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Double-blinded, Controlled, Randomized Study of Dihydrocodeine Tartrate vs Codeine Phosphate in Treating Cancer Pain

  • WANG Jiejun 
  • ZOU Jianjun 
  • GAO Yong 
  • XU Qing 
  • CAO Chuanwu 
  • QIAN Jianxin 
  • XU Defeng 
  • PAN Huijun 
Original Paper

Abstract

Objective: To compare the effects and adverse reactions of dihydrocodeine tartrate and codeine phosphate in treating moderate cancer pain. Methods: Sixty-nine cases of cancer patients with moderate pain were treated with dihydrocodeine tartrate or codeine phosphate respectively by double-blind, controlled randomized methods and the effects and adverse reactions were observed. Results: After administration of dihydrocodeine tartrate or codeine phosphate, in treatment group or control group, the total effective rate was 86.6% and 93.6%, and common adverse symptoms included constipation (31.3%/12.9%), nausea (18.8%/19.7%), gastric trouble (18.8%/19.7%), skin pruritus (12.5%/10%), vomit (9.3% and 6.5%) with the difference being not significant. Conclusion: The effects of dihydrocodeine tartrate in treating moderate cancer pain are similar to codeine phosphate. Both them can be used to treat moderate cancer pain.

dihydrocodeine tartrate codeine phosphate cancer pain 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2005

Authors and Affiliations

  • WANG Jiejun 
    • 1
  • ZOU Jianjun 
    • 1
  • GAO Yong 
    • 1
  • XU Qing 
    • 1
  • CAO Chuanwu 
    • 1
  • QIAN Jianxin 
    • 1
  • XU Defeng 
    • 2
  • PAN Huijun 
    • 3
  1. 1.Department of Medical OncologyChangzheng HospitalShanghai
  2. 2.Department of Medical OncologyNo. 10 People’s HospitalShanghai
  3. 3.Department of Medical OncologyNorth HospitalShanghai

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