Advertisement

Phytothérapie

, Volume 10, Issue 5, pp 293–297 | Cite as

Toxicité aiguë et activité analgésique de l'extrait méthanolique de Rumex nervosus Vahl

  • A. Alwashli
  • M. Al Sobarry
  • Y. Cherrah
  • K. AlaouiEmail author
Article Original Toxicologie

Résumé

Rumex nervosus Vahl est une plante utilisée traditionnellement au Yémen comme anti-inflammatoire et en traitement de la douleur. Notre étude se propose d'évaluer la toxicité aiguë et le pouvoir analgésique et central de l'extrait méthanolique de ses feuilles.

La DL50 a été évaluée à 1028 mg/kg VO, avec des limites de confiance à 95 % (723,6<DL50<1416). L'extrait révèle un effet analgésique périphérique par le test de Koster avec un pouvoir de protection notoire vis-à-vis de crampes abdominales, estimé à 32 % à 50 mg/kg VO et à 43 % à 100 mg/kg VO. Par ailleurs, un faible analgésique central morphine-like est enregistré par le test de Tail Flick à 100mg/kgVO.

Mots-clés

Rumex nervosus Vahl Extrait méthanolique Toxicité aiguë Activité analgésique 

Acute toxicity and analgesic activity of the methanolic extract of Rumex nervosus Vahl

Abstract

Rumex nervosus Vahl has been used traditionally for treatment of inflammatory and painful condition in Yemen. We performed the central and peripheral analgesic activity by using both pharmacological tests, Koster and tail flick.

The DL50 value is 1028 mg/kg (per os) with limits of confidence at 95% (723.6<DL50<1416).

The methanolic extract of Rumex nervosus Vahl produced an important peripheral analgesic effect, with a power of protection against the abdominal cramp, about 32% at 50 mg/kg and 43% at 100 mg/kg, via oral pathway. Moreover, a low central analgesic activity morphine like appears to 100 mg/kg.

Keywords

Rumex nervosus Vahl Methanolic extract Acute toxicity Analgesic activity 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Références

