Phytothérapie

, Volume 15, Issue 4, pp 203–210 | Cite as

Effet antimicrobien et sur le mal de gorge d’un spray à base d’extraits de sauge et de sureau, d’huile essentielle de menthe poivrée, de miel et de zinc

  • B. Deyra
  • I. Guinobert
  • C. Feuillolay
  • L. Haddioui
  • C. Roques
  • A. Brochot
Phytothérapie
  • 23 Downloads

Résumé

Le mal de gorge est un des motifs de consultation en médecine générale les plus fréquents. Pour le soulager, outre les traitements allopathiques usuels, la prise de produits de phytothérapie peut être envisagée. L’intérêt d’un produit de phytothérapie associant des extraits de sauge et de sureau, de l’huile essentielle de menthe poivrée, du miel et du zinc dans la prise en charge du mal de gorge a été évalué in vitro en mesurant son activité sur les principaux pathogènes impliqués dans les angines (microméthode en milieu liquide) et au cours d’une enquête observationnelle prospective conduite en pharmacie d’officine. Une activité bactéricide a été observée à la fois sur les bactéries à Gram négatif (Branhamella catarrhalis, Fusobacterium nucleatum et Haemophilus influenzae) et à Gram positif (Streptococcus pyogenes) étudiées ainsi qu’une activité antivirale visà-vis du virus para-influenzae de type 3. Cette activité a été maintenue après dilution du produit au 1/64. Les données recueillies au cours de l’étude observationnelle suggèrent que le produit de phytothérapie peut soulager le mal de gorge et les symptômes associés en particulier la sensation de gorge sèche et l’érythème dans un délai de 17 minutes en moyenne après pulvérisation du produit. Tout en éliminant les éventuels pathogènes impliqués, le produit de phytothérapie pourrait donc soulager la douleur et les symptômes associés au mal de gorge. Ces résultats devront être confirmés au cours d’une étude clinique.

Mots clés

Mal de gorge Sauge Sureau Menthe poivrée Zinc Antimicrobien 

Antimicrobial effect and on sore throat symptoms of a spray containing sage and elder extracts, peppermint essential oil, honey and zinc

Abstract

Sore throat is one of the most common reasons for consultation in general medicine. Besides the usual allopathic drugs, phytotherapy can be envisaged for its management. To assess the relevance of a product combining extracts of sage and elder, peppermint essential oil, honey and zinc for the management of sore throat, its effect was evaluated in vitro against the main pathogens involved in sore throat (broth microdilution method) and in a prospective observational study carried out in pharmacies. Bactericidal activity was observed against all Gram-negative (Branhamella catarrhalis, Fusobacterium nucleatum and Haemophilus influenzae) and Gram-positive (Streptococcus pyogenes) bacteria strains; antiviral activity was also tested against type 3 para-influenzae virus. Product activity was maintained at 1:64 dilution ratio. Data collected during the observational study suggest that the product can relieve pain and other symptoms such as dry throat sensation and erythema within 17 minutes on average after spraying. While eliminating possible pathogens involved, the product could relieve pain and symptoms associated with sore throat. These results will have to be confirmed in a clinical trial.

Keywords

Sore throat Sage Elder Peppermint Zinc Antimicrobial 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Références

