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Nanoemulsion ingredients and components

  • Nandita DasguptaEmail author
  • Shivendu RanjanEmail author
  • Mansi Gandhi
Review
  • 97 Downloads

Abstract

Food nanotechnology involves the study of interactions between oil, water, surfactants and various ingredients such as active compounds, gelling agents, preservatives, chelating agents, flavors and colorants. In particular, the molecular structure and functions of nanoemulsions control the stability and organoleptic properties of nano-food products. For example, the overuse of surfactants to stabilize nanoemulsions may lead to toxicity of final food products. This review discusses methodical, logical and judicial selection of oils, surfactants, co-surfactants, active ingredients and other components. Ingredients for developing food-grade nanoemulsions are described.

Keywords

Food-grade nanoemulsion Ingredients Components Systematic selection Interaction 

References

  1. Ahmadi Lakalayeh G, Faridi-Majidi R, Saber R et al (2012) Investigating the parameters affecting the stability of superparamagnetic iron oxide-loaded nanoemulsion using artificial neural networks. AAPS PharmSciTech 13:1386–1395.  https://doi.org/10.1208/s12249-012-9864-6 CrossRefGoogle Scholar
  2. Akhavan S, Assadpour E, Katouzian I, Mahdi S (2018) Trends in food science & technology lipid nano scale cargos for the protection and delivery of food bioactive ingredients and nutraceuticals. Trends Food Sci Technol 74:132–146.  https://doi.org/10.1016/j.tifs.2018.02.001 CrossRefGoogle Scholar
  3. Al-Edresi S, Baie S (2009) Formulation and stability of whitening VCO-in-water nano-cream. Int J Pharm 373:174–178.  https://doi.org/10.1016/j.ijpharm.2009.02.011 CrossRefGoogle Scholar
  4. Alfaro L, Hayes D, Boeneke C et al (2015) Physical properties of a frozen yogurt fortified with a nano-emulsion containing purple rice bran oil. LWT Food Sci Technol 62:1184–1191.  https://doi.org/10.1016/j.lwt.2015.01.055 CrossRefGoogle Scholar
  5. Al-Nemrawi NK, Dave RH (2016) Formulation and characterization of acetaminophen nanoparticles in orally disintegrating films. Drug Deliv 23:540–549CrossRefGoogle Scholar
  6. Anandharamakrishnan C (2014) Techniques for nanoencapsulation of food ingredients. Food Sci Nutr.  https://doi.org/10.1007/978-1-4614-9387-7 CrossRefGoogle Scholar
  7. Andrew XC (2013) Nanoemulsion composition containing vitamin KGoogle Scholar
  8. Artiga-artigas M, Guerra-rosas MI, Morales-castro J, Salvia-trujillo L (2018) Food Hydrocolloids Influence of essential oils and pectin on nanoemulsion formulation: a ternary phase experimental approach. Food Hydrocoll 81:209–219.  https://doi.org/10.1016/j.foodhyd.2018.03.001 CrossRefGoogle Scholar
  9. Arunkumar R, Prashanth KVH, Baskaran V (2013) Promising interaction between nanoencapsulated lutein with low molecular weight chitosan: characterization and bioavailability of lutein in vitro and in vivo. Food Chem 141:327–337CrossRefGoogle Scholar
  10. Augustin MA, Sanguansri L (2014) Challenges and solutions to incorporation of nutraceuticals in foods. Annu Rev Food Sci Technol 6:1–15.  https://doi.org/10.1146/annurev-food-022814-015507 CrossRefGoogle Scholar
  11. Ax K, Mayer-Miebach E, Link B et al (2003) Stability of lycopene in oil-in-water emulsions. Eng Life Sci 3:199–201.  https://doi.org/10.1002/elsc.200390028 CrossRefGoogle Scholar
  12. Azizi M, Kierulf A, Connie Lee M, Abbaspourrad A (2018) Improvement of physicochemical properties of encapsulated echium oil using nanostructured lipid carriers. Food Chem 246:448–456.  https://doi.org/10.1016/j.foodchem.2017.12.009 CrossRefGoogle Scholar
  13. Baker Jr JR, Hemmila MR, Wang SC et al (2016) Nanoemulsion therapeutic compositions and methods of using the same. PCT International ApplicationsGoogle Scholar
  14. Baldissera MD, Da Silva AS, Oliveira CB et al (2013) Trypanocidal activity of the essential oils in their conventional and nanoemulsion forms: in vitro tests. Exp Parasitol 134:356–361.  https://doi.org/10.1016/j.exppara.2013.03.035 CrossRefGoogle Scholar
