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Searching for potent and specific antibiotics against pathogenic Helicobacter and Campylobacter strains

  • Yasushi Ogasawara
  • Tohru Dairi
Natural Products - Original Paper
  • 111 Downloads

Abstract

Menaquinone is an obligatory component of the electron-transfer pathway in microorganisms. Its biosynthetic pathway was established by pioneering studies with Escherichia coli and it was revealed to be derived from chorismate by Men enzymes. However, we identified an alternative pathway, the futalosine pathway, operating in some microorganisms including Helicobacter pylori and Campylobacter jejuni, which cause gastric carcinoma and diarrhea, respectively. Because some useful intestinal bacteria, such as lactobacilli, use the canonical pathway, the futalosine pathway is an attractive target for development of chemotherapeutics for the abovementioned pathogens. In this mini-review, we summarize compounds that inhibit Mqn enzymes involved in the futalosine pathway discovered to date.

Keywords

Menaquinone Biosynthesis Futalosine pathway Inhibitors 

Notes

Acknowledgements

This work was supported by Grants-in-Aid for Scientific Research on Innovative Areas from MEXT, Japan (JSPS KAKENHI Grant number 16H06452) and Grants-in-Aid for Scientific Research from JSPS (18H03937) to T.D. We thank Robbie Lewis, MSc, from Edanz Group (http://www.edanzediting.com/ac) for editing a draft of this manuscript.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Society for Industrial Microbiology and Biotechnology 2018

Authors and Affiliations

  1. 1.Graduate School of EngineeringHokkaido UniversitySapporoJapan

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