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Different roads to discovery; Prontosil (hence sulfa drugs) and penicillin (hence β-lactams)

  • Ronald Bentley
Review

Abstract

The important chemotherapeutic agents, Prontosil and pentenylpenicillin (penicillin F), were investigated initially by two men, Domagk and Fleming, who had been influenced by the horrendous wound infections of World War I. The very different pathways leading to their development and to that of the successor antibacterials (sulfa drugs, further penicillins, semi-synthetic penicillins), including the role played by patents, are discussed.

Keywords

Prontosil Penicillins Sulfanilamide Sulfa drugs Semi-synthetic penicillins Submerged fermentation Patents Domagk Fleming Florey Chain 

Notes

Acknowledgments

I thank Philip Eagle of the British Library for information on British and European patents, Ruediger Borstel of Bayer Corporate History and Archives, and Thomas Hager for correspondence concerning Prontosil. Thanks are also due to A. Demain for helpful comments after reading a draft of this paper. A reviewer is thanked for useful suggestions.

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Copyright information

© Society for Industrial Microbiology 2009

Authors and Affiliations

  1. 1.Department of Biological SciencesUniversity of PittsburghPittsburghUSA
  2. 2.PittsburghUSA

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