  15. Bernardi DS, Pereira TA, Maciel NR et al (2011) Formation and stability of oil-in-water nanoemulsions containing rice bran oil: in vitro and in vivo assessments. J Nanobiotechnol 9:44.  https://doi.org/10.1186/1477-3155-9-44 CrossRefGoogle Scholar
  16. Bhargava K, Conti DS, da Rocha SRP, Zhang Y (2015) Application of an oregano oil nanoemulsion to the control of foodborne bacteria on fresh lettuce. Food Microbiol 47:69–73CrossRefGoogle Scholar
  17. Bonferoni MC, Riva F, Invernizzi A et al (2018) Alpha tocopherol loaded chitosan oleate nanoemulsions for wound healing. Evaluation on cell lines and ex vivo human biopsies, and stabilization in spray dried Trojan microparticles. Eur J Pharm Biopharm 123:31–41.  https://doi.org/10.1016/j.ejpb.2017.11.008 CrossRefGoogle Scholar
  18. Boon CS, Xu Z, Yue X et al (2008) Factors affecting lycopene oxidation in oil-in-water emulsions. J Agric Food Chem 56:1408–1414.  https://doi.org/10.1021/jf072929+ CrossRefGoogle Scholar
  19. Bou R, Boon C, Kweku A et al (2011) Effect of different antioxidants on lycopene degradation in oil-in-water emulsions. Eur J Lipid Sci Technol 113:724–729.  https://doi.org/10.1002/ejlt.201000524 CrossRefGoogle Scholar
  20. Budilarto ES, Kamal-Eldin A (2015) The supramolecular chemistry of lipid oxidation and antioxidation in bulk oils. Eur J Lipid Sci Technol 117:1095–1137.  https://doi.org/10.1002/ejlt.201400200 CrossRefGoogle Scholar
  21. Campardelli R, Reverchon E (2015) α-Tocopherol nanosuspensions produced using a supercritical assisted process. J Food Eng 149:131–136.  https://doi.org/10.1016/j.jfoodeng.2014.10.015 CrossRefGoogle Scholar
  22. Carrillo-inungaray ML, Trejo-ramirez JA, Reyes-munguia A, Carranza-alvarez C (2018) Use of nanoparticles in the food industry: advances and perspectives. Impact Nanosci Food Ind.  https://doi.org/10.1016/b978-0-12-811441-4/00015-7 CrossRefGoogle Scholar
  23. Chaari M, Theochari I, Papadimitriou V et al (2018) Encapsulation of carotenoids extracted from halophilic Archaea in oil-in-water (O/W) micro- and nano-emulsions. Colloids Surf B Biointerfaces 161:219–227.  https://doi.org/10.1016/j.colsurfb.2017.10.042 CrossRefGoogle Scholar
  24. Chen H, Guan Y, Zhong Q (2015) Microemulsions based on a sunflower lecithin-tween 20 blend have high capacity for dissolving peppermint oil and stabilizing coenzyme Q10. J Agric Food Chem 63:983–989.  https://doi.org/10.1021/jf504146t CrossRefGoogle Scholar
  25. Cheng K, Niu Y, Zheng XC et al (2016) A comparison of natural (D-α-tocopherol) and synthetic (DL-α-tocopherol Acetate) vitamin E supplementation on the growth performance, meat quality and oxidative status of broilers. Asian-Australas J Anim Sci 29:681CrossRefGoogle Scholar
  26. Dalgleish DG (2011) On the structural models of bovine casein micelles—review and possible improvements. Soft Matter 7:2265CrossRefGoogle Scholar
  27. Dasgupta N, Ranjan S (2018) Ingredients and components of nanoemulsions. In: An introduction to food grade nanoemulsions. Springer, Singapore, pp 63–82.  https://doi.org/10.1007/978-981-10-6986-4_4
  28. Dasgupta N, Ranjan S, Mundekkad D et al (2015) Nanotechnology in agro-food: from field to plate. Food Res Int 69:381–400CrossRefGoogle Scholar
  29. Dasgupta N, Ranjan S, Chakraborty AR et al (2016a) Nanoagriculture and water quality management. Nanosci Food Agric 1(1):1–18.  https://doi.org/10.1007/978-3-319-39303-2_1 CrossRefGoogle Scholar
  30. Dasgupta N, Ranjan S, Mundra S et al (2016b) Fabrication of food grade vitamin E nanoemulsion by low energy approach, characterization and its application. Int J Food Prop 19:700–708.  https://doi.org/10.1080/10942912.2015.1042587 CrossRefGoogle Scholar
  31. Delaveau J, Minost A, Fessi H et al (2015) Long-acting nanoencapsulated coumarin arthropod repellent formulations and methods of use thereofGoogle Scholar
  32. Dickinson E (2010) Food emulsions and foams: stabilization by particles. Curr Opin Colloid Interface Sci 15:40–49CrossRefGoogle Scholar