  1. 1.
    Al-Dubai AS, Al-khulaidi AA (1996) Medical and aromatic plants of Yemen. Obadi Center for Studies and Publishing, Sanaa, YemenGoogle Scholar
  2. 2.
    Al-Meshal IA, Mossa JS, Al-Yahya MA, et al (1982) Phytochemical and biological screening of Saudi medicinal plants. Fitoterapia 53(1–2):79Google Scholar
  3. 3.
    Bently GA, Newtown SH, Starr J (1983) Studies on the anti-nociceptive action of α-agonist drug and their interaction with opioid mechanisms. Br J Pharmacol 73:125–134CrossRefGoogle Scholar
  4. 4.
    Bittar M, De Sousa MM, Yunes R, et al (2000) Anti-nociceptive activity of I3, II8-binaringenin, a biflavonoid present in plants of the Guttiferae. Planta Medica 66:84–86PubMedCrossRefGoogle Scholar
  5. 5.
    Brune K, Lang R (1964) Mode of action of peripheral analgesics. Arzeim Forsh Drags Res 134(11):29Google Scholar
  6. 6.
    Delporte C, Backhouse N, Inostroza V, et al (2007) Analgesic activity of Ugni molinae (murtilla) in mice models of acute pain. Jl Ethno Pharmacol 12:162–165Google Scholar
  7. 7.
    Collier HJ, Dinneen LC (1968) The abdominal constriction response and its suppression by analgesic drugs in the mouse. Br J Pharmacol 32:295–310Google Scholar
  8. 8.
    Desta B (1993) Ethiopian traditional herbal drugs. Part 11:Antimicrobial activity of medicinal plants. Ethnopharmalogy 39(2):129CrossRefGoogle Scholar
  9. 9.
    Directives du JOCE. Directive 91/507/CCE du 19 juillet 1991. JOCE du 26 août 1991Google Scholar
  10. 10.
    Dongmo AB, Nguelefack TB, Lacaille-Dubois MA (2005) Anti-nociceptive anti-inflammatory activities of acacia pennata wild (Mimmo Saceae). J Ethno Pharmacol 98:201–206Google Scholar
  11. 11.
    Duarte JDG, Nakamura M, Ferreira SH (1988) Participation of the sympathetic system in acetic acid induced writhing in mice. Braz J Med Biol Res 21:34Google Scholar
  12. 12.
    Nguemfo EL, Dimo T, Azebaze AGB, et al (2007) Anti-inflammatory and anti-nociceptive activities of the stem bark extracts from Allonblakia monticola STANER L.C.(Guttiferae). Jl Ethno Pharmacol 114:417–424Google Scholar
  13. 13.
    Evan Prince S, Chandel S, Mahaboob KR (2009) Evaluation of analgesic, anti-pyretic and ulcerogenic effect of Withaferin A. IJIB 6(2):52Google Scholar
  14. 14.
    Fleurentin J, Pelt JM (1982) Repertory of drugs and medicinal of Yemen. J Ethnopharmacol 6(1):85PubMedCrossRefGoogle Scholar
  15. 15.
    Mariam TG, Murthy PN, Ranganathan P, et al (1993) Antimicrobial screening of Rumex abyssinicus and Rumex nervosus. Eastern Pharm 36(33):131–133Google Scholar
  16. 16.
    Bouidida EH, Alaoui K, Cherrah Y, et al (2005) Toxicité aiguë et action analgésique des huiles essentielles de Nepeta atlantica Google Scholar
  17. 17.
    Hasard R, Cheymol J (1970) Analgésiques centraux. Manuel de Pharmacologie 2e édition, Masson et cie 124-46Google Scholar
  18. 18.
    Koo HJ, Lim KH, Jung HJ, Park EH (2006) Anti-inflammatory evaluation of Gardenia extrat, geniposid and genipin. J Ethnopharmacol 103:496–500PubMedCrossRefGoogle Scholar
  19. 19.
    Koster R, Anderson M, Debeer EJ (1959) Acetic acid for analgesic screening. Fed proc 18:412Google Scholar
  20. 20.
    Levin JD, Lau W, Kwait G, Gotetzel EJ (1984) Leukotriene B produces hyperalgesia that is dependent on the polymorphonuclear leucocytes. Sciences 225:743–745CrossRefGoogle Scholar
  21. 21.
    Litchfield JT, Wilcoxon F (1949) A Simplified method of evaluating a dose effect experiments. JPET 96–99Google Scholar
  22. 22.
    Middleton E, Kandaswami CK, Theoharides T (2000) The effects of plant flavonoids on mammalian cells imlicatins for inflammation, heart disease and cancer. Pharmacol Rev 52:673–751PubMedGoogle Scholar
  23. 23.
    Rubilar M, Pinelo M, Lhl M, et al (2006) Murta leaves (Ugni molinae Turcz) as a source of antioxidant polyphenols. J Agric Food Chem 54:59–64PubMedCrossRefGoogle Scholar
  24. 24.
    Sawynok J (2003) Topical and peripherally acting analgesics. Pharmacol Rev 55:1–20PubMedCrossRefGoogle Scholar
  25. 25.
    Wall ME, Taylor H, Ambrisiol D (1969) Plant anti tumor agent. 3. A convenient separation of tannins from other plant constituents. Pharm Sci 58(7):839CrossRefGoogle Scholar
  26. 26.
    Yam MF, Asmawi MZ, Basir R (2008) An investigation of the anti-inflammatory and analgesic effects of Orthosiphon stamineus leaf extract. J Med Food 11:362–368PubMedCrossRefGoogle Scholar
  27. 27.
    Zakaria ZA, Abdul Gani ZDF (2008) Anti-nociceptive,antiinflamatory, anti-pyretic properties of an aqueous extract of Dicranoptevis Linearis leaves in experimental animal models. J Nat Med 62(4):179–187PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag France 2012

Authors and Affiliations

  • A. Alwashli
    • 1
  • M. Al Sobarry
    • 1
  • Y. Cherrah
    • 1
  • K. Alaoui
    • 1
    Email author
  1. 1.Equipe de Recherche de Toxico-Pharmacodynamie ERTP accréditée 07/07, Laboratoire de Pharmacologie et Toxicologie, Faculté de Médecine et de Pharmacie de RabatUniversité Mohammed V SouissiRabatMaroc

Personalised recommendations