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Exploitation of the Streptomyces coelicolor A3(2) genome sequence for discovery of new natural products and biosynthetic pathways

  • Gregory L. Challis
Review

Abstract

Streptomyces, and related genera of Actinobacteria, are renowned for their ability to produce antibiotics and other bioactive natural products with a wide range of applications in medicine and agriculture. Streptomyces coelicolor A3(2) is a model organism that has been used for more than five decades to study the genetic and biochemical basis for the production of bioactive metabolites. In 2002, the complete genome sequence of S. coelicolor was published. This greatly accelerated progress in understanding the biosynthesis of metabolites known or suspected to be produced by S. coelicolor and revealed that streptomycetes have far greater potential to produce bioactive natural products than suggested by classical bioassay-guided isolation studies. In this article, efforts to exploit the S. coelicolor genome sequence for the discovery of novel natural products and biosynthetic pathways are summarized.

Keywords

Antibiotic Siderophore Polyketide synthase Nonribosomal peptide synthetase Terpene synthase 

Notes

Acknowledgments

Funding from the BBSRC (EGH16081, B16610, BBSSK200310147, BB/S/B14450 and BB/E008003/1), the European Commission (Contract Nos. LSHM-CT-2004-005224 and MEIF-CT-2003-501686), the NIH (1R01GM77147-01A1), the Wellcome Trust, the EPSRC, the Royal Society and the Royal Society of Chemistry for S. coelicolor specialized metabolism research in the author’s laboratory is gratefully acknowledged. I am indebted to the many talented coworkers and collaborators, whose names appear in the reference section, for their contributions to research on S. coelicolor specialized metabolism. This article is dedicated to Prof. Sir David Hopwood on the occasion of his 80th birthday.

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© Society for Industrial Microbiology and Biotechnology 2013

Authors and Affiliations

  1. 1.Department of ChemistryUniversity of WarwickCoventryUK

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