  1. 1.
    Goetz P (2004) Phytothérapie des laryngites et aphonie. Phytothérapie 2:198–9CrossRefGoogle Scholar
  2. 2.
    Lacroix D, Bontemps F (2012) Rhume, toux et maux de gorge. Le Moniteur des pharmacies 2:1–16Google Scholar
  3. 3.
    Renner B, Mueller CA, Shephard A (2012) Environmental and non-infectious factors in the aetiology of pharyngitis (sore throat). Inflamm Res 61:1041–52CrossRefPubMedPubMedCentralGoogle Scholar
  4. 4.
    Kenealy T (2014) Sore throat. BMJ Clin Evid (Online) 2017:1509Google Scholar
  5. 5.
    Van den Abbeele (2004) Angine et pharyngite de l’enfant et de l’adulte. Rev Prat 54:991–6PubMedGoogle Scholar
  6. 6.
    Halpert P (2013) Maux de gorge. In: Conseil à l’officine: fiches pratiques à l’usage des étudiants et des équipes officinales. Thèse pour le diplôme d’État de docteur en pharmacie. Université de Nantes, faculté de pharmacie, pp 11–2Google Scholar
  7. 7.
    Cingi C, Songu M, Ural A, et al (2011) Effect of chlorhexidine gluconate and benzydamine hydrochloride mouth spray on clinical signs and quality of life of patients with streptococcal tonsillopharyngitis: multicentre, prospective, randomised, doubleblinded, placebo-controlled study. J Laryngol Otol 125:620–5CrossRefPubMedGoogle Scholar
  8. 8.
    Cingi C, Songu M, Ural A, et al (2010) Effects of chlorhexidine/benzydamine mouth spray on pain and quality of life in acute viral pharyngitis: a prospective, randomized, double-blind, placebocontrolled, multicenter study. Ear Nose Throat J 89:546–9PubMedGoogle Scholar
  9. 9.
    Bruneton J (2016) Sauges, Salvia spp. In: Pharmacognosie, phytochimie, plantes médicinales, 5e édition. Lavoisier, Paris, pp 801–6Google Scholar
  10. 10.
    Ciuman RR (2012) Phytotherapeutic and naturopathic adjuvant therapies in otorhinolaryngology. Eur Arch Otorhinolaryngol 269:389–97CrossRefPubMedGoogle Scholar
  11. 11.
    European Medicines Agency (2009) Community herbal monograph on Salvia officinalis L., Folium. http://www.ema.europa. eu/docs/en_GB/document_library/Herbal_-_Community_herbal_ monograph/2010/02/WC500070852.pdfGoogle Scholar
  12. 12.
    Schapowal A, Berger D, Klein P, et al (2009) Echinacea/sage or chlorhexidine/lidocaine for treating acute sore throats: a randomized double-blind trial. Eur J Med Res 14:406–12CrossRefPubMedPubMedCentralGoogle Scholar
  13. 13.
    European Medicines Agency (2007) Community herbal monograph on Sambucus nigra L., Flos. http://www.ema.europa.eu/ docs/en_GB/document_library/Herbal_-_Community_herbal_ monograph/2009/12/WC500018227.pdfGoogle Scholar
  14. 14.
    Natural Standard Monograph (2012) Elderberry and elder flowers (Sambucus nigra L.) 15p. https://naturalmedicines.therapeuticresearch. com/search.aspx?q=elderberry&go.x=0&go.y=0Google Scholar
  15. 15.
    World Health Organization (2004) Flos Sambuci. In: WHO monographs on selected medicinal plants 2, pp 269–75. http:// apps.who.int/medicinedocs/pdf/s4927e/s4927e.pdfGoogle Scholar
  16. 16.
    Gardiner P (2000) Peppermint (Mentha piperita). The longwood herbal task force. In-depth monograph 22 p. http://www.longwoodherbal. org/peppermint/peppermint.pdfGoogle Scholar
  17. 17.
    European Medicines Agency (2007) Community herbal monograph on Mentha piperita L., aetheroleum. http://www.ema. europa.eu/docs/en_GB/document_library/Herbal_-_Community_ herbal_monograph/2010/01/WC500059313.pdfGoogle Scholar
  18. 18.
    McKay DL, Blumberg JB (2006) A review of the bioactivity and potential health benefits of peppermint tea (Mentha piperita L.). Phytother Res 20:619–33CrossRefPubMedGoogle Scholar
  19. 19.
    Natural Standard Monograph (2014) Peppermint. 38 p https:// naturalmedicines.therapeuticresearch.com/databases/food,-herbssupplements/ p/peppermint/professional.aspxGoogle Scholar
