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Complexity analysis of heart rate variability in chronic obstructive pulmonary disease: relationship with severity and symptoms

  • Nelson Francisco SerrãoJr.
  • Alberto Porta
  • Vinicius Minatel
  • Antônio A. M. Castro
  • Aparecida Maria Catai
  • Luciana Maria Malosá Sampaio
  • Ross Arena
  • Audrey Borghi-SilvaEmail author
Research Article

Abstract

Purpose

Chronic obstructive pulmonary disease (COPD) negatively impacts autonomic control of the heart rate, as assessed by time and frequency domains of heart rate variability (HRV) analysis. However, it is unknown whether symbolic dynamic analysis may identify cardiac autonomic impairment, and whether such nonlinear indices may be associated with disease severity, prognostic markers, perceived dyspnea and functional capacity in patients with COPD. The current study assessed cardiac autonomic modulation by symbolic analysis of HRV in patients with COPD compared with healthy controls.

Methods

We recruited 54 COPD patients and 20 healthy controls. The interval between two successive R-wave peaks was calculated in the resting supine position. HRV was analyzed using symbolic markers and Shannon entropy (SE). The six-minute walk test (6MWT) was applied in a 30-m corridor.

Results

We found a lower 6MWT distance in patients with COPD compared with healthy controls (p < 0.05). We found increased SE and decreased percentage of no variation patterns (0V%) in COPD patients compared with the control group (p = 0.001). Significant correlations were found between the percentage of one variation pattern (1V%) and the Medical Research Council dyspnea scale (r = 0.38, p = 0.01), BODE index (r = 0.38, p = 0.01), forced expiratory volume in the first second (FEV1) [L] (r = −0.44, p = 0.003) and FEV1 [%] (r = −0.35, p = 0.02). It was found that SE was inversely associated with 0V% (r = −0.87, p < 0.0001).

Conclusion

COPD patients present with depressed sympathetic modulation of HR and higher SE compared with healthy controls. This increased irregularity was inversely associated with 0V%. These results suggested that COPD patients seem to have a cardiac control shifted towards a parasympathetic predominance compared with controls. Symbolic dynamic and complexity index of HRV are related to disease severity, symptoms and functional impairment in these patients.

Keywords

Respiratory disease Symbolic analysis Conditional entropy Functional capacity 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2020

Authors and Affiliations

  • Nelson Francisco SerrãoJr.
    • 1
  • Alberto Porta
    • 2
    • 3
  • Vinicius Minatel
    • 4
  • Antônio A. M. Castro
    • 1
  • Aparecida Maria Catai
    • 5
  • Luciana Maria Malosá Sampaio
    • 6
  • Ross Arena
    • 7
  • Audrey Borghi-Silva
    • 8
    Email author
  1. 1.Physical Therapy DepartmentFederal University of PampaUruguaianaBrazil
  2. 2.Department of Biomedical Sciences for HealthUniversity of MilanMilanItaly
  3. 3.Department of CardiothoracicVascular Anesthesia and Intensive Care, IRCCS Policlinico San DonatoSan Donato Milanese, MilanItaly
  4. 4.Physical Therapy DepartmentUniversity Center TiradentesMaceióBrazil
  5. 5.Cardiovascular Physical Therapy Laboratory, Department of Physical TherapyFederal University of São CarlosSao PauloBrazil
  6. 6.Sleep LaboratoryNove de Julho University (UNINOVE)Sao PauloBrazil
  7. 7.Department of Physical Therapy, College of Applied Health SciencesUniversity of Illinois at ChicagoChicagoUSA
  8. 8.Cardiopulmonary Physical Therapy Laboratory (LACAP), Department of Physical TherapyFederal University of São Carlos (UFSCar)São CarlosBrazil

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