Bioactive molecules from Nocardia: diversity, bioactivities and biosynthesis

  • Dipesh Dhakal
  • Vijay Rayamajhi
  • Ravindra Mishra
  • Jae Kyung SohngEmail author
Metabolic Engineering and Synthetic Biology - Original Paper


Nocardia spp. are catalase positive, aerobic, and non-motile Gram-positive filamentous bacteria. Many Nocarida spp. have been reported as unusual causes of diverse clinical diseases in both humans and animals. Therefore, they have been studied for a long time, primarily focusing on strain characterization, taxonomic classification of new isolates, and host pathophysiology. Currently, there are emerging interests in isolating bioactive molecules from diverse actinobacteria including Nocardia spp. and studying their biosynthetic mechanisms. In addition, these species possess significant metabolic capacity, which has been utilized for generating diverse functionalized bioactive molecules by whole cell biotransformation. This review summarizes the structural diversity and biological activities of compounds biosynthesized or biotransformed by Nocardia spp. Furthermore, the recent advances on biosynthetic mechanisms and genetic engineering approaches for enhanced production or structural/functional modification are presented.


Nocardia spp. Bioactive compounds Biosynthetic mechanism Structural modifications Biotransformation 



This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST) (NRF-2014R1A2A2A01002875, JKS) and (NRF-2017R1D1A1B03036273, DD). The authors want to dedicate this manuscript in honor of Professors Heinz Floss and Chris Walsh for inspiring research in the field of natural products.

Supplementary material

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Supplementary material 1 (DOCX 317 kb)


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© Society for Industrial Microbiology and Biotechnology 2019

Authors and Affiliations

  1. 1.Department of Life Science and Biochemical EngineeringSunMoon UniversityAsan-siRepublic of Korea
  2. 2.Department of BT-Convergent Pharmaceutical EngineeringSunMoon UniversityAsan-siRepublic of Korea

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