  33. Duarte JL, Amado JRR, Oliveira AEMFM et al (2015) Evaluation of larvicidal activity of a nanoemulsion of Rosmarinus officinalis essential oil. Rev Bras Farmacogn.  https://doi.org/10.1016/j.bjp.2015.02.010 CrossRefGoogle Scholar
  34. Filipović J, Pezo L, Filipović V et al (2015) The effects of ω − 3 fatty acids and inulin addition to spelt pasta quality. LWT Food Sci Technol 63:43–51CrossRefGoogle Scholar
  35. Fuchs-Godec R, Zerjav G (2015) Corrosion resistance of high-level-hydrophobic layers in combination with Vitamin E-(α-tocopherol) as green inhibitor. Corros Sci 97:7–16CrossRefGoogle Scholar
  36. Gadkari PV, Balaraman M (2015) Extraction of catechins from decaffeinated green tea for development of nanoemulsion using palm oil and sunflower oil based lipid carrier systems. J Food Eng 147:14–23.  https://doi.org/10.1016/j.jfoodeng.2014.09.027 CrossRefGoogle Scholar
  37. Ghosh V, Mukherjee A, Chandrasekaran N (2013) Formulation and characterization of plant Essential oil based nanoemulsion: evaluation of its larvicidal activity against aedes aegypti. Asian J Chem 25:18–20CrossRefGoogle Scholar
  38. Gonnet M, Lethuaut L, Boury F (2010) New trends in encapsulation of liposoluble vitamins. J Control Release 146:276–290CrossRefGoogle Scholar
  39. Gupta A, Eral HB, Hatton TA, Doyle PS (2016) Nanoemulsions: formation, properties and applications. Soft Matter 12:2826–2841.  https://doi.org/10.1039/C5SM02958A CrossRefGoogle Scholar
  40. Homayoonfal M, Khodaiyan F, Mousavi SM (2014) Optimization of walnut oil nanoemulsions prepared using ultrasonic emulsification: a response surface method. J Dispers Sci Technol 35:685–694CrossRefGoogle Scholar
  41. Hormann K, Zimmer A (2016) Drug delivery and drug targeting with parenteral lipid nanoemulsions—a review. J Control Release 223:85–98CrossRefGoogle Scholar
  42. Hwang TL, Fang CL, Chen CH, Fang JY (2009) Permeation enhancer-containing water-in-oil nanoemulsions as carriers for intravesical cisplatin delivery. Pharm Res 26:2314–2323.  https://doi.org/10.1007/s11095-009-9947-6 CrossRefGoogle Scholar
  43. Jain A, Ranjan S, Dasgupta N, Ramalingam C (2018) Nanomaterials in food and agriculture: an overview on their safety concerns and regulatory issues. Crit Rev Food Sci Nutr 58(2):297–317.  https://doi.org/10.1080/10408398.2016.1160363 CrossRefGoogle Scholar
  44. Jeirani Z, Mohamed Jan B, Si Ali B et al (2013) Formulation, optimization and application of triglyceride microemulsion in enhanced oil recovery. Ind Crops Prod 43:6–14CrossRefGoogle Scholar
  45. Jiang SP, He SN, Li YL et al (2013) Preparation and characteristics of lipid nanoemulsion formulations loaded with doxorubicin. Int J Nanomed 8:3141–3150.  https://doi.org/10.2147/IJN.S47708 CrossRefGoogle Scholar
  46. Jintapatanakit A, Hasan HM, Junyaprasert VB (2018a) Center of excellence in innovation drug delivery and nanomedicine, faculty of pharmacy. J Drug Deliv Sci Technol.  https://doi.org/10.1016/j.jddst.2017.12.018 CrossRefGoogle Scholar
  47. Jintapatanakit A, Hasan HM, Junyaprasert VB (2018b) Vegetable oil-based nanoemulsions containing curcuminoids: formation optimization by phase inversion temperature method. J Drug Deliv Sci Technol.  https://doi.org/10.1016/j.jddst.2017.12.018 CrossRefGoogle Scholar
  48. Jo Y-J, Kwon Y-J (2014) Characterization of β-carotene nanoemulsions prepared by microfluidization technique. Food Sci Biotechnol 23:107–113CrossRefGoogle Scholar
  49. Joe MM, Chauhan PS, Bradeeba K et al (2012) Influence of sunflower oil based nanoemulsion (AUSN-4) on the shelf life and quality of Indo-Pacific king mackerel (Scomberomorus guttatus) steaks stored at 20 °C. Food Control 23:564–570.  https://doi.org/10.1016/j.foodcont.2011.08.032 CrossRefGoogle Scholar
  50. Journal B, Nikolovski BG, Sovilj MN (2016) How to formulate a stable and monodisperse water-in-oil nanoemulsion containing pumpkin seed oil: the use of multiobjective. Braz J Chem Eng 33:919–931CrossRefGoogle Scholar
  51. Jufri M, Azmi N, Shamsuddin AF (2012) Effects of intravenous palm oil-based lipid nanoemulsion on fat metabolism in rabbits. Asian Pac J Trop Dis.  https://doi.org/10.1016/s2222-1808(12)60297- CrossRefGoogle Scholar