  20. 20.
    Wintergerst ES, Maggini S, Hornig DH (2007) Contribution of selected vitamins and trace elements to immune function. Ann Nutr Metab 51:301–23CrossRefPubMedGoogle Scholar
  21. 21.
    Whiteman SC, Bianco A, Knight RA, et al (2003) Human rhinovirus selectively modulates membranous and soluble forms of its intercellular adhesion molecule-1 (ICAM-1) receptor to promote epithelial cell infectivity. J Biol Chem 278:11954–61CrossRefPubMedGoogle Scholar
  22. 22.
    Ong CL, Gillen CM, Barnett TC, et al (2014) An antimicrobial role for zinc in innate immune defence against group A streptococcus. J Infect Dis 209:1500–8CrossRefPubMedGoogle Scholar
  23. 23.
    Natural Standard Monograph (2013) Honey. 97 p https://naturalmedicines. therapeuticresearch.com/databases/food,-herbs-supplements/ h/honey/professional.aspxGoogle Scholar
  24. 24.
    Ibrahim H, Furiga A, Najahi E, et al (2012) Antibacterial, antifungal and antileishmanial activities of indolone-N-oxide derivatives. J Antibiot 65:499–504CrossRefPubMedGoogle Scholar
  25. 25.
    Qnais EY, Abu-Dieyeh M, Abdulla FA, et al (2010) The antinociceptive and anti-inflammatory effects of Salvia officinalis leaf aqueous and butanol extracts. Pharm Biol 48:1149–56CrossRefPubMedGoogle Scholar
  26. 26.
    Rodrigues MR, Kanazawa LK, das Neves TL, et al (2012) Antinociceptive and anti-inflammatory potential of extract and isolated compounds from the leaves of Salvia officinalis in mice. J Ethnopharmacol 139:519–26CrossRefPubMedGoogle Scholar
  27. 27.
    Hubbert M, Sievers H, Lehnfeld R, et al (2006) Efficacy and tolerability of a spray with Salvia officinalis in the treatment of acute pharyngitis — a randomised, double-blind, placebocontrolled study with adaptive design and interim analysis. Eur J Med Res 11:20–6PubMedGoogle Scholar
  28. 28.
    Maggini S, Wintergerst ES, Beveridge S, et al (2007) Selected vitamins and trace elements support immune function by strengthening epithelial barriers and cellular and humoral immune responses. Br J Nutr 98:S29–S35CrossRefPubMedGoogle Scholar
  29. 29.
    Prasad AS (2009) Zinc: role in immunity, oxidative stress and chronic inflammation. Curr Opin Clin Nutr Metab Care 12:646–52CrossRefPubMedGoogle Scholar
  30. 30.
    Korant BD, Butterworth BE (1976) Inhibition by zinc of rhinovirus protein cleavage: interaction of zinc with capsid polypeptides. J Virol 18:298–306PubMedPubMedCentralGoogle Scholar
  31. 31.
    Eby GA III (2009) Zinc lozenges as cure for the common cold — a review and hypothesis. Med Hypotheses 74:482–92CrossRefPubMedGoogle Scholar
  32. 32.
    Inouye S, Yamaguchi H, Takizawa T (2001) Screening of the antibacterial effects of a variety of essential oils on respiratory tract pathogens, using a modified dilution assay method. J Infect Chemother 7:251–4CrossRefPubMedGoogle Scholar
  33. 33.
    Moore N, Le Parc JM, van Ganse E, et al (2002) Tolerability of ibuprofen, aspirin and paracetamol for the treatment of cold and flu symptoms and sore throat pain. Int J Clin Pract 56:732–4PubMedGoogle Scholar
  34. 34.
    Hamre HJ, Fischer M, Heger M, et al (2005) Anthroposophic vs. conventional therapy of acute respiratory and ear infections: a prospective outcomes study. Wien Klin Wochenschr 117:256–68CrossRefPubMedGoogle Scholar

Copyright information

© Lavoisier 2017

Authors and Affiliations

  • B. Deyra
    • 1
  • I. Guinobert
    • 1
  • C. Feuillolay
    • 2
  • L. Haddioui
    • 2
  • C. Roques
    • 2
    • 3
  • A. Brochot
    • 1
  1. 1.PiLeJe laboratoireParis cedex 15France
  2. 2.FonderepharToulouse cedex 09France
  3. 3.Laboratoire de génie chimique UMR 5503, faculté des sciences pharmaceutiquesuniversité Paul-SabatierToulouseFrance

Personalised recommendations