negative patients (P < 0.05). ALDH1-positive patients undergoing chemotherapy and hormonal therapy had lower 2-year disease-free survival rate than ALDH1-negative patients (P < 0.05).
ALDH1 expression might play an important role in drug resistant, and ALDH1 may be used as a prognostic marker.
Key wordsbreast cancer stem cells, aldehyde dehydrogenase 1 (ALDH1) prognosis
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