  52. Katouzian I, Faridi A, Mahdi S, Akhavan S (2017) Trends in Food Science & Technology Formulation and application of a new generation of lipid nano-carriers for the food bioactive ingredients. Trends Food Sci Technol 68:14–25.  https://doi.org/10.1016/j.tifs.2017.07.017 CrossRefGoogle Scholar
  53. Katzer T, Chaves P, Bernardi A et al (2014) Castor oil and mineral oil nanoemulsion: development and compatibility with a soft contact lens. Pharm Dev Technol 19:232–237.  https://doi.org/10.3109/10837450.2013.769569 CrossRefGoogle Scholar
  54. Khalid N, Kobayashi I, Neves MA et al (2013a) Preparation and characterization of water-in-oil emulsions loaded with high concentration of l-ascorbic acid. LWT Food Sci Technol 51:448–454.  https://doi.org/10.1016/j.lwt.2012.11.020 CrossRefGoogle Scholar
  55. Khalid N, Kobayashi I, Neves MA et al (2013b) Preparation and characterization of water-in-oil-in-water emulsions containing a high concentration of L-ascorbic acid. Biosci Biotechnol Biochem 77:1171–1178.  https://doi.org/10.1271/bbb.120870 CrossRefGoogle Scholar
  56. Kheynoor N, Mohammad S, Hosseini H et al (2018) Encapsulation of vitamin C in a rebaudioside-sweetened model beverage using water in oil in water double emulsions. LWT Food Sci Technol.  https://doi.org/10.1016/j.lwt.2018.05.066 CrossRefGoogle Scholar
  57. Kim DM, Hyun SS, Yun P et al (2012) Identification of an emulsifier and conditions for preparing stable nanoemulsions containing the antioxidant astaxanthin. Int J Cosmet Sci 34:64–73.  https://doi.org/10.1111/j.1468-2494.2011.00682.x CrossRefGoogle Scholar
  58. Kiokias S, Proestos C, Varzakas T (2016) A review of the structure, biosynthesis, absorption of carotenoids-analysis and properties of their common natural extracts. Curr Res Nutr Food Sci J 4:25–37CrossRefGoogle Scholar
  59. Komaiko J, McClements DJ (2015) Food-grade nanoemulsion filled hydrogels formed by spontaneous emulsification and gelation: optical properties, rheology, and stability. Food Hydrocoll 46:67–75.  https://doi.org/10.1016/j.foodhyd.2014.12.031 CrossRefGoogle Scholar
  60. Komaiko J, Sastrosubroto A, McClements DJ (2016) Encapsulation of w-3 fatty acids in nanoemulsion-based delivery systems fabricated from natural emulsifiers: sunflower phospholipids. Food Chem 203:331–339.  https://doi.org/10.1016/j.foodchem.2016.02.080 CrossRefGoogle Scholar
  61. Kumar S, Talegaonkar S, Negi LM, Khan ZI (2012) Design and development of ciclopirox topical nanoemulsion gel for the treatment of subungual onychomycosis. Indian J Pharm Educ Res 46:303–311Google Scholar
  62. Lang G, Buchbauer G (2012) A review on recent research results (2008–2010) on essential oils as antimicrobials and antifungals. A review. Flavour Fragr J 27:13–39CrossRefGoogle Scholar
  63. Li YJ, Li LY, Li JL et al (2015) Effects of dietary supplementation with ferulic acid or vitamin E individually or in combination on meat quality and antioxidant capacity of finishing pigs. Asian Australas J Anim Sci 28:374–381.  https://doi.org/10.5713/ajas.14.0432 CrossRefGoogle Scholar
  64. Liang R, Xu S, Shoemaker CF et al (2012) Physical and antimicrobial properties of peppermint oil nanoemulsions. J Agric Food Chem 60:7548–7555.  https://doi.org/10.1021/jf301129k CrossRefGoogle Scholar
  65. Mayer S, Weiss J, McClements DJ (2013) Behavior of vitamin E acetate delivery systems under simulated gastrointestinal conditions: lipid digestion and bioaccessibility of low-energy nanoemulsions. J Colloid Interface Sci 404:215–222.  https://doi.org/10.1016/j.jcis.2013.04.048 CrossRefGoogle Scholar
  66. McClements DJ (2015) Enhancing nutraceutical bioavailability through food matrix design. Curr Opin Food Sci 4:1–6CrossRefGoogle Scholar
  67. McClements DJ (2016) Recent progress in hydrogel delivery systems for improving nutraceutical bioavailability. Food Hydrocoll 68:238CrossRefGoogle Scholar
  68. Mcclements DJ (2018) Function enhanced delivery of lipophilic bioactives using emulsions: a review of major factors affecting vitamin, nutraceutical, and lipid bioaccessibility. Food Funct.  https://doi.org/10.1039/c7fo01515a CrossRefGoogle Scholar
