Phytothérapie

, Volume 14, Issue 1, pp 29–34 | Cite as

Positive effects of an oral supplementation by Glisodin, a gliadin-combined SOD-rich melon extract, in an animal model of dietary-induced oxidative stress

  • I. Hininger-Favier
  • M. Osman
  • A. M. Roussel
  • L. Intes
  • B. Montanari
Phytothérapie Expérimentale

Abstract

We investigated the potential protective effects of two antioxidant molecules: Glisodin, a gliadin combined copper-zinc superoxide dismutase SOD (Cu,Zn SOD)-rich melon extract, SOD is a known enzyme that has been best studied as a regulator of antioxidant defence, and an antioxidant agent N-acetylcysteine (NAC). Glisodin, given orally to rats fed a chow diet, as 180 U/d during 2 weeks in a preconditioning treatment, and then for 8 weeks, combined to a high fat/high fructose diet (HF/HFr), had more positive effects than NAC (100 mg/d), not only on oxidative stress parameters, but also on features of the metabolic-syndrome. DNA oxidative damages, lipid peroxidation, and fasting glycaemia were lower in rats receiving Glisodin than in those supplemented by NAC. In addition, insulin sensitivity was improved and mesenteric fat was significantly lower in rats fed the Fr/Fe diet plus Glisodin than in animals fed NAC supplementation.

These data suggest potential beneficial effects of oral Glisodin supplementation in preventing metabolic alterations related to the metabolic syndrome.

Keywords

Glisodin SOD melon extract Oxidative stress Metabolic syndrome 

Effets bénéfiques d’une supplémentation orale par le Glisodin, un extrait de melon combiné à de la gliadine, dans un modèle animal de stress oxydant induit par l’alimentation

Résumé

Nous avons comparé les effets de deux molécules antioxydantes, le Glisodin, un extrait de melon riche en superoxide dismutase Cu, Zn (Cu, Zn-SOD) combiné à de la gliadine, et un agent antioxydant la NAC, N acétyl cystéine. Les deux antioxydants ont été administrés oralement 2 semaines en pré-conditionnement à des rats nourris au régime d’entretien, puis 8 semaines associées à un régime riche en fer et en fructose induisant un stress oxydant. Le Glisodin (180 U/j) a des effets bénéfiques supérieurs à ceux de la NAC (100 mg/j) non seulement sur le stress oxydant (dommages oxydatifs aux ADN, peroxydation lipidique) mais aussi sur les paramètres du syndrome métabolique (glycémie a jeun, insulinémie, graisse mésentérique).

Ces résultats suggèrent une utilisation thérapeutique du Glisodin dans le syndrome métabolique.

Mots clés

Glisodin SOD de melon Stress oxydant Syndrome métabolique 

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Copyright information

© Springer-Verlag France 2015

Authors and Affiliations

  • I. Hininger-Favier
    • 1
  • M. Osman
    • 1
  • A. M. Roussel
    • 1
  • L. Intes
    • 2
  • B. Montanari
    • 2
  1. 1.LBFA/Inserm 1055Joseph Fourier UniversityGrenobleFrance
  2. 2.ISOCELL NUTRAParisFrance

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