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Environmental Chemistry Letters

, Volume 16, Issue 4, pp 1415–1421 | Cite as

Synthesis of carboxylic dithiocarbamic anhydride and substituted thiourea derivatives in water

  • Najmedin AziziEmail author
  • Masuomeh Alipour
Original Paper
  • 96 Downloads

Abstract

The use of water as a solvent has sometimes benefits such as improving reactivities and selectivities, simplifying work-up procedures, and environmentally benign. Many carboxylic dithiocarbamic anhydride products are valuable building blocks in heterocycles and natural products. Here we present a simple one-pot synthesis of carboxylic dithiocarbamic anhydride by condensation of amines, carbon disulfide, acyl halide, or acetic anhydride in water. We obtained a variety of biologically important acyl dithiocarbamate derivatives in 82–93% yields in 10–30 min. This procedure can be used for the synthesis of thioureas from dithiocarbamates. Here, the sequential, one-pot three-component reaction of amines, carbon disulfide, and isothiocyanates provides unsymmetrical substituted thioureas in 81–91% yields.

Keywords

Dithiocarbamic anhydride Dithiocarbamate Isothiocyanate Thiourea Water chemistry 

Notes

Acknowledgements

Financial support of this work by the Chemistry and Chemical Engineering Research Center of Iran is gratefully appreciated.

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Chemistry and Chemical Engineering Research Center of IranTehranIran

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