  69. Mcclements DJ, Jafari SM (2018) General aspects of nanoemulsions and their formulation. Elsevier, AmsterdamCrossRefGoogle Scholar
  70. McClements DJ, Li Y (2010) Structured emulsion-based delivery systems: controlling the digestion and release of lipophilic food components. Adv Colloid Interface Sci 159:213–228.  https://doi.org/10.1016/j.cis.2010.06.010 CrossRefGoogle Scholar
  71. McClements DJ, Decker EA, Park Y, Weiss J (2009) Structural design principles for delivery of bioactive components in nutraceuticals and functional foods. Crit Rev Food Sci Nutr 49:577–606.  https://doi.org/10.1080/10408390902841529 CrossRefGoogle Scholar
  72. McClements DJ, Li F, Xiao H (2015) The nutraceutical bioavailability classification scheme: classifying nutraceuticals according to factors limiting their oral bioavailability. Annu Rev Food Sci Technol 6:299–327CrossRefGoogle Scholar
  73. McClements DJ, Bai L, Chung C (2017) Recent advances in the utilization of natural emulsifiers to form and stabilize emulsions. Annu Rev Food Sci Technol 8:205–236.  https://doi.org/10.1146/annurev-food-030216-030154 CrossRefGoogle Scholar
  74. Mehmood T (2015) Optimization of the canola oil based vitamin E nanoemulsions stabilized by food grade mixed surfactants using response surface methodology. Food Chem 183:1–7.  https://doi.org/10.1016/j.foodchem.2015.03.021 CrossRefGoogle Scholar
  75. Meléndez-Martínez AJ, Mapelli-Brahm P, Benítez-González A, Stinco CM (2015) A comprehensive review on the colorless carotenoids phytoene and phytofluene. Arch Biochem Biophys 572:188–200CrossRefGoogle Scholar
  76. Meng Z, Qi K, Guo Y et al (2018) Effects of thickening agents on the formation and properties of edible oleogels based on hydroxypropyl methyl cellulose. Food Chem 246:137–149CrossRefGoogle Scholar
  77. Mohamed Salama M, Ahmad Mustafa ME (2013) Formulation and evaluation of avocado oil nanoemulsion hydrogels using sucrose ester laureate. Adv Mater Res (Durnten-Zurich, Switzerland) 812:246–249.  https://doi.org/10.4028/www.scientific.net/AMR.812.246 CrossRefGoogle Scholar
  78. Mohammadi A, Jafari SM, Esfanjani AF, Akhavan S (2016) Application of nano-encapsulated olive leaf extract in controlling the oxidative stability of soybean oil. Food Chem 190:513–519.  https://doi.org/10.1016/j.foodchem.2015.05.115 CrossRefGoogle Scholar
  79. Morais DJM, Burgess J (2014) Vitamin E nanoemulsions characterization and analysis. Int J Pharm 465:455–463.  https://doi.org/10.1016/j.ijpharm.2014.02.034 CrossRefGoogle Scholar
  80. Mungure TE, Roohinejad S, Bekhit AE et al (2018) Accept ecrt. Curr Opin Food Sci.  https://doi.org/10.1016/j.cofs.2018.01.011 CrossRefGoogle Scholar
  81. Nguyen MH, Hwang IC, Park HJ (2013) Enhanced photoprotection for photo-labile compounds using double-layer coated corn oil-nanoemulsions with chitosan and lignosulfonate. J Photochem Photobiol B Biol 125:194–201.  https://doi.org/10.1016/j.jphotobiol.2013.06.009 CrossRefGoogle Scholar
  82. Nicolosi RJ, Wilson T (2015) Compositions and methods for making and using nanoemulsions. https://patents.google.com/patent/WO2009121069A2
  83. Noori S, Zeynali F, Almasi H (2018) Antimicrobial and antioxidant efficiency of nanoemulsion-based edible coating containing ginger (Zingiber officinale) essential oil and its effect on safety and quality attributes of chicken breast fillets. Food Control 84:312–320.  https://doi.org/10.1016/j.foodcont.2017.08.015 CrossRefGoogle Scholar
  84. O’Sullivan JJ, Drapala KP, Kelly AL, O’Mahony JA (2018) The use of inline high-shear rotor-stator mixing for preparation of high-solids milk protein-stabilised oil-in-water emulsions with different protein: fat ratios. J Food Eng 222:218–225.  https://doi.org/10.1016/j.jfoodeng.2017.10.015 CrossRefGoogle Scholar
  85. Ofokansi KC, Chukwu KI, Ugwuanyi SI (2009) The use of liquid self-microemulsifying drug delivery systems based on peanut oil/Tween 80 in the delivery of griseofulvin. Drug Dev Ind Pharm 35:185–191.  https://doi.org/10.1080/03639040802244292 CrossRefGoogle Scholar
