Fungal laccases: from structure-activity studies to environmental applications
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Abstract
Laccases are multicopper oxidases mainly secreted by filamentous fungi. Producing radical forms from organic substrates, they are involved in numerous reactions leading to the degradation and polymerization of xenobiotics. Our studies have led to a better knowledge of the structural, catalytic and genetic properties of laccases and allowed to develop a strategy for their evolution through genetic engineering. Here, we show that fungal laccases, wild or engineered, may be potent tools to develop bioremediation processes of soils polluted by organic compounds, and assays to assess the ecotoxicological impact of these pollutants on soil fungi.
Keywords
Fungal laccases Xenobiotics Biotransformation Bioremediation Ecotoxicological risk assessment Genomics ProteomicsNotes
Acknowledgments
The authors thank Annick Lacombe (INRA, Jouy en Josas) for attentive reading of the manuscript.
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