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Phytothérapie

, Volume 14, Issue 1, pp 23–28 | Cite as

Étude clinique d’une SuperOxide Dismutase de melon naturelle et bioactive (SOD B Dimpless®) sur la cellulite

  • B. Lemaire
  • S. Le Quéré
  • G. Simoneau
  • D. Lacan
Pharmacognosie

Résumé

Une étude clinique, randomisée en double aveugle contre placebo, a été conduite sur 41 femmes ayant de la cellulite, âgées de 31 à 50 ans. 21 d’entre elles ont été supplémentées oralement avec SOD B Dimpless®, un jus de melon séché hautement concentré en SuperOxyde Dismutase (SOD), à 40 mg par jour (480 IU SOD) pendant 56 jours consécutifs. La cellulite a été mesurée par l’évaluation visuelle des capitons graisseux sur le ventre et les cuisses, à l’aide d’une échelle linéaire. La supplémentation orale avec SOD B Dimpless® a significativement réduit la cellulite sur les cuisses en comparaison avec le groupe placebo après 28 jours. Cette réduction est amplifiée après 56 jours de supplémentation. Le mécanisme d’action pourrait impliquer l’induction de l’expression des enzymes antioxydantes endogènes, conduisant à l’inhibition de la fibrose et à la stimulation de la lipolyse. D’autres investigations sont nécessaires afin de confirmer le mode d’action de SOD B Dimpless® contre la cellulite.

Mots clés

Stress oxydant Enzymes antioxydantes Fibrose Lipolyse 

Clinical trial of a natural and bioactive melon SuperOxide Dismutase (SOD B Dimpless®) on cellulite

Abstract

A randomized, double blind, placebo controlled clinical study was conducted on 41 women with cellulite aged between 31 and 50 years old. 21 of these were orally supplemented with SOD B Dimpless®, a natural dry melon juice highly concentrated in SuperOxide Dismutase (SOD) at 40 mg per day (480 IU SOD), during 56 consecutive days. Cellulite was measured visually by scoring fat nodes on stomach and thighs, according to a linear scale. The oral supplementation with SOD B Dimpless® significantly reduced cellulite on thighs compared to the placebo after 28 days. This reduction is amplified after 56 days of supplementation. The mechanism of action may involve the induction of endogenous antioxidant enzymes expression, leading to the inhibition of fibrosis and the stimulation of lipolysis. Further investigations are necessary to document the way of action of SOD B Dimpless® against cellulite.

Keywords

Oxidative stress Antioxidant enzymes Fibrosis Lipolysis 

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Copyright information

© Springer-Verlag France 2015

Authors and Affiliations

  • B. Lemaire
    • 1
  • S. Le Quéré
    • 1
  • G. Simoneau
    • 2
  • D. Lacan
    • 1
  1. 1.Bionov SARLMontpellierFrance
  2. 2.Hôpital LariboisièreUnité de Recherche ThérapeutiqueParisFrance

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