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XIAP expression and its predictive significance of prognosis in stage IIB osteosarcomas

  • Published:
The Chinese-German Journal of Clinical Oncology

Abstract

Objective

To evaluate X-linked inhibitor of apoptosis protein (XIAP) expression in biopsy specimens from the patients with stage IIB osteosarcomas before chemotherapy to study XIAP expression and its predictive significance of prognosis in stage IIB osteosarcomas.

Methods

The expression of XIAP was retrospectively detected by SP immunohistochemistry in 31 cases biopsy specimens from stage IIB osteosarcomas before chemotherapy, and the relationship between XIAP expression and clinicopathologic features of the patients with stage IIB osteosarcomas was analyzed.

Results

The osteosarcoma specimens showed strong cell nucleus immunoreaction of XIAP while normal bone specimens showed weak. High XIAP positive expression independently predicted the patient’s poor outcome and had no relationship with clinicopathologic variables such as age, gender, location, tumor size, rate of tumor necrosis to preoperative chemotherapy, local recurrence (P > 0.05). Significant correlations were found between high XIAP expression and metastasis (P = 0.022), and also between high XIAP expression and final survival (P = 0.011).

Conclusion

XIAP plays an important role in the development of stage IIB osteosarcomas and XIAP expression of biopsy specimens before chemotherapy can be seen as a promising prognostic marker in early predicting the outcome of patients suffering from stage IIB osteosarcomas.

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Authors and Affiliations

  1. Department of Orthopedics, Guangzhou First Municipal People’s Hospital, Guangzhou Medical College, Guangzhou, 510180, China

    Yunfa Yang, Jianwei Wang, Guangming Zhang & Zhonghe Xu

  2. Department of Pathology, Guangzhou First Municipal People’s Hospital, Guangzhou Medical College, Guangzhou, 510180, China

    Hong Du

  3. Department of Surgery, Liwang Hospital, Guangzhou Medical College, Guangzhou, 510180, China

    Pin Huang

Authors
  1. Yunfa Yang
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  2. Hong Du
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  3. Pin Huang
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  4. Jianwei Wang
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  5. Guangming Zhang
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  6. Zhonghe Xu
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Corresponding author

Correspondence to Yunfa Yang.

Additional information

Supported by a grant from the Foundation for Scientific Research of Medical Science of Guangzhou (No. 2006-YB-017).

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Yang, Y., Du, H., Huang, P. et al. XIAP expression and its predictive significance of prognosis in stage IIB osteosarcomas. Chin. -Ger. J. Clin. Oncol. 7, 416–419 (2008). https://doi.org/10.1007/s10330-008-0024-0

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  • DOI: https://doi.org/10.1007/s10330-008-0024-0

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