Environmental Chemistry Letters

, Volume 17, Issue 4, pp 1881–1888 | Cite as

The metribuzin herbicide in polycaprolactone nanocapsules shows less plant chromosome aberration than non-encapsulated metribuzin

  • Marjan DiyanatEmail author
  • Hamid Saeidian
Original Paper


The excessive use of the metribuzin herbicide is contaminating groundwater and damaging non-target plants and organisms. There is therefore a need for safer formulations of the herbicide. Here we encapsulated metribuzin by interfacial deposition of the pre-formed polymer. Results show that the encapsulation efficiency of metribuzin reached 83.2%. Nanocapsules remained stable in the suspension without any aggregation or decomposition. Nanocapsules containing metribuzin induced less chromosome aberration and higher mitotic index values than the pure metribuzin. We conclude that herbicide encapsulation in polycaprolactone nanocapsules is safer for food and the environment.


Genotoxicity Metribuzin Nanoformulation Polydispersity index Polycaprolactone nanocapsules 



The authors thank Iran National Science Foundation (INSF) for financial support (Grant No. 95834912).

Compliance with ethical standards

Conflicts of interest

All authors declare that they have no conflict of interest.

Supplementary material

10311_2019_912_MOESM1_ESM.docx (1.2 mb)
Supplementary material 1 (DOCX 1252 kb)


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of Agricultural Science and Food Industries, Science and Research BranchIslamic Azad UniversityTehranIran
  2. 2.Department of SciencePayame Noor University (PNU)TehranIran

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