  86. Ostertag F, Weiss J, McClements DJ (2012) Low-energy formation of edible nanoemulsions: factors influencing droplet size produced by emulsion phase inversion. J Colloid Interface Sci 388:95–102.  https://doi.org/10.1016/j.jcis.2012.07.089 CrossRefGoogle Scholar
  87. Otoni CG, Pontes SFO, Medeiros EAA, Soares NdeFF (2014) Edible films from methylcellulose and nanoemulsions of clove bud (Syzygium aromaticum) and oregano (Origanum vulgare) essential oils as shelf life extenders for sliced bread. J Agric Food Chem 62:5214–5219CrossRefGoogle Scholar
  88. Ozturk B, Argin S, Ozilgen M, McClements DJ (2015) Formation and stabilization of nanoemulsion-based vitamin E delivery systems using natural biopolymers: whey protein isolate and gum arabic. Food Chem.  https://doi.org/10.1016/j.foodchem.2015.05.005 CrossRefGoogle Scholar
  89. Pant M, Dubey S, Patanjali PK et al (2014) Insecticidal activity of eucalyptus oil nanoemulsion with karanja and jatropha aqueous filtrates. Int Biodeterior Biodegrad 91:119–127.  https://doi.org/10.1016/j.ibiod.2013.11.019 CrossRefGoogle Scholar
  90. Pardeike J, Hommoss A, Müller RH (2009) Lipid nanoparticles (SLN, NLC) in cosmetic and pharmaceutical dermal products. Int J Pharm 366:170–184CrossRefGoogle Scholar
  91. Patil A, Bhide S, Bookwala M et al (2017) Mini-review stability of organoleptic agents in pharmaceuticals and cosmetics. AAPS PharmSciTech.  https://doi.org/10.1208/s12249-017-0866-2 CrossRefGoogle Scholar
  92. Piorkowski DT, McClements DJ (2014) Beverage emulsions: recent developments in formulation, production, and applications. Food Hydrocoll 42:5–41.  https://doi.org/10.1016/j.foodhyd.2013.07.009 CrossRefGoogle Scholar
  93. Poonia N, Kharb R, Lather V, Pandita D (2016) Nanostructured lipid carriers: versatile oral delivery vehicle. Futur Sci OA 2:FSO135.  https://doi.org/10.4155/fsoa-2016-0030 CrossRefGoogle Scholar
  94. Prichapan N, Klinkesorn U (2014) Factor affecting the properties of water-in-oil-in-water emulsions for encapsulation of minerals and vitamins. Songklanakarin J Sci Technol 36:651–661Google Scholar
  95. Puri R, Mahajan M, Sahajpal NS et al (2015) Self-nanoemulsifying drug delivery system of docosahexanoic acid: development, in vitro, in vivo characterization. Drug Dev Ind Pharm.  https://doi.org/10.3109/03639045.2015.1107089 CrossRefGoogle Scholar
  96. Rabelo CAS, Taarji N, Khalid N et al (2018) Formulation and characterization of water-in-oil nanoemulsions loaded with açaí berry anthocyanins: insights of degradation kinetics and stability evaluation of anthocyanins and nanoemulsions. Food Res Int.  https://doi.org/10.1016/j.foodres.2018.01.017 CrossRefGoogle Scholar
  97. Ramisetty KA, Pandit AB, Gogate PR (2015) Ultrasound assisted preparation of emulsion of coconut oil in water: understanding the effect of operating parameters and comparison of reactor designs. Chem Eng Process Process Intensif 88:70–77.  https://doi.org/10.1016/j.cep.2014.12.006 CrossRefGoogle Scholar
  98. Ranjan S, Dasgupta N, Chakraborty AR et al (2014) Nanoscience and nanotechnologies in food industries: opportunities and research trends. J Nanoparticle Res 16:1–23.  https://doi.org/10.1007/s11051-014-2464-5 CrossRefGoogle Scholar
  99. Ranjan S, Nandita D, Lichtfouse E (2016a) Nanoscience in food and agriculture 2, 1st edn. Springer, SwitzerlandGoogle Scholar
  100. Ranjan S, Nandita D, Lichtfouse E (2016b) Nanoscience in food and agriculture 1, 1st edn. Springer, SwitzerlandGoogle Scholar
  101. Rao J, McClements DJ (2011) Food-grade microemulsions, nanoemulsions and emulsions: fabrication from sucrose monopalmitate & lemon oil. Food Hydrocoll 25:1413–1423.  https://doi.org/10.1016/j.foodhyd.2011.02.004 CrossRefGoogle Scholar
  102. Rao J, McClements DJ (2012a) Food-grade microemulsions and nanoemulsions: role of oil phase composition on formation and stability. Food Hydrocoll 29:326–334.  https://doi.org/10.1016/j.foodhyd.2012.04.008 CrossRefGoogle Scholar
