Neoadjuvant chemotherapy with pingyangmycin can inhibit the amplification and metastasis of laryngeal squamous cell carcinoma
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To evaluate the short-term effects of neoadjuvant chemotherapy with pingyangmycin (PYM) in the treatment of laryngeal squamous cell carcinoma.
24 cases of laryngeal squamous cell carcinoma were treated with PYM before the operation, and the surgeries were undergone within one week after neoadjuvant chemotherapy. PCNA, p53, Bcl-2 and CD44v6 were detected in the specimens of tumor, retreated tumor and normal tissue using immunohistochemical methods.
Apoptosis could be detected more often in specimens with tumor and retreated tumor after chemotherapy than that before. The expression of PCNA, p53, Bcl-2 and CD44v6 in tumor tissue after neoadjuvant chemotherapy with PYM was weaker than that before the chemotherapy. There was significant difference in the positive ratio of PCNA, p53, Bcl-2 and CD44v6 between retreated tumor and tumor.
After neoadjuvant chemotherapy with PYM, a large number of tumor cells died. The amplification and metastasis of tumor were suppressed by neoadjuvant chemotherapy with PYM.
Key wordslaryngeal squamous cell carcinoma PYM neoadjuvant chemotherapy PCNA p53 Bcl-2 CD44v6
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