Engineering microbial factories for synthesis of value-added products

Review

Abstract

Microorganisms have become an increasingly important platform for the production of drugs, chemicals, and biofuels from renewable resources. Advances in protein engineering, metabolic engineering, and synthetic biology enable redesigning microbial cellular networks and fine-tuning physiological capabilities, thus generating industrially viable strains for the production of natural and unnatural value-added compounds. In this review, we describe the recent progress on engineering microbial factories for synthesis of valued-added products including alkaloids, terpenoids, flavonoids, polyketides, non-ribosomal peptides, biofuels, and chemicals. Related topics on lignocellulose degradation, sugar utilization, and microbial tolerance improvement will also be discussed.

Keywords

Synthetic biology Metabolic engineering Microbial synthesis Value-added products Natural products Fuels and chemicals 

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Copyright information

© Society for Industrial Microbiology 2011

Authors and Affiliations

  1. 1.Department of Chemical and Biomolecular EngineeringUniversity of Illinois at Urbana-ChampaignUrbanaUSA
  2. 2.Departments of Chemistry and Biochemistry, Institute of Genomic BiologyUniversity of Illinois at Urbana-ChampaignUrbanaUSA

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