  103. Rao J, McClements DJ (2012b) Lemon oil solubilization in mixed surfactant solutions: rationalizing microemulsion & nanoemulsion formation. Food Hydrocoll 26:268–276.  https://doi.org/10.1016/j.foodhyd.2011.06.002 CrossRefGoogle Scholar
  104. Ricaurte L, Perea-Flores M de J, Martinez A, Quintanilla-Carvajal MX (2016) Production of high-oleic palm oil nanoemulsions by high-shear homogenization (Microfluidization). Innov Food Sci Emerg Technol.  https://doi.org/10.1016/j.ifset.2016.04.004 CrossRefGoogle Scholar
  105. Ron N, Zimet P, Bargarum J, Livney YD (2010) Beta-lactoglobulin–polysaccharide complexes as nanovehicles for hydrophobic nutraceuticals in non-fat foods and clear beverages. Int Dairy J 20:686–693CrossRefGoogle Scholar
  106. Roy A (2018) Formulation and characterization of betel leaf (Piper betle L.) essential oil based nanoemulsion and its in vitro antibacterial efficacy against selected food pathogens. J Food Process Preserv.  https://doi.org/10.1111/jfpp.13617 CrossRefGoogle Scholar
  107. Rubio-Rodríguez N, Beltrán S, Jaime I et al (2010) Production of omega-3 polyunsaturated fatty acid concentrates: a review. Innov Food Sci Emerg Technol 11:1–12CrossRefGoogle Scholar
  108. Ryckebosch E, Bruneel C, Muylaert K, Foubert I (2012) Microalgae as an alternative source of omega-3 long chain polyunsaturated fatty acids. Lipid Technol 24:128–130.  https://doi.org/10.1002/lite.201200197 CrossRefGoogle Scholar
  109. Saberi AH, Fang Y, McClements DJ (2013) Fabrication of vitamin E-enriched nanoemulsions: factors affecting particle size using spontaneous emulsification. J Colloid Interface Sci 391:95–102.  https://doi.org/10.1016/j.jcis.2012.08.069 CrossRefGoogle Scholar
  110. Sánchez-Salcedo EM, Sendra E, Carbonell-Barrachina ÁA et al (2016) Fatty acids composition of Spanish black (Morus nigra L.) and white (Morus alba L.) mulberries. Food Chem 190:566–571CrossRefGoogle Scholar
  111. Sharma A, Kumar N, Srivastava A et al (2018) Industrial crops & products clove and lemongrass oil based non-ionic nanoemulsion for suppressing the growth of plant pathogenic Fusarium oxysporum f. sp. lycopersici. Ind Crop Prod 123:353–362.  https://doi.org/10.1016/j.indcrop.2018.06.077 CrossRefGoogle Scholar
  112. Smoliga JM, Blanchard O (2014) Enhancing the delivery of resveratrol in humans: if low bioavailability is the problem, what is the solution? Molecules 19:17154–17172CrossRefGoogle Scholar
  113. Sotomayor-Gerding D, Oomah BD, Acevedo F et al (2016) High carotenoid bioaccessibility through linseed oil nanoemulsions with enhanced physical and oxidative stability. Food Chem 199:463–470.  https://doi.org/10.1016/j.foodchem.2015.12.004 CrossRefGoogle Scholar
  114. Stellavato A, Virginia A, Pirozzi A et al (2018) In vitro assessment of nutraceutical compounds and novel nutraceutical formulations in a liver-steatosis-based model. Lipids Health Dis.  https://doi.org/10.1186/s12944-018-0663-2 CrossRefGoogle Scholar
  115. Stounbjerg L, Vestergaard C, Andreasen B, Ipsen R (2017) Beverage clouding agents: review of principles and current manufacturing. Food Rev Int.  https://doi.org/10.1080/87559129.2017.1373286 CrossRefGoogle Scholar
  116. Sugumar S, Nirmala J, Ghosh V et al (2013) Bio-based nanoemulsion formulation, characterization and antibacterial activity against food-borne pathogens. J Basic Microbiol 53:677–685.  https://doi.org/10.1002/jobm.201200060 CrossRefGoogle Scholar
  117. Sugumar S, Ghosh V, Nirmala MJ et al (2014) Ultrasonic emulsification of eucalyptus oil nanoemulsion: antibacterial activity against Staphylococcus aureus and wound healing activity in Wistar rats. Ultrason Sonochem 21:1044–1049.  https://doi.org/10.1016/j.ultsonch.2013.10.021 CrossRefGoogle Scholar
  118. Sugumar S, Mukherjee A, Chandrasekaran N (2015a) Nanoemulsion formation and characterization by spontaneous emulsification: investigation of its antibacterial effects on listeria monocytogenes. Asian J Pharm.  https://doi.org/10.4103/0973-8398.150033 CrossRefGoogle Scholar
