Prognostic relevance of ALDH1 in breast cancer: a clinicopathological study of 96 cases

  • Pei Yu
  • Ling Zhou
  • Jianfeng Wang
  • Aifang Jiang
  • Ke Li
Article

Abstract

Objective

The aim of the study was to investigate the expression and clinical significance of aldehyde dehydrogenase 1 (ALDH1) in breast cancer patients.

Methods

The expression of ALDH1 protein was examined by immunohistochemical staining in 96 breast cancer tissues. The disease-free survival analysis of patients was evaluated based on the clinical follow-up data.

Results

Expression of ALDH1 protein had significant correlations with ER, PR, and HER2 proteins (P < 0.05), but had no significant correlations with age, tumor size, clinical stage, P- glycoprotein, and lymph node status (P > 0.05). The 2-year disease-free survival rate of ALDH1-positive patients was lower than that of ALDH1-negative patients (P < 0.05). ALDH1-positive patients undergoing chemotherapy and hormonal therapy had lower 2-year disease-free survival rate than ALDH1-negative patients (P < 0.05).

Conclusion

ALDH1 expression might play an important role in drug resistant, and ALDH1 may be used as a prognostic marker.

Key words

breast cancer stem cells, aldehyde dehydrogenase 1 (ALDH1) prognosis 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  • Pei Yu
    • 1
  • Ling Zhou
    • 2
  • Jianfeng Wang
    • 2
  • Aifang Jiang
    • 2
  • Ke Li
    • 1
  1. 1.Department of General SurgeryFirst People’s Hospital of Shanghai Jiaotong UniversityShanghaiChina
  2. 2.Department of PathologyShanghai No. 1 People Branch HospitalShanghaiChina

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