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Zeitschrift für Epileptologie

, Volume 32, Issue 4, pp 339–351 | Cite as

Lebensqualität bei Epilepsie: Ein Überblick zum Forschungsstand – Teil 3: Korrelate und Determinanten von Lebensqualität

  • Michael EndermannEmail author
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Zusammenfassung

Hintergrund

Seit den 1990er-Jahren ist in der Epileptologie Lebensqualität (Quality of Life [QOL]) bzw. gesundheitsbezogene Lebensqualität Gegenstand der klinischen Forschung. Dabei wird in einzelnen Studien meist nicht explizit erläutert, von welchem QOL-Konzept bzw. -Verständnis ausgegangen wird.

Ziele der Arbeit

In einem Überblick sollen die wichtigsten Ergebnisse der Forschung zur QOL bei Epilepsie aufgezeigt werden. In diesem 3. Teil geht es abschließend um den Forschungsschwerpunkt „QOL-Korrelate und Determinanten“, also um Studien, die analysierten, welche Variablen mit QOL assoziiert sind bzw. QOL beeinflussen.

Material und Methoden

Die Archive der einschlägigen Fachzeitschriften Epilepsia, Epilepsy & Behavior sowie Seizure seit Beginn der 1990er-Jahre wurden daraufhin untersucht, ob in Publikationen QOL thematisiert oder QOL-Daten erhoben worden waren. Auf repräsentative Studien wird verwiesen.

Ergebnisse

Bezüglich der QOL-Korrelate und Determinanten ist festzuhalten: Anfallskontrolle und Depressivität haben sich regelhaft als wichtige Determinanten von epilepsiespezifischer QOL erwiesen, wobei klinische Variablen wie Anfallskontrolle weniger QOL-Varianz aufklären als psychosoziale Variablen wie Depressivität.

Schlussfolgerung

Das QOL-Konzept ist nicht als bloßes, auf subjektiver Patienteneinschätzung basierendes Surrogat für das Behandlungsziel Anfallskontrolle zu verstehen. Es verweist vielmehr auf die Notwendigkeit, sich damit zu beschäftigen, ob weitere Krankheitsaspekte bzw. Komorbidität eine Belastung für den Patienten darstellen und ggf. therapeutischer Interventionen bedürfen.

Schlüsselwörter

Lebensqualität-Varianz Anfallskontrolle Depressivität Komorbidität Zusätzliche therapeutische Interventionen 

Quality of life in epilepsy: an overview of the state of research – Part 3: correlates and determinants of quality of life

Abstract

Background

In epileptology the quality of life (QOL) and health-related quality of life (HRQOL) have been the subject of clinical research since the 1990s. Nevertheless, QOL concepts and comprehension are only rarely explained in empirical studies.

Aim

This review summarizes the most important results of QOL research in epilepsy. Part 3 deals finally with the QOL research focus on correlates and determinants. Corresponding studies looked for variables that were associated with QOL or have an impact on QOL.

Material and methods

Beginning with the 1990s, the archives of the relevant specialist journals Epilepsia, Epilepsy & Behavior as well as Seizure were reviewed with respect to QOL concepts and QOL data. Representative studies on QOL in epilepsy are presented.

Results

Research on correlates and determinants of QOL in epilepsy demonstrated that seizure control and depression were regularly shown to be important determinants of QOL in patients with epilepsy. Clinical variables such as seizure control accounted for less QOL variance than psychosocial variables such as depression.

Conclusion

The QOL concept does not merely represent a subjective patient-based surrogate for the treatment goal of seizure control. It refers more to the necessity to look for further stressing epilepsy characteristics or comorbidities and to initiate additional treatment if required.

Keywords

Quality of life variance Seizure control Depression Comorbidity Additional treatment 

Notes

Einhaltung ethischer Richtlinien

Interessenkonflikt

M. Endermann gibt an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine vom Autor durchgeführten Studien an Menschen oder Tieren.

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Copyright information

© Springer Medizin Verlag GmbH, ein Teil von Springer Nature 2018

Authors and Affiliations

  1. 1.Psychologischer Fachdienst Bethel.regionalvon Bodelschwinghsche Stiftungen BethelBielefeldDeutschland

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