  119. Sugumar S, Mukherjee A, Chandrasekaran N (2015b) Eucalyptus oil nanoemulsion-impregnated chitosan film: antibacterial effects against a clinical pathogen, Staphylococcus aureus, in vitro. Int J Nanomed 10:67–75.  https://doi.org/10.2147/IJN.S79982 CrossRefGoogle Scholar
  120. Tabibiazar M, Davaran S, Hashemi M et al (2015) Design and fabrication of a food-grade albumin-stabilized nanoemulsion. Food Hydrocoll 44:220–228CrossRefGoogle Scholar
  121. Tamjidi F, Shahedi M, Varshosaz J, Nasirpour A (2018) Stability of astaxanthin-loaded nanostructured lipid carriers in beverage systems. J Sci Food Agric 98:511CrossRefGoogle Scholar
  122. Teng J, Hu X, Wang M, Tao N (2018) Fabrication of chia (Salvia hispanica L.) seed oil nanoemulsions using different emulsifiers. J Food Process Preserv 42:1–9.  https://doi.org/10.1111/jfpp.13416 CrossRefGoogle Scholar
  123. Topuz OK, Özvural EB, Zhao Q et al (2016) Physical and antimicrobial properties of anise oil loaded nanoemulsions on the survival of foodborne pathogens. Food Chem 203:117–123.  https://doi.org/10.1016/j.foodchem.2016.02.051 CrossRefGoogle Scholar
  124. Uzun S, Kim H, Leal C, Padua GW (2016) Ethanol-induced whey protein gels as carriers for lutein droplets. Food Hydrocoll 61:426–432CrossRefGoogle Scholar
  125. van de Rest O, de Groot C (2014) The impact of omega-3 fatty acids on quality of life. In: Omega-3 fatty acids in brain and neurological health. Elsevier, Amsterdam, pp 81–85Google Scholar
  126. Vijayalakshmi G, Mukherjee A, Chandrasekaran N (2014) Eugenol-loaded antimicrobial nanoemulsion preserves fruit juice against, microbial spoilage. Colloids Surf B Biointerfaces 114:392–397.  https://doi.org/10.1016/j.colsurfb.2013.10.034 CrossRefGoogle Scholar
  127. Vyas TK, Shahiwala A, Amiji MM (2008) Improved oral bioavailability and brain transport of Saquinavir upon administration in novel nanoemulsion formulations. Int J Pharm 347:93–101.  https://doi.org/10.1016/j.ijpharm.2007.06.016 CrossRefGoogle Scholar
  128. Wang Z, Pal R (2014) Enlargement of nanoemulsion region in pseudo-ternary mixing diagrams for a drug delivery system. J Surfactants Deterg 17:49–58CrossRefGoogle Scholar
  129. Yang Y, McClements DJ (2013) Vitamin E bioaccessibility: influence of carrier oil type on digestion and release of emulsified α-tocopherol acetate. Food Chem 141:473–481.  https://doi.org/10.1016/j.foodchem.2013.03.033 CrossRefGoogle Scholar
  130. Yang C, Wu T, Qi Y, Zhang Z (2018) Recent advances in the application of vitamin E TPGS for drug delivery. Theranostics 8:464–485.  https://doi.org/10.7150/thno.22711 CrossRefGoogle Scholar
  131. Yao M, McClements DJ, Xiao H (2015) Improving oral bioavailability of nutraceuticals by engineered nanoparticle-based delivery systems. Curr Opin Food Sci 2:14–19CrossRefGoogle Scholar
  132. Zhang X (2013) Tea tree oil nanoemulsion and its preparation method thereof. Faming Zhuanli ShenqingGoogle Scholar
  133. Zheng N, Gao Y, Ji H et al (2016) Vitamin E derivative-based multifunctional nanoemulsions for overcoming multidrug resistance in cancer. J Drug Target 24:663–669CrossRefGoogle Scholar
  134. Zhou Q, Xu J, Yang S et al (2015) The effect of various antioxidants on the degradation of O/W microemulsions containing esterified astaxanthins from haematococcus pluvialis. J Oleo Sci 64:515CrossRefGoogle Scholar
  135. Ziani K, Fang Y, McClements DJ (2012) Fabrication and stability of colloidal delivery systems for flavor oils: effect of composition and storage conditions. Food Res Int 46:209–216.  https://doi.org/10.1016/j.foodres.2011.12.017 CrossRefGoogle Scholar
  136. Zou L, Liu W, Liu C et al (2015) Utilizing food matrix effects to enhance nutraceutical bioavailability: increase of curcumin bioaccessibility using excipient emulsions. J Agric Food Chem 63:2052–2062.  https://doi.org/10.1021/jf506149f(2018)AcceptedMuspt CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  1. 1.Faculty of Engineering and the Built EnvironmentUniversity of JohannesburgJohannesburgSouth Africa
  2. 2.School of Advanced SciencesVellore Institute of TechnologyVelloreIndia

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