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Environmental Chemistry Letters

, Volume 8, Issue 2, pp 185–191 | Cite as

Stability studies of cholesterol lowering statin drugs in aqueous samples using HPLC and LC–MS

  • Małgorzata Piecha
  • Mohamed Sarakha
  • Polonca Trebše
  • Drago Kočar
Original Paper

Abstract

In this study, stability of statin drugs in different conditions, such as various pH, diverse solvents ratio, presence of UV, and sunlight have been investigated. Results suggest strong dependence of statins upon pH, potential environmental persistence towards sun light, and UV light degradation via singlet excited state obtained by excitation into the ππ* band. In acidic conditions interconversion between lactone and hydroxy acid forms in aqueous solutions at room temperature is retarded, while for the same sun-exposed samples are accelerated. Longer exposures lead to the degradation processes. Statin interconversion in water is much lower than in acetonitrile.

Keywords

Statins Lipid regulators Simvastatin Lovastatin Pravastatin 

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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Małgorzata Piecha
    • 1
  • Mohamed Sarakha
    • 2
  • Polonca Trebše
    • 1
  • Drago Kočar
    • 3
  1. 1.Laboratory for Environmental ResearchUniversity of Nova GoricaNova GoricaSlovenia
  2. 2.Laboratoire de Photochimie Moléculaire et MacromoléculaireUniversité Blaise PascalAubière CedexFrance
  3. 3.Faculty of Chemistry and Chemical TechnologyUniversity of LjubljanaLjubljanaSlovenia

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